Results 181 to 190 of about 61,821 (357)

PF155 COMBINATION OF FLOTETUZUMAB, A CD123 X CD3 BISPECIFIC DART^® MOLECULE, AND BLINATUMOMAB, A CD19 X CD3 BITE MOLECULE, TO PREVENT ANTIGEN ESCAPE IN B‐CELL PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA

, 2019
D. Slavkovic Lukic, Johannes Duell, Jan Davidson‐Moncada, A. Schlagowsky, Hermann Einsele, Monika Szczepanowski, Denis M. Schewe, M. Brüggemann, Max S. Topp   +8 more
openalex   +1 more source

Docetaxel‐Induced Immune Activation Shows Antitumor Synergy With the Tumor‐Targeted CD40 Agonist KK2269

Cancer Science, EarlyView.
CD40 agonists have demonstrated proof‐of‐concept for converting an immunologically cold tumor into a hot tumor in preclinical studies; however, clinically, they have shown limited antitumor efficacy as monotherapy. We tested a tumor‐targeted CD40 agonist, KK2269 (a bispecific antibody that binds to CD40 and EpCAM), in combination with various ...
Yuta Tezuka, Kyoko Kawasaki, Yoshiki Sumitomo, Masato Saito, Akari Yao, Munetoshi Ando   +5 more
wiley   +1 more source

Bispecific FpFs: a versatile tool for preclinical antibody development

Matthew Collins, Nkiruka Ibeanu, Wiktoria Roksana Grabowska, Sahar Awwad, Peng T. Khaw, Steve Brocchini, Hanieh Khalili   +6 more
openalex   +2 more sources

Data from ⁸⁹Zr-labeled Bispecific T-cell Engager AMG 211 PET Shows AMG 211 Accumulation in CD3-rich Tissues and Clear, Heterogeneous Tumor Uptake

, 2023
Kirsten L. Moek, Stijn J.H. Waaijer, Iris C. Kok, Frans V. Suurs, Adrienne H. Brouwers, C. Willemien Menke‐van der Houven van Oordt, Thijs T. Wind, Jourik A. Gietema, Carolien P. Schröder, Shekar V.K. Mahesh, Annelies Jorritsma‐Smit, Marjolijn N. Lub–de Hooge, Rudolf S.N. Fehrmann, Derk Jan A. de Groot, Elisabeth G.E. de Vries   +14 more
openalex   +1 more source

Orthotopic Esophageal Cancer Xenograft Model in Immunosuppressed Microminipigs for Near‐Infrared Fluorescence Endoscopy

Cancer Science, EarlyView.
We report the first successful orthotopic engraftment of human esophageal squamous cell carcinoma in immunosuppressed microminipigs and demonstrate high‐contrast near‐infrared fluorescence endoscopic detection using EGFR‐targeted cetuximab. This large‐animal model bridges preclinical imaging research and future clinical translation in esophageal cancer.
Takanori Miyake, Yutaka Kawano, Takanori Kashihara, Masaki Takasu, Kentaroh Takagaki, Shota Fujimoto, Tomoyuki Kawaguchi, Kaizo Kagemoto, Yoshifumi Kida, Koichi Okamoto, Masahiro Sogabe, Naoki Muguruma, Koichi Tsuneyama, Yasushi Sato, Tetsuji Takayama   +14 more
wiley   +1 more source

Targeting T-Cells for Cancer Treatment: Current Clinical Strategies and Challenges. [PDF]

Biomedicines
Rotte A, Sopjani M, Bhandaru M.
europepmc   +1 more source

Pancreatic Cancer—Advances in the Last 50 Years

World Journal of Surgery, EarlyView.
S. George Barreto, Anirban Maitra, Eileen M. O'Reilly, Dushyant Sahani, Richard Zheng, Charles J. Yeo   +5 more
wiley   +1 more source

Bispecific Ligand‐Based EphB4 CAR‐T Cells Generated Using Ephrin‐B2 Show Potent Antitumor Activity Against Lung Adenocarcinoma

Cancer Science, EarlyView.
EphB4 and EphA2 positivity in lung adenocarcinoma samples was high. Ligand‐based EphB4 CAR‐T cells exhibit bispecificity, targeting both EphB4 and EphA2. EphB4 CAR‐T cells exert significant antitumor effects against lung adenocarcinoma. ABSTRACT Chimeric antigen receptor (CAR)‐T cells generated using ephrin‐B2, the natural ligand for ephrin type‐B ...
Hirotaka Kumeda, Koichi Hirabayashi, Shuji Mishima, Kotaro Morita, Yu Furui, Marina Fujioka, Tomoyuki Nakajima, Miyuki Tanaka, Yoshinori Sato, Takeshi Uehara, Shigeki Yagyu, Kimihiro Shimizu, Yozo Nakazawa   +12 more
wiley   +1 more source

Recurrent cytokine release syndrome in patients receiving bispecific antibody therapy for multiple myeloma: a case series. [PDF]

Ann Hematol
Della Pepa R, Leone A, Grimaldi F, Avilia S, Memoli M, Rossini B, Liberatore C, Pane F.   +7 more
europepmc   +1 more source

Video S2B from Harnessing the hERG1/β1 Integrin Complex via a Novel Bispecific Single-chain Antibody: An Effective Strategy against Solid Cancers

, 2023
Claudia Duranti, Jessica Iorio, Tiziano Lottini, Elena Lastraioli, Silvia Crescioli, Giacomo Bagni, Matteo Lulli, Chiara Capitani, Rayhana Bouazzi, Matteo Stefanini, Laura Carraresi, Luisa Iamele, Hugo de Jonge, Annarosa Arcangeli   +13 more
openalex   +1 more source