Results 261 to 270 of about 61,821 (357)
European Journal of Haematology, Volume 116, Issue 6, Page 771-784, June 2026.ABSTRACT Primary refractory Diffuse Large B‐Cell Lymphoma is associated with poor outcomes and limited responsiveness to conventional salvage therapies. Although CAR T‐cell therapy represents the standard of care in this setting, a substantial proportion of patients cannot receive it despite meeting disease‐related criteria. In this review, “unsuitable”
Santino Caserta +12 more
wiley +1 more source
A Generalized Minimal PBPK-PD Model of Bispecific Antibodies: Case Studies and Applications in Drug Development. [PDF]
CPT Pharmacometrics Syst PharmacolSpinosa P +4 more
europepmc +1 more source
Manufacturing and clinical applications of non‐CAR‐T immune effector cells
Transfusion, EarlyView.
Thane Kubik +2 more
wiley +1 more source
European Journal of Haematology, Volume 116, Issue 6, Page 928-936, June 2026.ABSTRACT Modern therapies have clearly marked the history of multiple myeloma (MM), leading to undisputed advantages in terms of sustained responses and prolonged survival, while progressively improving patients' quality of life. Nonetheless, disease recurrence and resistance to available therapies underscore the importance of identifying additional ...
K. Mancuso +18 more
wiley +1 more source
Flat dose intravenous immunoglobulin primary infection prophylaxis in multiple myeloma patients on BCMA and GPRC5D bispecific antibody therapy: the Vanderbilt experience. [PDF]
Front ImmunolMarneni N +14 more
europepmc +1 more source
FEBS Open Bio, Volume 16, Issue 5, Page 1030-1043, May 2026.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source
Dendritic Cell-T Cell Crosstalk Mediated Cancer Immunotherapy. [PDF]
Exploration (Beijing)Cai Y, Chen J, Li Y.
europepmc +1 more source
Sensing and Reprogramming Surface Receptor Activation With Synthetic Transcriptional Circuits
Advanced Science, Volume 13, Issue 25, 4 May 2026.A synthetic receptor‐signalling induced transcription (RESIT) circuit is designed based on receptor activation mediated split protease complementation and release of membrane‐tethered synthetic transcriptional modules. The RESIT system enables probing Ca2+ entry, receptor tyrosine kinase (RTK) activities and Ras activation, and reprogramming RTK ...
Fei Liu +5 more
wiley +1 more source
Editorial: Bispecific antibodies and their conjugates in solid tumors and hematological malignancies. [PDF]
Front ImmunolPüsküllüoğlu M, Pacholczak-Madej R.
europepmc +1 more source