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Strategies for the Generation of Bispecific Antibodies
ChemBioChemBispecific antibodies (BsAbs) are engineered immunoglobulins that can simultaneously recognize two distinct antigens or two distinct epitopes on the same antigen. They exhibit cooperative therapeutic effects surpassing those of natural monoclonal antibodies, such as bridging the immune cells and tumor cells to stimulate targeted immune response, or ...
Zhengyang Yuan +4 more
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Introduction: bispecific antibodies
Journal of Immunological Methods, 2001D M, Segal, G J, Weiner, L M, Weiner
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Discovery and development of bispecific antibodies
Protein Expression and PurificationBispecific antibodies (BsAbs) represent a significant breakthrough in antibody-based therapeutics, offering the unique capability to engage two distinct targets simultaneously. BsAbs are expected to exert therapeutic effects that are unattainable with conventional antibody drugs. Specifically, they are being developed for use in intercellular bridging,
Tetsuya Wakabayashi, Taichi Kuramochi
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Broad neutralization of SARS-CoV-2 variants by an inhalable bispecific single-domain antibody
Cell, 2022Cheng Li, Wuqiang Zhan, Gaowei Hu
exaly
How to Make Bispecific Antibodies
2000This protocol describes the production of bispecific F(ab')2 antibody derivatives (BsAbs) by the linking of two Fab' fragments via their hinge region SH groups using the bifunctional crosslinker o-phenylenedimaleimide (o-PDM) as described by Glennie et al. (1,2). The procedure is illustrated in Fig. 1.
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