Results 261 to 270 of about 29,485 (291)
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Bispecific antibodies rise again
Nature Reviews Drug Discovery, 2014Amgen's blinatumomab is setting the stage for a bispecific revival, enabled by new formats that may solve the field's long-standing problems.
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How to Make Bispecific Antibodies
2000This protocol describes the production of bispecific F(ab')2 antibody derivatives (BsAbs) by the linking of two Fab' fragments via their hinge region SH groups using the bifunctional crosslinker o-phenylenedimaleimide (o-PDM) as described by Glennie et al. (1,2). The procedure is illustrated in Fig. 1.
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Bispecific Antibody Therapy in Hemophilia
New England Journal of Medicine, 2017Hemophilia A is the most common severe inherited bleeding disorder in humans. Bleeding occurs as a result of a deficiency or dysfunction of the procoagulant cofactor protein, factor VIII. For the past 50 years, the treatment and prevention of bleeding in hemophilia A has involved the intravenous infusion of plasma-derived or recombinant factor VIII ...
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Bispecific Antibodies for Cancer Therapy
Immunotherapy, 2009Bispecific antibodies, in contrast to conventional monoclonal antibodies, can bind simultaneously two different antigens. Taking advantage of this virtue, they are mostly designed for immune effector cell redirection to tumors and for radionuclide pretargeting to tumors.
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The state of the art of bispecific antibodies for treating human malignancies
EMBO Molecular Medicine, 2021Shuhang Wang, Kun Chen, Qi Lei
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Assessing the toxicity of bispecific antibodies
Nature Biomedical Engineering, 2023Marta Buzzetti, Marco Gerlinger
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Bispecific Antibodies in Lung Cancer: A State-of-the-Art Review
Pharmaceuticals, 2023Atulya A Khosla +2 more
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Bispecific Antibodies as a Development Platform for New Concepts and Treatment Strategies
International Journal of Molecular Sciences, 2017Weihong Wen, Weijun Qin, Wen Weihong
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