Bisphosphonate Associated Osteonecrosis of the Jaw [PDF]
The Journal of Rheumatology, 2009 In 2003, the first reports describing osteonecrosis of the jaw (ONJ) in patients receiving bisphosphonates (BP) were published. These cases occurred in patients with cancer receiving high-dose intravenous BP; however, 5% of the cases were in patients with osteoporosis receiving low-dose bisphosphonate therapy.
Aliya Khan +29 more
semanticscholar +7 more sources
Systemic immunity shapes the oral microbiome and susceptibility to bisphosphonate-associated osteonecrosis of the jaw. [PDF]
J Transl Med, 2015 Osteonecrosis of the jaw (ONJ) is a rare but serious adverse drug effect linked to long-term and/or high-dose exposure to nitrogen-bisphosphonates (N-BP), the standard of care for the treatment of bone fragility disorders.
Kalyan S +6 more
europepmc +4 more sources
Geranyl-geraniol addition affects potency of bisphosphonates-a comparison in vitro promising a therapeutic approach for bisphosphonate-associated osteonecrosis of the jaw and oral wound healing. [PDF]
Oral Maxillofac Surg, 2022 Purpose Analysis of the influence of geranyl-geraniol (GG) addition on four bisphosphonate derivatives regarding their influence on cell viability and migration ability of bone metabolism and endothelial cells in vitro.
Otto M +4 more
europepmc +4 more sources
Bisphosphonate Associated Osteonecrosis of the Jaw: An Update on Pathophysiology, Risk Factors, and Treatment [PDF]
International Journal of Dentistry, 2014 Osteonecrosis of the jaw in patients treated with bisphosphonates is a relatively rare but well known complication at maxillofacial units around the world. It has been speculated that the medication, especially long-term i.v.
Lars Rasmusson, Jahan Abtahi
doaj +3 more sources
Risk factors for bisphosphonate-associated osteonecrosis of the jaw in the prospective randomized trial of adjuvant bisphosphonates for early-stage breast cancer (SWOG 0307). [PDF]
Support Care Cancer, 2021 Kizub DA +10 more
europepmc +4 more sources
Pharmacogenetics of bisphosphonate-associated osteonecrosis of the jaw [PDF]
Frontiers in Bioscience, 2010 An undesirable effect associated with bisphosphonates is osteonecrosis of the jaw (ONJ). Case reports discussed ONJ development in patients with multiple myeloma or metastatic cancers receiving bisphosphonates as palliation for malignant bone disease. No causative relationship has been unequivocally demonstrated between ONJ and bisphosphonate therapy ...
Maria Luisa Brandi
semanticscholar +6 more sources
Bisphosphonate-associated osteonecrosis of the jaw: the rheumatologist's role. [PDF]
Arthritis research & therapy, 2006 Several recent reports have described osteonecrosis of the jaws (ONJ) associated with the use of bisphosphonates. Rheumatologists treating bone diseases with bisphosphonate need, therefore, to be aware of this potential risk and plan the prophylaxis, early diagnosis and prevention of potential consequences.
F. Capsoni +2 more
semanticscholar +4 more sources
Bisphosphonate-associated osteonecrosis of the jaw
Canadian family physician Medecin de famille canadien, 2008 Ira Pande
semanticscholar +5 more sources
Time since last intravenous bisphosphonate and risk of osteonecrosis of the jaw in osteoporotic patients [PDF]
Nature CommunicationsMedication-related osteonecrosis of the jaw is a rare but serious condition in which the jawbone fails to heal and becomes necrotic, typically after dental surgery in patients treated with bisphosphonates.
Jung-Hyun Park +6 more
doaj +3 more sources
Stress response in periodontal ligament stem cells may contribute to bisphosphonate‑associated osteonecrosis of the jaw: A gene expression array analysis. [PDF]
Mol Med Rep, 2020 Gene expression alterations in periodontal ligament stem cells (PDLSCs) during bisphosphonate (BP) usage and the transcriptomic mechanism underlying BP-related osteonecrosis of the jaw have not been fully elucidated.
Shi Y +6 more
europepmc +2 more sources