Bisphosphonate Associated Osteonecrosis of the Jaw: An Update on Pathophysiology, Risk Factors, and Treatment [PDF]
International Journal of Dentistry, 2014 Osteonecrosis of the jaw in patients treated with bisphosphonates is a relatively rare but well known complication at maxillofacial units around the world. It has been speculated that the medication, especially long-term i.v.
Lars Rasmusson, Jahan Abtahi
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Bisphosphonate-associated osteonecrosis of the jaw
Indian Journal of Rheumatology, 2008 I Pande
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Pharmacogenetics of bisphosphonate-associated osteonecrosis of the jaw [PDF]
Frontiers in Bioscience, 2011 An undesirable effect associated with bisphosphonates is osteonecrosis of the jaw (ONJ). Case reports discussed ONJ development in patients with multiple myeloma or metastatic cancers receiving bisphosphonates as palliation for malignant bone disease. No causative relationship has been unequivocally demonstrated between ONJ and bisphosphonate therapy ...
MARINI, FRANCESCA +6 more
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Bisphosphonate Related Osteonecrosis of the Jaw: A Study of 18 Cases Associated with Fungal Infection [PDF]
International Journal of Dentistry, 2014 Osteonecrosis of the jaw (ONJ) is a serious complication associated with oral and intravenous bisphosphonate therapy. Its pathogenesis is not well understood and its management is difficult.
V. Aftimos +3 more
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Guidelines for bisphosphonate-associated osteonecrosis of the jaw [PDF]
Evidence-Based Dentistry, 2008 This guideline aimed to provide recommendations for the diagnosis of bisphosphonate-associated osteonecrosis of the jaw in both the oncology and osteoporosis patient populations, for dental and medical practitioners including dentists, oral surgeons, oral pathologists, general practitioners and internal medicine specialists.
Derek Richards
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Effect of metformin on inflammation and bone damage in a rat model of medication-related osteonecrosis of the jaw. [PDF]
Eur J Oral SciAbstract This study investigated how chronic metformin administration modulates the cellular profile and inflammatory markers in a zoledronic acid‐based rat model of medication‐related osteonecrosis of the jaw (MRONJ). Male Wistar rats were allocated to different treatments: (i) naïve, (ii) MRONJ (zoledronic acid, 0.2 mg/kg, i.v.
Rabelo LMA +10 more
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The Effects of Bone-Remodeling Therapy on Survival, Pain, and Skeletal Related Events in the Setting of Renal Cell Carcinoma With Bone Metastases: A Multicenter Investigation From a Large Global Health Research Network (TriNetX). [PDF]
Cancer MedIn this retrospective population study containing 139,859 patients, subjects receiving RANK‐ligand inhibitors had improved survival and decreased rates of skeletal‐related events relative to the overall cohort of patients with metastatic bone lesions.
Im BH +9 more
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Time since last intravenous bisphosphonate and risk of osteonecrosis of the jaw in osteoporotic patients [PDF]
Nature CommunicationsMedication-related osteonecrosis of the jaw is a rare but serious condition in which the jawbone fails to heal and becomes necrotic, typically after dental surgery in patients treated with bisphosphonates.
Jung-Hyun Park +6 more
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Endodontic therapy and Medication-related osteonecrosis of the jaw onset: a scoping review and expert opinion-based qualitative meta-synthesis [PDF]
BMC Oral HealthIntroduction Medication-related osteonecrosis of the Jaw (MRONJ) is a serious side effect of bone-modifying agents (BMAs), including bisphosphonates, denosumab, and antiangiogenic drugs.
R. Mauceri +5 more
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Quality of Life Implications of Bisphosphonate-Associated Osteonecrosis of the Jaw [PDF]
The Oncologist, 2011 AbstractPurpose.Potentially debilitating, osteonecrosis of the jaw (ONJ) is an emerging complication of bisphosphonates. However, its effect on quality of life (QoL) is unknown. We determined the ONJ-related QoL decline in a cancer patient cohort.Patients and Methods.Thirty-four cancer patients with bisphosphonate-associated ONJ completed a telephone ...
Rebecca Anne, Miksad +10 more
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