Geranylgeraniol as a Modulator of Mevalonate Pathway Disruption: A Scoping Review of Cellular Mechanisms and Skeletal Outcomes in Osteoporosis Models. [PDF]
Ekeuku SO +4 more
europepmc +1 more source
Bone health in advanced prostate cancer: pathophysiology and management strategies. [PDF]
McKay RR +4 more
europepmc +1 more source
Abstract Premature ovarian insufficiency (POI) and early menopause (EM) affect millions of women worldwide. Compared with normal menopause, they confer a longer duration of estrogen deficiency and are associated not only with a shorter lifespan, but with a reduced healthspan, owing to an increased risk of cardiovascular, skeletal, cognitive and ...
Chiara Benedetto +8 more
wiley +1 more source
Lamina dura thickening in patients on antiresorptive therapy as a radiographic risk indicator of medication-related osteonecrosis of the jaw: a retrospective longitudinal cohort study. [PDF]
Radi S +8 more
europepmc +1 more source
ABSTRACT Background Osteoporosis and sarcopenia frequently coexist in older adults, yet whether denosumab provides muscle‐related benefits beyond bone remains uncertain. We compared denosumab and zoledronic acid across functional, imaging, biologic and study‐defined sarcopenia outcomes based on an Asian Working Group for Sarcopenia (AWGS) 2025‐informed
Xiangwen Li +5 more
wiley +1 more source
Fragility fracture, atypical femoral fracture, and osteonecrosis of jaw after bisphosphonate prescription for three and five years, based on primary and secondary care data in England: nested case-control and cohort studies. [PDF]
Nakafero G +5 more
europepmc +1 more source
ABSTRACT Lethal prostate cancer (PCa) is dominated by treatment‐refractory progression in bone. In this study, we used plasma‐derived extracellular vesicles (EVs) for monitoring the tumour and therapy‐induced changes in the bone tumour microenvironment (bone‐TME) in men with bone metastatic PCa (M1b PCa).
Emanuela Gentile +11 more
wiley +1 more source
Potent bisphosphonate therapy for preventing fractures after denosumab discontinuation in osteoporosis: A GRADE-assessed systematic review and meta-analysis. [PDF]
Shah A +10 more
europepmc +1 more source
The Bisphosphonate Accumulation Index (BAI): A Quantitative Metric for Cumulative Antiresorptive Exposure in Pre-Procedural Dental and Surgical Assessment. [PDF]
Zecca PA +5 more
europepmc +1 more source

