Results 71 to 80 of about 3,946 (192)

Proteinuria After Kidney Transplantation

Pediatric Transplantation, Volume 29, Issue 8, December 2025.
ABSTRACT Proteinuria is a relatively frequent complication in both adults and children after kidney transplantation (40%–80%). It is usually mild and predominantly of tubular origin and is caused mainly by rejection, mTOR inhibitors, or hypertension; however, proteinuria could also be in the nephrotic range and of glomerular origin if caused by the ...
Tomas Seeman, Robert L. Myette, Janusz Feber, Massimiliano Bertacchi, Raja Sekhar Dandamudi, Daniella Levy Erez, Anja Buescher   +6 more
wiley   +1 more source

A computational gene expression score for predicing immune injury in renal allografts [PDF]

, 2017
Background Whole genome microarray meta-analyses of 1030 kidney, heart, lung and liver allograft biopsies identified a common immune response module (CRM) of 11 genes that define acute rejection (AR) across different engrafted tissues.
Bestard Matamoros, Oriol, Damm, Izabella, Hsieh, Szu-Chuan, Roedder, Silke, Sarwal, Minnie M., Sigdel, Tara K., Tran, Tim Q., Vincenti, Flavio   +7 more
core   +1 more source

Next-generation sequencing shows marked rearrangements of BK polyomavirus that favor but are not required for polyomavirus-associated nephropathy

Journal of Clinical Virology, 2020
BKPyV is associated with polyomavirus-associated nephropathy (PVAN), a major cause of graft rejection in kidney transplant recipients (KTRs). Mutations occur in the transcriptional control region (TCR) of BKPyV, but whether they are required for the development of PVAN is not completely understood.
Hanna Liimatainen, Lukas Weseslindtner, Robert Strassl, Stephan W. Aberle, Gregor Bond, Eeva Auvinen   +5 more
openaire   +3 more sources

HLA‐B Leader Dimorphism Predicts BK Polyomavirus Replication After Kidney Transplant

HLA, Volume 106, Issue 5, November 2025.
ABSTRACT BK polyomavirus (BKPyV) and Cytomegalovirus (CMV) often replicate after kidney transplantation, with management limited to reducing immunosuppression and risking rejection. Among genetic factors that may modulate the antiviral response, HLA evolutionary divergence (HED, allowing a greater diversity of antigen presentation) and the HLA‐B leader
Aurélien Aubry, Baptiste Demey, François Helle, Ophélie Fourdinier, Julien Lion, Judith Desoutter, Etienne Brochot, Nicolas Guillaume   +7 more
wiley   +1 more source

Frequency of Polyomavirus BK Infection in Kidney Transplant Patients Suspected to Nephropathy

International Journal of Organ Transplantation Medicine, 2015
Background: Polyomavirus BK is a major cause of nephropathy in immunosuppressed transplanted patients. Non-invasive diagnostic protocols such as molecular detection of polyomavirus BK replication are a useful strategy to predict BK virus-associated ...
M Pakfetrat, R Yaghobi, Z Salmanpoor, J Roozbeh, S Torabinezhad, S Kadkhodaei   +5 more
doaj  

BK virus large T and VP-1 expression in infected human renal allografts [PDF]

, 2017
Objective. We investigated the expression of early and late phase BK virus (BKV) proteins and their interactions with host cell proteins in renal allografts, with ongoing polyomavirus associated nephropathy (PVAN), and correlated this with the nuclear ...
Dürmüller, Ursula, Gudat, Fred, Hirsch, Hans H., Mihatsch, Michael J., Schaub, Stefan, Seemayer, Christian A., Seemayer, Norbert H.   +6 more
core  

BK polyomavirus-associated nephropathy in kidney transplant

Anales de la Facultad de Medicina, 2015
Two documented cases of BK polyomavirus-associated nephropathy (BKVN) seen at Hospital Edgardo Rebagliati Martins, EsSalud, Lima, Peru are reported. Final BKVN diagnosis was confirmed by renal biopsy and electron microscopy study. Case 1: Renal functional deterioration was not controlled despite reduction of immunosuppression and addition of antiviral ...
Méndez Chacón, Pedro, Guzmán Cuba, Nancy, Somocurcio Peralta, José, Vidalón Fernández, Armando, Villacana, Rafael, Méndez Chacón, Carla   +5 more
openaire   +1 more source

Human Polyomavirus BK Genome Analysis in BKPyV Induced Rodent Cell Lines

MicrobiologyOpen, Volume 14, Issue 5, October 2025.
In this study, we analyzed the BK polyomavirus (BKPyV) genome derived from three rodent cell lines established from BKPyV induced tumors. BKPyV derived one cell line had a large deletion. The noncoding control region (NCCR) of BKPyV derived from these cell lines had the same structure as viruses induced tumors.
Setsuko Shioda, Fumio Kasai, Midori Ozawa, Azusa Ohtani, Masashi Iemura, Ken Watanabe, Arihiro Kohara   +6 more
wiley   +1 more source

Cytomegalovirus and polyomavirus BK posttransplant [PDF]

, 2017
Virus replication and progression to disease in transplant patients is determined by patient-, graft- and virus-specific factors. This complex interaction is modulated by the net state of immunosuppression and its impact on virus-specific cellular ...
Binggeli, Simone, Bodaghi, Sohrab, Dumoulin, Alexis, Egli, Adrian, Funk, Georg A., Gosert, Rainer, Hirsch, Hans H., Khanna, Nina, Leuenberger, David   +8 more
core  

Urinary virome perturbations in kidney transplantation [PDF]

, 2018
The human microbiome is important for health and plays a role in essential metabolic functions and protection from certain pathogens. Conversely, dysbiosis of the microbiome is seen in the context of various diseases. Recent studies have highlighted that
Carrie D. Nicora, Kristin Burnum-Johnson, Minnie M. Sarwal, Neil Mercer, Sharvin Nandoe, Sharvin Nandoe, Tara K. Sigdel, Wei-Jun Qian   +7 more
core   +5 more sources