Results 71 to 80 of about 2,798 (150)

Long‐Term Outcomes of BK Viremia in Kidney Transplant Recipients

Clinical Transplantation, Volume 39, Issue 10, October 2025.
ABSTRACT Background BK viremia is associated with worse kidney transplant function and de novo donor‐specific antibodies (DSA), but mortality and graft survival are not impacted in the short‐ and intermediate‐term. The long‐term impact of BK viremia remains unclear.
Srijan Tandukar, Qufei Wu, Sneha Chandrashekar, Divyash Shah, Chienhui Chiang, Kathryn Couch, Jennifer Trofe, Elizabeth M. Sonnenberg, Peter Abt, Mary Ann Lim, Vishnu Potluri, Roy Bloom   +11 more
wiley   +1 more source

BK polyomavirus infection: more than 50 years and still a threat to kidney transplant recipients

Frontiers in Transplantation
BK polyomavirus (BKPyV) is a ubiquitous human polyomavirus and a major infection after kidney transplantation, primarily due to immunosuppression. BKPyV reactivation can manifest as viruria in 30%–40%, viremia in 10%–20%, and BK polyomavirus-associated ...
Sandesh Parajuli, Fahad Aziz, Weixiong Zhong, Arjang Djamali   +3 more
doaj   +1 more source

A Review on JC Virus Infection in Kidney Transplant Recipients

Clinical and Developmental Immunology, 2013
The polyomavirus (PyV), JC virus (JCV), is a small nonenveloped DNA virus that asymptomatically infects about 80% of healthy adults and establishes latency in the kidney tissue.
Serena Delbue, Mariano Ferraresso, Luciana Ghio, Camilla Carloni, Silvia Carluccio, Mirco Belingheri, Alberto Edefonti, Pasquale Ferrante   +7 more
doaj   +1 more source

Regulation of Polyomavirus Transcription by Viral and Cellular Factors

Viruses, 2020
Polyomavirus infection is widespread in the human population. This family of viruses normally maintains latent infection within the host cell but can cause a range of human pathologies, especially in immunocompromised individuals.
June F. Yang, Jianxin You
doaj   +1 more source

Similarities and Differences Between Allogeneic Hematopoietic Cell and Organ Transplantation and What We Can Learn From Each Other to Guide Global Health Strategy

Clinical Transplantation, Volume 39, Issue 10, October 2025.
ABSTRACT Background Allogeneic hematopoietic cell transplantation (HCT) and solid organ transplantation (SOT) have evolved into successful, curative treatments for many severe congenital and acquired diseases. Both use medical products of human origin and should therefore have overarching regulatory frameworks.
Hildegard T. Greinix, Arthur Matas, Mickey B. C. Koh, Lydia Foeken, Nina Worel, Amanda Vinson, Hassan Ibrahim, Deirdre Sawinski, Adriana Seber, Maryam Valapour, Yoshiko Atsuta, Thilo Mengling, John Lake, Thomas Wekerle, Daniel Weisdorf   +14 more
wiley   +1 more source

First‐In‐Human, Randomized, Placebo‐Controlled, SAD and MAD Trial to Evaluate Safety, Tolerability, and PK/PD Modeling of Potravitug in Healthy Adults

Clinical and Translational Science, Volume 18, Issue 8, August 2025.
ABSTRACT BK polyomavirus (BKPyV) affects 10%–30% of kidney‐transplant recipients receiving immunosuppressive therapy, potentially leading to nephropathy, graft dysfunction, graft loss, and increased mortality. Despite the medical need, no targeted therapies exist.
Marcus May, Julia K. Bialek‐Waldmann, Andrew Wright, Scott Gruver, Joshuaine Grant, Barbara Eicher, Jemima Seidenberg, Gerald P. Parzmair, Juergen Beck   +8 more
wiley   +1 more source

Polyomavirus Associated Trichodysplasia Spinulosa in a Pediatric Kidney Transplant Recipient

Pediatric Transplantation, Volume 29, Issue 5, August 2025.
ABSTRACT Background Trichodysplasia spinulosa (TS) is an inconspicuous cutaneous infection caused by a distinct polyoma virus affecting the immunocompromised host. TS is rare in children and can masquerade as other dermatological conditions, causing a delay in diagnosis.
Nivedita Pande, Philippe Leblanc, Barbara Miedzybrodzki, Myriam Carlos, Chelsea Maedler‐Kron, Christos Karatzios, Marie‐Michèle Gaudreault‐Tremblay, Mallory L. Downie   +7 more
wiley   +1 more source

BK and JC polyomavirus co-infection resulting in polyomavirus nephropathy and progressive multifocal leukoencephalopathy at the same time, a case report

Brazilian Journal of Infectious Diseases
John Cunningham Virus (JCV) and BK Virus (BKV) are the most extensively studied Human Polyomaviruses (HPyVs), primarily associated with Progressive Multifocal Leukoencephalopathy (PML) and BKV Nephropathy (BKVN), respectively.
Sébastien Briol, Laura Labriola, Arnaud Devresse, Benoit Kabamba, Valeria Onofrj, Leïla Belkhir   +5 more
doaj   +1 more source

Immunity to Polyomavirus BK Infection: Immune Monitoring to Regulate the Balance between Risk of BKV Nephropathy and Induction of Alloimmunity

Clinical and Developmental Immunology, 2013
Polyomavirus BK-associated nephropathy (PyVAN) is the main infectious cause of allograft damage after kidney transplantation. A number of studies revealed an association between the presence of BKV-specific cellular immunity and BK viral clearance, with ...
Patrizia Comoli, Michela Cioni, Sabrina Basso, Chiara Gagliardone, Leonardo Potenza, Enrico Verrina, Mario Luppi, Marco Zecca, Gian Marco Ghiggeri, Fabrizio Ginevri   +9 more
doaj   +1 more source

Late BK Nephropathy 15 years post kidney transplant following chemotherapy: A case report

IDCases
BK Polyomavirus (BKPyV) is an important risk factor for premature graft loss following kidney transplant. Current practice guidelines recommend screening for BK virus DNA for 2 years after kidney transplant as the risk of BK Polyomavirus associated ...
Anum Hamiduzzaman, Jean Hou, Tram Higgins, Pryce Gaynor, Abhirami Shankar, Erik L. Lum   +5 more
doaj   +1 more source