Results 51 to 60 of about 2,684 (148)

Development of a droplet digital PCR assay for the detection of BK polyomavirus

Microbiology Spectrum
The objective of this study was to establish a more sensitive and specific diagnostic method for detecting plasma BK polyomavirus (BKPyV) DNA load in patients after renal transplantation using droplet digital polymerase chain reaction (ddPCR) and to ...
Lu Ai, Yating Zhao, Chianru Tan, Lu Bai, Gang Huang, Ruizhi Wang, Hao Huang, Xuegao Yu, Yong Guo, Peisong Chen   +9 more
doaj   +1 more source

BK Virus Nephropathy: Prevalence, Impact and Management Strategies

International Journal of Nephrology and Renovascular Disease, 2020
Rajeev Sharma,1,2 Mareena Zachariah3 1School of Medicine, University of Nevada Las Vegas, Las Vegas, NV, USA; 2Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA; 3Department of Nephrology, Wayne State University ...
Sharma R, Zachariah M
doaj  

Polyomavirus BK Nephropathy-Associated Transcriptomic Signatures: A Critical Reevaluation

Transplantation Direct, 2018
Background. Recent work using DNA microarrays has suggested that genes related to DNA replication, RNA polymerase assembly, and pathogen recognition receptors can serve as surrogate tissue biomarkers for polyomavirus BK nephropathy (BKPyVN). Methods.
Ling Pan, MD, Zili Lyu, MD, Benjamin Adam, MD, Gang Zeng, MD, PhD, Zijie Wang, MD, Yuchen Huang, BS, Zahidur Abedin, PhD, Parmjeet Randhawa, MD   +7 more
doaj   +1 more source

BK polyomavirus: latency, reactivation, diseases and tumorigenesis

Frontiers in Cellular and Infection Microbiology, 2023
The identification of the first human polyomavirus BK (BKV) has been over half century, The previous epidemiological and phylogenetic studies suggest that BKV prevailed and co-evolved with humans, leading to high seroprevalence all over the world.
Xianfeng Zhou, Xianfeng Zhou, Xianfeng Zhou, Chunlong Zhu, Hui Li   +4 more
doaj   +1 more source

Full‐House Nephropathy Without Lupus Manifesting During Acute Kidney Allograft Rejection: A Case Report

Clinical Case Reports, Volume 14, Issue 1, January 2026.
ABSTRACT Kidney transplantation increases the survival rate of end‐stage renal disease patients; however, acute rejection and glomerulonephritis, such as the uncommon non‐lupus full‐house nephropathy (NLFHN), can lead to graft dysfunction. NLFHN exhibits a characteristic lupus immunofluorescence pattern in the absence of systemic lupus features, which ...
Tala Pourlak, Farahnoosh Farnood
wiley   +1 more source

Genetic variability of the VP1 gene of BK and JC polyomaviruses in HIV-infected patients [PDF]

Medicinski Podmladak, 2015
Human polyomaviruses, BK virus (BKV) and JC virus (JCV), are world widely distributed in human population. After primary infection, BKV and JCV establish latency in kidneys and upper part of urinary tract. In seropositive healthy individuals asymptomatic
Karalić Danijela, Lazarević Ivana
doaj   +1 more source

BK Polyomavirus‐Associated Nephropathy Complicated by Life‐Threatening Hemorrhagic Pericardial Effusion Following Immunosuppression Reduction in a Kidney Transplant Recipient: A Case Report

Case Reports in Transplantation, Volume 2026, Issue 1, 2026.
Background BK polyomavirus (BKPyV) is an opportunistic infection following kidney transplantation due to immunosuppression. It is a recognized cause of tubulitis and graft dysfunction in kidney transplant recipients (KTRs). Management is challenging because clinicians must balance viral control with the risk of acute rejection.
Hazhir Moradi, Azar Naimi, Firouzeh Moeinzadeh, Richa Sharma   +3 more
wiley   +1 more source

Next-generation sequencing shows marked rearrangements of BK polyomavirus that favor but are not required for polyomavirus-associated nephropathy

Journal of Clinical Virology, 2020
BKPyV is associated with polyomavirus-associated nephropathy (PVAN), a major cause of graft rejection in kidney transplant recipients (KTRs). Mutations occur in the transcriptional control region (TCR) of BKPyV, but whether they are required for the development of PVAN is not completely understood.
Hanna Liimatainen, Lukas Weseslindtner, Robert Strassl, Stephan W. Aberle, Gregor Bond, Eeva Auvinen   +5 more
openaire   +3 more sources

Proteinuria After Kidney Transplantation

Pediatric Transplantation, Volume 29, Issue 8, December 2025.
ABSTRACT Proteinuria is a relatively frequent complication in both adults and children after kidney transplantation (40%–80%). It is usually mild and predominantly of tubular origin and is caused mainly by rejection, mTOR inhibitors, or hypertension; however, proteinuria could also be in the nephrotic range and of glomerular origin if caused by the ...
Tomas Seeman, Robert L. Myette, Janusz Feber, Massimiliano Bertacchi, Raja Sekhar Dandamudi, Daniella Levy Erez, Anja Buescher   +6 more
wiley   +1 more source

Frequency of Polyomavirus BK Infection in Kidney Transplant Patients Suspected to Nephropathy

International Journal of Organ Transplantation Medicine, 2015
Background: Polyomavirus BK is a major cause of nephropathy in immunosuppressed transplanted patients. Non-invasive diagnostic protocols such as molecular detection of polyomavirus BK replication are a useful strategy to predict BK virus-associated ...
M Pakfetrat, R Yaghobi, Z Salmanpoor, J Roozbeh, S Torabinezhad, S Kadkhodaei   +5 more
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