Results 61 to 70 of about 2,798 (150)

From a 1:4096 Baseline to 1:128 on the Day of Transplantation: Challenging the Titer Barrier in ABO‐Incompatible Kidney Transplantation

Case Reports in Medicine, Volume 2026, Issue 1, 2026.
ABO‐incompatible (ABOi) kidney transplantation protocols universally mandate reducing circulating isoagglutinin titers to ≤ 1:32 on the day of surgery (Day 0) to prevent hyperacute rejection, rendering Day 0 titers ≥ 1:64 a widely accepted contraindication.
Wipada Songwattana, Veerapat Wattanasatja, Punnawit Laungchuaychok, Kornrawee Sawasdichai, Nisarat Rungsawang, Salin Wattanatorn, Gantapong Sainont, Chanchalee Nopparatana, Chayada Wattanaburanon, Thunyatorn Wuttiputhanun, Asada Leelahavanichkul, Natavudh Townamchai, Yingyos Avihingsanon, Suwasin Udomkarnjananun, Lothar Bergmann   +14 more
wiley   +1 more source

JC Polyomavirus-Associated Nephropathy Case Report: Clinical and Laboratory Learning

British Journal of Biomedical Science
IntroductionJohn Cunningham (JC) virus is commonly associated with progressive multifocal leukoencephalopathy. However, this polyomavirus can also be a rare etiological agent of nephropathy in renal transplant recipients.
Rachael M. Tomb, Siobhan K. McManus, David Kipgen, Sawsan Yaqub, Sally Taylor, Rory N. Gunson   +5 more
doaj   +1 more source

Renal Allograft Biopsies with Polyomavirus BK Nephropathy: Turin Transplant Center, 2015–19

Viruses, 2020
Background: In kidney transplant patients, polyomavirus-associated nephropathy (PVAN) represents a serious complication; the key factor for the development of PVAN is immunosuppression level and modulation of anti-rejection treatment represents the first
Elisa Zanotto, Anna Allesina, Antonella Barreca, Francesca Sidoti, Ester Gallo, Paolo Bottino, Marco Iannaccone, Gabriele Bianco, Luigi Biancone, Rossana Cavallo, Cristina Costa   +10 more
doaj   +1 more source

Next-generation sequencing shows marked rearrangements of BK polyomavirus that favor but are not required for polyomavirus-associated nephropathy

Journal of Clinical Virology, 2020
BKPyV is associated with polyomavirus-associated nephropathy (PVAN), a major cause of graft rejection in kidney transplant recipients (KTRs). Mutations occur in the transcriptional control region (TCR) of BKPyV, but whether they are required for the development of PVAN is not completely understood.
Hanna Liimatainen, Lukas Weseslindtner, Robert Strassl, Stephan W. Aberle, Gregor Bond, Eeva Auvinen   +5 more
openaire   +3 more sources

Manufacturing and clinical applications of non‐CAR‐T immune effector cells

Transfusion, Volume 66, Issue S2, Page S29-S44, September 2026.
Thane Kubik, Theodros Mamo, David H. McKenna   +2 more
wiley   +1 more source

Proteinuria After Kidney Transplantation

Pediatric Transplantation, Volume 29, Issue 8, December 2025.
ABSTRACT Proteinuria is a relatively frequent complication in both adults and children after kidney transplantation (40%–80%). It is usually mild and predominantly of tubular origin and is caused mainly by rejection, mTOR inhibitors, or hypertension; however, proteinuria could also be in the nephrotic range and of glomerular origin if caused by the ...
Tomas Seeman, Robert L. Myette, Janusz Feber, Massimiliano Bertacchi, Raja Sekhar Dandamudi, Daniella Levy Erez, Anja Buescher   +6 more
wiley   +1 more source

Aryl hydrocarbon receptor expression by macrophages and lymphocytes within infiltrates in BK polyomavirus associated nephropathy

Transplant Immunology, 2018
BK virus nephropathy (BKPyVN) is a major complication after renal transplantation. Little is known about the intra renal immune response during BKPyVN. The role of macrophages remains elusive. The activation of aryl hydrocarbon receptor (AHR) - a transcription factor involved in drug metabolism - plays a key role in inflammation and viral tolerance ...
Yassine Bouatou, Geurt Stokman, Nike Claessen, Joris J.T.H. Roelofs, Frederike Bemelman, Jesper Kers, Sandrine Florquin   +6 more
openaire   +4 more sources

A delicate balance between rejection and BK polyomavirus associated nephropathy; A retrospective cohort study in renal transplant recipients. [PDF]

PLoS One, 2017
The immunosuppressive agents mycophenolate acid (MPA) and tacrolimus (Tac) are associated with a higher incidence of BK polyomavirus nephropathy (BKPyVAN). In this observational retrospective cohort study, the frequency of BK polyomavirus (BKPyV) complications over a 24-month period was studied.358 renal transplant recipients (RTR) treated with MPA ...
Gard L, van Doesum W, Niesters HGM, van Son WJ, Diepstra A, Stegeman CA, Groen H, Riezebos-Brilman A, Sanders JS.   +8 more
europepmc   +6 more sources

HLA‐B Leader Dimorphism Predicts BK Polyomavirus Replication After Kidney Transplant

HLA, Volume 106, Issue 5, November 2025.
ABSTRACT BK polyomavirus (BKPyV) and Cytomegalovirus (CMV) often replicate after kidney transplantation, with management limited to reducing immunosuppression and risking rejection. Among genetic factors that may modulate the antiviral response, HLA evolutionary divergence (HED, allowing a greater diversity of antigen presentation) and the HLA‐B leader
Aurélien Aubry, Baptiste Demey, François Helle, Ophélie Fourdinier, Julien Lion, Judith Desoutter, Etienne Brochot, Nicolas Guillaume   +7 more
wiley   +1 more source

Human Polyomavirus BK Genome Analysis in BKPyV Induced Rodent Cell Lines

MicrobiologyOpen, Volume 14, Issue 5, October 2025.
In this study, we analyzed the BK polyomavirus (BKPyV) genome derived from three rodent cell lines established from BKPyV induced tumors. BKPyV derived one cell line had a large deletion. The noncoding control region (NCCR) of BKPyV derived from these cell lines had the same structure as viruses induced tumors.
Setsuko Shioda, Fumio Kasai, Midori Ozawa, Azusa Ohtani, Masashi Iemura, Ken Watanabe, Arihiro Kohara   +6 more
wiley   +1 more source