Results 61 to 70 of about 2,684 (148)

Renal Allograft Biopsies with Polyomavirus BK Nephropathy: Turin Transplant Center, 2015–19

Viruses, 2020
Background: In kidney transplant patients, polyomavirus-associated nephropathy (PVAN) represents a serious complication; the key factor for the development of PVAN is immunosuppression level and modulation of anti-rejection treatment represents the first
Elisa Zanotto, Anna Allesina, Antonella Barreca, Francesca Sidoti, Ester Gallo, Paolo Bottino, Marco Iannaccone, Gabriele Bianco, Luigi Biancone, Rossana Cavallo, Cristina Costa   +10 more
doaj   +1 more source

BK polyomavirus-associated nephropathy in kidney transplant

Anales de la Facultad de Medicina, 2015
Two documented cases of BK polyomavirus-associated nephropathy (BKVN) seen at Hospital Edgardo Rebagliati Martins, EsSalud, Lima, Peru are reported. Final BKVN diagnosis was confirmed by renal biopsy and electron microscopy study. Case 1: Renal functional deterioration was not controlled despite reduction of immunosuppression and addition of antiviral ...
Méndez Chacón, Pedro, Guzmán Cuba, Nancy, Somocurcio Peralta, José, Vidalón Fernández, Armando, Villacana, Rafael, Méndez Chacón, Carla   +5 more
openaire   +1 more source

HLA‐B Leader Dimorphism Predicts BK Polyomavirus Replication After Kidney Transplant

HLA, Volume 106, Issue 5, November 2025.
ABSTRACT BK polyomavirus (BKPyV) and Cytomegalovirus (CMV) often replicate after kidney transplantation, with management limited to reducing immunosuppression and risking rejection. Among genetic factors that may modulate the antiviral response, HLA evolutionary divergence (HED, allowing a greater diversity of antigen presentation) and the HLA‐B leader
Aurélien Aubry, Baptiste Demey, François Helle, Ophélie Fourdinier, Julien Lion, Judith Desoutter, Etienne Brochot, Nicolas Guillaume   +7 more
wiley   +1 more source

Human Polyomavirus BK Genome Analysis in BKPyV Induced Rodent Cell Lines

MicrobiologyOpen, Volume 14, Issue 5, October 2025.
In this study, we analyzed the BK polyomavirus (BKPyV) genome derived from three rodent cell lines established from BKPyV induced tumors. BKPyV derived one cell line had a large deletion. The noncoding control region (NCCR) of BKPyV derived from these cell lines had the same structure as viruses induced tumors.
Setsuko Shioda, Fumio Kasai, Midori Ozawa, Azusa Ohtani, Masashi Iemura, Ken Watanabe, Arihiro Kohara   +6 more
wiley   +1 more source

JC Polyomavirus-Associated Nephropathy Case Report: Clinical and Laboratory Learning

British Journal of Biomedical Science
IntroductionJohn Cunningham (JC) virus is commonly associated with progressive multifocal leukoencephalopathy. However, this polyomavirus can also be a rare etiological agent of nephropathy in renal transplant recipients.
Rachael M. Tomb, Siobhan K. McManus, David Kipgen, Sawsan Yaqub, Sally Taylor, Rory N. Gunson   +5 more
doaj   +1 more source

Long‐Term Outcomes of BK Viremia in Kidney Transplant Recipients

Clinical Transplantation, Volume 39, Issue 10, October 2025.
ABSTRACT Background BK viremia is associated with worse kidney transplant function and de novo donor‐specific antibodies (DSA), but mortality and graft survival are not impacted in the short‐ and intermediate‐term. The long‐term impact of BK viremia remains unclear.
Srijan Tandukar, Qufei Wu, Sneha Chandrashekar, Divyash Shah, Chienhui Chiang, Kathryn Couch, Jennifer Trofe, Elizabeth M. Sonnenberg, Peter Abt, Mary Ann Lim, Vishnu Potluri, Roy Bloom   +11 more
wiley   +1 more source

Similarities and Differences Between Allogeneic Hematopoietic Cell and Organ Transplantation and What We Can Learn From Each Other to Guide Global Health Strategy

Clinical Transplantation, Volume 39, Issue 10, October 2025.
ABSTRACT Background Allogeneic hematopoietic cell transplantation (HCT) and solid organ transplantation (SOT) have evolved into successful, curative treatments for many severe congenital and acquired diseases. Both use medical products of human origin and should therefore have overarching regulatory frameworks.
Hildegard T. Greinix, Arthur Matas, Mickey B. C. Koh, Lydia Foeken, Nina Worel, Amanda Vinson, Hassan Ibrahim, Deirdre Sawinski, Adriana Seber, Maryam Valapour, Yoshiko Atsuta, Thilo Mengling, John Lake, Thomas Wekerle, Daniel Weisdorf   +14 more
wiley   +1 more source

First‐In‐Human, Randomized, Placebo‐Controlled, SAD and MAD Trial to Evaluate Safety, Tolerability, and PK/PD Modeling of Potravitug in Healthy Adults

Clinical and Translational Science, Volume 18, Issue 8, August 2025.
ABSTRACT BK polyomavirus (BKPyV) affects 10%–30% of kidney‐transplant recipients receiving immunosuppressive therapy, potentially leading to nephropathy, graft dysfunction, graft loss, and increased mortality. Despite the medical need, no targeted therapies exist.
Marcus May, Julia K. Bialek‐Waldmann, Andrew Wright, Scott Gruver, Joshuaine Grant, Barbara Eicher, Jemima Seidenberg, Gerald P. Parzmair, Juergen Beck   +8 more
wiley   +1 more source

Aryl hydrocarbon receptor expression by macrophages and lymphocytes within infiltrates in BK polyomavirus associated nephropathy

Transplant Immunology, 2018
BK virus nephropathy (BKPyVN) is a major complication after renal transplantation. Little is known about the intra renal immune response during BKPyVN. The role of macrophages remains elusive. The activation of aryl hydrocarbon receptor (AHR) - a transcription factor involved in drug metabolism - plays a key role in inflammation and viral tolerance ...
Yassine Bouatou, Geurt Stokman, Nike Claessen, Joris J.T.H. Roelofs, Frederike Bemelman, Jesper Kers, Sandrine Florquin   +6 more
openaire   +4 more sources

Polyomavirus Associated Trichodysplasia Spinulosa in a Pediatric Kidney Transplant Recipient

Pediatric Transplantation, Volume 29, Issue 5, August 2025.
ABSTRACT Background Trichodysplasia spinulosa (TS) is an inconspicuous cutaneous infection caused by a distinct polyoma virus affecting the immunocompromised host. TS is rare in children and can masquerade as other dermatological conditions, causing a delay in diagnosis.
Nivedita Pande, Philippe Leblanc, Barbara Miedzybrodzki, Myriam Carlos, Chelsea Maedler‐Kron, Christos Karatzios, Marie‐Michèle Gaudreault‐Tremblay, Mallory L. Downie   +7 more
wiley   +1 more source