Results 101 to 110 of about 2,252 (197)

A Phase I Study Evaluating Safety and Tolerability of Viral‐Specific T Cells Against BK‐Virus in Adult Kidney Transplant Recipients

Journal of Medical Virology, Volume 97, Issue 4, April 2025.
ABSTRACT BK polyomavirus (BKPyV) poses a significant threat to kidney transplant recipients (KTR). Current management primarily involves reducing immunosuppression, which increases the risk of rejection. Cell‐based immunotherapy with virus‐specific T cells (VST) has emerged as an alternative approach for treating BKPyV in KTRs. This single‐center phase
Lucy Ptak, Ross O. Meyers, Olga Radko‐Ganz, Kimberly A. McDowell, Margaret Jorgenson, Maggie Chilsen, Didier Mandelbrot, Jacques Galipeau, Sandesh Parajuli   +8 more
wiley   +1 more source

Transferrin Saturation Can Serve as a Novel Biomarker for Predicting the Occurrence and Development of BK Virus‐Related Nephropathy After Kidney Transplantation

Journal of Medical Virology, Volume 97, Issue 3, March 2025.
ABSTRACT BK polyomavirus reactivation is a common complication after kidney transplantation, affecting the long‐term survival of the transplanted kidney. However, it is unclear whether iron levels affect BKPyV reactivation after kidney transplantation.
Yongchuang Yan, Zhigang Wang, Yonghua Feng, Yang Qiu, Yuanbo Qi, Fumin Cheng, Yi Feng, Di Zhang, Guiwen Feng, Wenjun Shang   +9 more
wiley   +1 more source

Reactivation of BK Polyomavirus in Urine Cytology Is Not Associated with Urothelial Cell Carcinoma

Viruses, 2020
BK polyomavirus (BKPyV) has been associated with some high-grade and special urothelial cell carcinoma (UCC) subtypes in immunosuppressed patients. Here, we evaluated the relationship of BKPyV-positive urine cytology specimens (UCS) with UCC.
Faisal Klufah, Ghalib Mobaraki, Axel zur Hausen, Iryna V. Samarska   +3 more
doaj   +1 more source

Glibenclamide inhibits BK polyomavirus infection in kidney cells through CFTR blockade [PDF]

, 2020
BK polyomavirus (BKPyV) is a ubiquitous pathogen in the human population that is asymptomatic in healthy individuals, but can be life-threatening in those undergoing kidney transplant.
Antoni, M, Loundras, E-A, Macdonald, A, Mankouri, J, Morgan, EL, Panou, M-M, Wasson, CW, Welberry-Smith, M   +7 more
core   +1 more source

Association of Posttransplant Circulating 25‐Hydroxyvitamin D and Late‐Onset Infections Among Kidney Transplant Recipients: The Wisconsin Allograft Recipient Database (WisARD)

Transplant Infectious Disease, Volume 27, Issue 2, March/April 2025.
Lower posttransplant circulating 25(OH)D level is significantly associated with a higher incidence of late‐onset infection among kidney transplant recipients, especially urinary tract infections in male recipients. ABSTRACT Introduction Late‐onset infection occurring more than 6 months after transplantation is a major threat to the long‐term survival ...
Zhongyu Yuan, Michal L. Melamed, Sandesh Parajuli, Didier Mandelbrot, Brad C. Astor   +4 more
wiley   +1 more source

Tumor Necrosis Factor-Alpha Inhibits the Replication of Patient-Derived Archetype BK Polyomavirus While Activating Rearranged Strains [PDF]

To date, no drugs are approved for BK polyomavirus (BKPyV) reactivation, a major cause of nephropathy after kidney transplantation. Recently, tumor necrosis factor‐α (TNF‐α) blockade has been proposed as a promising therapy, however, the effect of TNF ...
Feld, Pascal, Fliser, Danilo, Gasparoni, Gilles, Gläser, Lars, Janssen, Martin, Kattler-Lackes, Kathrin, Klinz, Jonas, Laue, Michael, Lauterbach, Marcel A., Lauterbach-Rivière, Lise, Lohse, Stefan, Möller, Lars, Rahmann, Sven, Schmit, David, Schüssler, Jessica, Smola, Sigrun, Sternjakob, Anna, Stöckle, Michael, Thuringer, Lucia, Toews, Lina Kathrin, Walter, Jörn   +20 more
core   +1 more source

Single-cell analysis reveals host S phase drives large T antigen expression during BK polyomavirus infection.

PLoS Pathogens
BK polyomavirus (BKPyV) is a major cause of kidney transplant failure, for which there are no antivirals. The current model is that BKPyV expresses TAg (large T antigen) early during infection, promoting cells to enter S phase where the viral DNA can ...
Jason M Needham, Sarah E Perritt, Sunnie R Thompson   +2 more
doaj   +1 more source

Pre-transplant immune factors may be associated with BK polyomavirus reactivation in kidney transplant recipients.

PLoS ONE, 2017
BK polyomavirus (BKPyV) reactivation in kidney transplant recipients can lead to allograft damage and loss. The elements of the adaptive immune system that are permissive of reactivation and responsible for viral control remain incompletely described. We
David DeWolfe, Jinal Gandhi, Matthew R Mackenzie, Thomas A Broge, Evelyn Bord, Amaara Babwah, Didier A Mandelbrot, Martha Pavlakis, Francesca Cardarelli, Raphael Viscidi, Anil Chandraker, Chen S Tan   +11 more
doaj   +1 more source

Additional file 1 of The risk factors associated with post-transplantation BKPyV nephropathy and BKPyV DNAemia: a prospective study in kidney transplant recipients

Supplementary Material ...
Lorant, Camilla, Zigmantaviciute, Justina, Ali, Naima, Bonnevier, Ursa, Tejde, Mattias, von Zur-Mühlen, Bengt, Eriksson, Britt-Marie, Bergqvist, Anders, Westman, Gabriel   +8 more
openaire   +1 more source

BK polyomavirus in Kidney transplant recipients: screening, monitoring and clinical management

Brazilian Journal of Nephrology, 2014
BK polyomavirus (BKPyV) is a causal agent of nephropathy, ureteral stenosis and hemorrhagic cystitis in kidney transplant recipients, and is considered an important emerging disease in transplantation.
Rafael Brandão Varella, Jorge Reis Almeida, Patrícia de Fátima Lopes, Jorge Paulo Strogoff de Matos, Paulo Menezes, Jocemir Ronaldo Lugon   +5 more
doaj   +1 more source