Results 81 to 90 of about 2,252 (197)

JC Polyomavirus Infection of Primary Human Renal Epithelial Cells Is Controlled by a Type I IFN-Induced Response

mBio, 2016
The JC and BK human polyomaviruses (JCPyV and BKPyV, respectively) establish lifelong persistent infections in the kidney. In immunosuppressed individuals, JCPyV causes progressive multifocal leukoencephalopathy (PML), a fatal neurodegenerative disease ...
Benedetta Assetta, Marco De Cecco, Bethany O’Hara, Walter J. Atwood   +3 more
doaj   +1 more source

Polyomavirus BK Genome Comparison Shows High Genetic Diversity in Kidney Transplant Recipients Three Months after Transplantation

Viruses, 2022
BK polyomavirus (BKPyV) is a human DNA virus generally divided into twelve subgroups based on the genetic diversity of Viral Protein 1 (VP1). BKPyV can cause polyomavirus-associated nephropathy (PVAN) after kidney transplantation.
Olga Mineeva-Sangwo, Joan Martí-Carreras, Evert Cleenders, Dirk Kuypers, Piet Maes, Graciela Andrei, Maarten Naesens, Robert Snoeck   +7 more
doaj   +1 more source

Organ Transplantation: Current Status, Challenges, and Future Prospects

MedComm, Volume 7, Issue 1, January 2026.
Organ transplantation success relies on precise modulation of the alloimmune response across distinct temporal phases of rejection. Hyperacute rejection results from preformed antibodies activating complement and causing thrombosis, while acute rejection involves T cell‐ and antibody‐mediated mechanisms that drive endothelial activation and ...
Xinqiang Li, Ruidong Ding, Jinzhen Cai
wiley   +1 more source

Humán papillomavírus és humán herpeszvírusok kóroki szerepének molekuláris vizsgálata = Molecular analysis of pathogenic role of human papilloma virus and human herpesviruses [PDF]

, 2013
Vesetranszplantáltak mintáiban a humán herpeszvírus 6A dominanciáját, és a humán cytomegalovírussal megegyező gyakoriságát találtuk. Az új KI és WU polyomavírusok jelenlétét mi írtuk le először vizeletből, a HPyV9-et légúti mintákból.
Csoma, Eszter, Gergely, Lajos, Murvai, Melinda, Szarka, Krisztina Zsuzsanna   +3 more
core  

Temporal Proteomic Analysis of BK Polyomavirus Infection Reveals Virus-Induced G2 Arrest and Highly Effective Evasion of Innate Immune Sensing. [PDF]

, 2019
BK polyomavirus (BKPyV) is a small DNA virus that establishes a life-long persistent infection in the urinary tract of most people. BKPyV is known to cause severe morbidity in renal transplant recipients and can lead to graft rejection.
Antrobus, Robin, Caller, Laura G, Crump, Colin M, Davies, Colin TR, Lehner, Paul J, Weekes, Michael P   +5 more
core   +1 more source

Towards uncovering polyomavirus-carrying human cancers:pathology and implications for tumorigenesis [PDF]

, 2022
Cancer is one of the leading causes of death in humans worldwide. The most common risk factors for cancer include exposure to chemicals, smoking, alcohol, radiation, and inherited genetic mutations.
Klufah, Faisal Mahdi
core   +2 more sources

The Role of APOBEC3B in Cancer: Mechanisms, Clinical Challenges, and Therapeutic Opportunities

Human Mutation, Volume 2026, Issue 1, 2026.
Apolipoprotein B mRNA editing enzyme catalytic polypeptide‐like 3B (APOBEC3B, A3B) is a key cytidine deaminase that induces genomic instability and clonal evolution in diverse malignancies. Although A3B plays a key role in the onset and advancement of various cancers, a comprehensive model bridging its multifaceted mechanisms and clinical translation ...
Fengfeng Zhou, Weili Chen, Liqin Ruan, Run Shi   +3 more
wiley   +1 more source

Salivary and Serum Cytokine Concentrations in Kidney Transplantation: A Prospective Study

Oral Diseases, Volume 31, Issue 12, Page 3474-3481, December 2025.
ABSTRACT Background Kidney transplant recipients (KTRs) experience immune modulation, which may lead to graft rejection and other adverse outcomes. Although serum cytokines are well‐established systemic immune markers, the role of salivary biomarkers has never been reported in the literature.
Luciano Miziara, Marcio Augusto de Oliveira, Debora Macedo, Ligia Pierrotti, Fabiana Agena, Elias David‐Neto, Aluísio Cotrim Segurado, Rodrigo Zerbinati, Marina Gallottini, Paulo Braz‐Silva, Fabiana Martins   +10 more
wiley   +1 more source

Allogeneic CD4 T Cells Sustain Effective BK Polyomavirus-Specific CD8 T Cell Response in Kidney Transplant Recipients

Kidney International Reports
Introduction: BK polyomavirus-associated nephropathy (BKPyVAN) is a significant complication in kidney transplant recipients (KTRs), associated with a higher level of plasmatic BK polyomavirus (BKPyV) replication and leading to poor graft survival ...
Manon Dekeyser, Marie-Ghislaine de Goër de Herve, Houria Hendel-Chavez, Romain Lhotte, Ivan Scriabine, Karen Bargiel, Emmanuelle Boutin, Florence Herr, Jean-Luc Taupin, Yassine Taoufik, Antoine Durrbach   +10 more
doaj   +1 more source

Non-permissive human conventional CD1c+ dendritic cells enable trans-infection of human primary renal tubular epithelial cells and protect BK polyomavirus from neutralization.

PLoS Pathogens, 2021
The BK polyomavirus (BKPyV) is a ubiquitous human virus that persists in the renourinary epithelium. Immunosuppression can lead to BKPyV reactivation in the first year post-transplantation in kidney transplant recipients (KTRs) and hematopoietic stem ...
Mathieu Sikorski, Flora Coulon, Cécile Peltier, Cécile Braudeau, Alexandra Garcia, Matthieu Giraud, Karine Renaudin, Christine Kandel-Aznar, Steven Nedellec, Philippe Hulin, Julien Branchereau, Joëlle Véziers, Pauline Gaboriaud, Antoine Touzé, Julien Burlaud-Gaillard, Régis Josien, Dorian McIlroy, Céline Bressollette-Bodin, Franck Halary   +18 more
doaj   +1 more source