Results 81 to 90 of about 1,873 (184)

The Role of APOBEC3B in Cancer: Mechanisms, Clinical Challenges, and Therapeutic Opportunities

Human Mutation, Volume 2026, Issue 1, 2026.
Apolipoprotein B mRNA editing enzyme catalytic polypeptide‐like 3B (APOBEC3B, A3B) is a key cytidine deaminase that induces genomic instability and clonal evolution in diverse malignancies. Although A3B plays a key role in the onset and advancement of various cancers, a comprehensive model bridging its multifaceted mechanisms and clinical translation ...
Fengfeng Zhou, Weili Chen, Liqin Ruan, Run Shi   +3 more
wiley   +1 more source

Salivary and Serum Cytokine Concentrations in Kidney Transplantation: A Prospective Study

Oral Diseases, Volume 31, Issue 12, Page 3474-3481, December 2025.
ABSTRACT Background Kidney transplant recipients (KTRs) experience immune modulation, which may lead to graft rejection and other adverse outcomes. Although serum cytokines are well‐established systemic immune markers, the role of salivary biomarkers has never been reported in the literature.
Luciano Miziara, Marcio Augusto de Oliveira, Debora Macedo, Ligia Pierrotti, Fabiana Agena, Elias David‐Neto, Aluísio Cotrim Segurado, Rodrigo Zerbinati, Marina Gallottini, Paulo Braz‐Silva, Fabiana Martins   +10 more
wiley   +1 more source

Simultaneous BK Polyomavirus (BKPyV)-associated nephropathy and hemorrhagic cystitis after living donor kidney transplantation

, 2016
BK polyomavirus (BKPyV) commonly reactivates after kidney transplantation, and can cause polyomavirus-associated nephropathy (PyVAN), whereas after allogeneic stem cell transplantation the most frequent manifestation of BKPyV is polyomavirus-associated ...
Ortiz, F., Hirsch, H. H., Lautenschlager, I., Raisanen-Sokolowski, A., Mannonen, L., Wernli, M., Helantera, I., Lempinen, M., Auvinen, E.   +8 more
core   +1 more source

Time-lapse imaging and TEER-monitoring throughout BKPyV replication.

, 2023
(A) Time-lapse imaging of mock infected and BKPyV infected (MOI 1) polarized RPTECs. DNA of permeabilized cells is stained with CellTox dye. Representative images from two independent experiments at 24, 48, 60, 72, 96 and 120 hpi are shown.
Christine Hanssen Rinaldo (16892416), Elias Myrvoll Lorentzen (16892410), Stian Henriksen (16892413)   +2 more
core   +1 more source

Allogeneic CD4 T Cells Sustain Effective BK Polyomavirus-Specific CD8 T Cell Response in Kidney Transplant Recipients

Kidney International Reports
Introduction: BK polyomavirus-associated nephropathy (BKPyVAN) is a significant complication in kidney transplant recipients (KTRs), associated with a higher level of plasmatic BK polyomavirus (BKPyV) replication and leading to poor graft survival ...
Manon Dekeyser, Marie-Ghislaine de Goër de Herve, Houria Hendel-Chavez, Romain Lhotte, Ivan Scriabine, Karen Bargiel, Emmanuelle Boutin, Florence Herr, Jean-Luc Taupin, Yassine Taoufik, Antoine Durrbach   +10 more
doaj   +1 more source

Advances in Single‐Cell Sequencing for Infectious Diseases: Progress and Perspectives

Advanced Science, Volume 12, Issue 32, August 28, 2025.
Single‐cell sequencing technologies uncover novel, unknown, and emergent features of many diseases. This review describes recent progress of single‐cell sequencing technologies and their applications in infectious diseases, summarizes the underlying commonalities of different infections and discusses future research directions, facilitating the ...
Mengyuan Lyu, Yang Liu, Jian Zhou, Hongli Lai, Hongxia Ruan, Dongsheng Wu, Shun Zhu, Xudong Zhou, Wananqi Ma, Yuchen Huang, Shuting Lei, Han Luo, Jie Chen, Binwu Ying   +13 more
wiley   +1 more source

Viral urological infections in kidney transplantation: BK polyomavirus (BKPyV)-associated diseases

, 2021
Viral infections continue to be prevalent and a major problem in kidney transplant recipients. One of the most significant viruses for renal transplant patients is BK polyomavirus (BKPyV), the cause of BKPyVassociated nephropathy (BKVAN). BKVAN is seen in ca. 5% of renal transplant recipients and can lead to chronic allograft failure or even graft loss
Schneidewind, Laila, Kranz, Jennifer
openaire   +1 more source

BKPyV induced cytopathic effects and cell death in polarized RPTECs.

, 2023
(A) Phase-contrast images of mock infected and BKPyV infected RPTECs (MOI 3) from 24 to 120 hpi. Representative images from two independent experiments are shown. Scale bar 100 μm.
Christine Hanssen Rinaldo (16892416), Elias Myrvoll Lorentzen (16892410), Stian Henriksen (16892413)   +2 more
core   +1 more source

First‐In‐Human, Randomized, Placebo‐Controlled, SAD and MAD Trial to Evaluate Safety, Tolerability, and PK/PD Modeling of Potravitug in Healthy Adults

Clinical and Translational Science, Volume 18, Issue 8, August 2025.
ABSTRACT BK polyomavirus (BKPyV) affects 10%–30% of kidney‐transplant recipients receiving immunosuppressive therapy, potentially leading to nephropathy, graft dysfunction, graft loss, and increased mortality. Despite the medical need, no targeted therapies exist.
Marcus May, Julia K. Bialek‐Waldmann, Andrew Wright, Scott Gruver, Joshuaine Grant, Barbara Eicher, Jemima Seidenberg, Gerald P. Parzmair, Juergen Beck   +8 more
wiley   +1 more source

BKPyV Dunlop transcriptome atlas, watch plots.

, 2022
A-C. Watch plots indicating all identified transcripts in BKPyV Dunlop. (A) and (B) show transcripts that were identified in both dRNAseq and SMRTseq data, while (C) shows transcripts identified in dRNAseq only.
Michael J. Imperiale (12334399), Chandreyee Datta (12334396), Gabriel J. Starrett (2741878), Matthew Meyerson (24538), Wei Zou (107458), Thomas C. Frost (12334393), Shobha Vasudevan (8433183), James A. DeCaprio (8597283), Jason Nomburg (8597259)   +8 more
core   +1 more source