Results 171 to 180 of about 2,252 (197)

Discriminating between JCPyV and BKPyV in Urinary Virome Data Sets [PDF]

Viruses, 2021
Polyomaviruses are abundant in the human body. The polyomaviruses JC virus (JCPyV) and BK virus (BKPyV) are common viruses in the human urinary tract. Prior studies have estimated that JCPyV infects between 20 and 80% of adults and that BKPyV infects between 65 and 90% of individuals by age 10.
Rita Mormando, Alan J Wolfe, Catherine Putonti   +2 more
exaly   +5 more sources

Longitudinal monitoring of BKPyV miRNA levels in kidney transplant recipients with BKPyV‐related pathology reflects viral DNA levels and remain high in viremia patients after clearance of viral DNA

Transplant Infectious Disease, 2022
AbstractIntroductionIt is unclear whether polyomavirus BK (BKPyV) microribonucleic acid (miRNA) measurement has additional diagnostic and predictive value in kidney transplant recipients (KTR) as compared to current methods of monitoring BKPyV DNA loads.Patients and methodsA retrospective, longitudinal study was performed in 30 KTR with BKPyV viruria ...
Willem B Van Doesum, Lilli Gard, Jacob van den Born   +2 more
exaly   +4 more sources

The role of the DE and EF loop of BKPyV VP1 in the serological cross-reactivity between subtypes

Virus Research, 2023
BK virus (BKPyV) is a causative agent of BKPyV-associated nephropathy and graft rejections in kidney transplant patients. It establishes persistent infection in the kidneys, which can lead to reactivation in an immunosuppressed state or transmission to kidney recipients. Complications in the case of donor-derived infections can be caused by differences
Alžbeta Hejtmankova, Hana Španielová   +1 more
exaly   +4 more sources

Characteristics of polyomavirus BK (BKPyV) infection in primary human urothelial cells

Virology, 2013
High-level polyomavirus BK (BKPyV) replication in urothelial cells is a hallmark of polyomavirus-associated hemorrhagic cystitis (PyVHC), a painful condition affecting bone marrow transplant recipients. In kidney transplant recipients, replication in tubular epithelial cells is associated with overt disease whereas high-level urothelial replication is ...
Stig Linder, Hans H Hirsch, Christine Hanssen Rinaldo   +2 more
exaly   +4 more sources

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Infection by human polyomaviruses JCPyV and BKPyV in blood donors of Argentina

Vox Sanguinis, 2023
AbstractBackground and ObjectivesA spectrum of blood‐borne infectious agents may be transmitted through transfusion of blood components from asymptomatic donors. Despite the persistence of polyomaviruses in blood cells, no studies have been conducted in Argentina to assess the risk of transfusion infection.Materials and MethodsWe investigated BKPyV and
María C. Frutos, Sebastián Blanco, Nubia Yandar Barahona, Arnaldo Mangeaud, Luis Horacio Carrizo, Sandra Gallego   +5 more
openaire   +3 more sources

Effect of Leflunomide, Cidofovir and Ciprofloxacin on replication of BKPyV in a salivary gland in vitro culture system [PDF]

Antiviral Research, 2015
BK polyomavirus (BKPyV) is a known kidney tropic virus that has been detected at high levels in HIV-associated salivary gland disease (HIV-SGD), one of the most important AIDS associated oral lesions. BKPyV has been detected in HIV-SGD patient saliva and replicates in salivary gland cells in vitro.
Liesl K Jeffers-Francis, Raquel Burger-Calderon, Jennifer Webster-Cyriaque   +2 more
exaly   +3 more sources

Caveolin- and clathrin-independent entry of BKPyV into primary human proximal tubule epithelial cells

Virology, 2016
BK polyomavirus (BKPyV) is a human pathogen that causes polyomavirus-associated nephropathy and hemorrhagic cystitis in transplant patients. Gangliosides and caveolin proteins have previously been reported to be required for BKPyV infection in animal cell models.
Linbo Zhao, Michael J Imperiale
exaly   +3 more sources

BKPyV causing meningoencephalitis in HIV/AIDS patients in Argentina

Diagnostic Microbiology and Infectious Disease
Opportunistic infections in the central nervous system (CNS) by JCPyV/BKPyV in HIV/AIDS patients increase morbidity/mortality, especially in low-income countries. In Argentina, data regarding CNS-infection by polyomavirus in HIV/AIDS are scarce. We retrospectively evaluated BKPyV/JCPyV infections in cerebrospinal fluid (CSF) samples of HIV/AIDS ...
Maria C Frutos
exaly   +4 more sources

Human polyomavirus 9 as a potential threat in kidney transplant recipients; lessons from BKPyV

Transplant Immunology, 2023
As a therapeutic method, kidney transplantation significantly improved the life quality and prognosis of patients with the end-stage renal disease. Since a key element in stable kidney transplantation is continuous therapy with immunosuppressive agents, an inhibited immune response makes patients vulnerable to opportunistic viral and bacterial ...
Mohammad Hossein, Razizadeh, Alireza, Tabibzadeh   +1 more
openaire   +2 more sources

The detection of BKPyV genotypes II and IV after renal transplantation as a simple tool for risk assessment for PyVAN and transplant outcome already at early stages of BKPyV reactivation

Journal of Clinical Virology, 2019
After reactivation the BK-polyomavirus (BKPyV) associated nephropathy (PyVAN) is observed in 1-10% of renal transplant recipients, of which up to 80% undergo graft failure. BKPyV reactivation after renal transplantation was associated with donor-derived serotypes against which the recipient has no immunological protection.
Johannes Korth, Olympia Evdoxia Anastasiou, Jan Hinrich Bräsen, Alexandra Brinkhoff, Ulrich Lehmann, Andreas Kribben, Ulf Dittmer, Jens Verheyen, Benjamin Wilde, Sandra Ciesek, Oliver Witzke, Marek Widera   +11 more
openaire   +3 more sources