Results 71 to 80 of about 2,195 (192)

Tumor Immunotherapy and Microbiome: From Bench‐to‐Bedside Applications

MedComm, Volume 7, Issue 2, February 2026.
The microbiome is related to the efficacy of immunotherapy and can be utilized to predict the efficacy and adverse reactions of immunotherapy. Microbiome‐targeted intervention strategies can improve the efficacy of ICI, but necessitating more comprehensive exploration.
Anqi Lin, Minying Xiong, Aimin Jiang, Li Chen, Lihaoyun Huang, Kailai Li, Hank Z. H. Wong, Jian Zhang, Zaoqu Liu, Quan Cheng, Bufu Tang, Pengpeng Zhang, Peng Luo   +12 more
wiley   +1 more source

Polyomavirus JCPyV and Its Role in the Urinary Tract [PDF]

, 2022
Polyomaviruses are the smallest closed-circular supercoiled double-stranded viruses found in the human microbiota. The polyomavirus JC (JCPyV) is most commonly found within the urinary tract, and prior studies estimate that 20-80% of older adults carry ...
Mormando, Rita Lauren
core   +1 more source

Electrochemical Biosensor for Rapid Detection of Acute Rejection in Kidney Transplants

Advanced Healthcare Materials, Volume 15, Issue 1, 9 January 2026.
A low‐cost, rapid electrochemical immunosensor coated with a novel antifouling nanocomposite enables single‐step, dual‐biomarker profiling directly from unprocessed urine. Application in a clinical study shows accurate discrimination of acute rejection in kidney transplants from other acute kidney injuries via machine learning.
Rohit Gupta, Nikolaos Salaris, Ashish Kalkal, Fernando Yuen Chang, Maryam Javed, Azhar Ali Khan, Priya Mandal, Stavroula Balabani, Reza Motallebzadeh, Manish K. Tiwari   +9 more
wiley   +1 more source

JC Polyomavirus Infection of Primary Human Renal Epithelial Cells Is Controlled by a Type I IFN-Induced Response

mBio, 2016
The JC and BK human polyomaviruses (JCPyV and BKPyV, respectively) establish lifelong persistent infections in the kidney. In immunosuppressed individuals, JCPyV causes progressive multifocal leukoencephalopathy (PML), a fatal neurodegenerative disease ...
Benedetta Assetta, Marco De Cecco, Bethany O’Hara, Walter J. Atwood   +3 more
doaj   +1 more source

Organ Transplantation: Current Status, Challenges, and Future Prospects

MedComm, Volume 7, Issue 1, January 2026.
Organ transplantation success relies on precise modulation of the alloimmune response across distinct temporal phases of rejection. Hyperacute rejection results from preformed antibodies activating complement and causing thrombosis, while acute rejection involves T cell‐ and antibody‐mediated mechanisms that drive endothelial activation and ...
Xinqiang Li, Ruidong Ding, Jinzhen Cai
wiley   +1 more source

Roles of ATM and ATR-mediated DNA damage responses during lytic BK polyomavirus infection.

PLoS Pathogens, 2012
BK polyomavirus (BKPyV) is an emerging pathogen whose reactivation causes severe disease in transplant patients. Unfortunately, there is no specific anti-BKPyV treatment available, and host cell components that affect the infection outcome are not well ...
Mengxi Jiang, Linbo Zhao, Monica Gamez, Michael J Imperiale   +3 more
doaj   +1 more source

The Role of APOBEC3B in Cancer: Mechanisms, Clinical Challenges, and Therapeutic Opportunities

Human Mutation, Volume 2026, Issue 1, 2026.
Apolipoprotein B mRNA editing enzyme catalytic polypeptide‐like 3B (APOBEC3B, A3B) is a key cytidine deaminase that induces genomic instability and clonal evolution in diverse malignancies. Although A3B plays a key role in the onset and advancement of various cancers, a comprehensive model bridging its multifaceted mechanisms and clinical translation ...
Fengfeng Zhou, Weili Chen, Liqin Ruan, Run Shi   +3 more
wiley   +1 more source

Polyomavirus BK Genome Comparison Shows High Genetic Diversity in Kidney Transplant Recipients Three Months after Transplantation

Viruses, 2022
BK polyomavirus (BKPyV) is a human DNA virus generally divided into twelve subgroups based on the genetic diversity of Viral Protein 1 (VP1). BKPyV can cause polyomavirus-associated nephropathy (PVAN) after kidney transplantation.
Olga Mineeva-Sangwo, Joan Martí-Carreras, Evert Cleenders, Dirk Kuypers, Piet Maes, Graciela Andrei, Maarten Naesens, Robert Snoeck   +7 more
doaj   +1 more source

Importance of molecular diagnostic of viral infections in renal transplant recipients [PDF]

, 2019
Renal transplantation has for patients with end-stage renal disease significant survival and quality of life benefits, compared to dialysis. One of the most important complications after renal transplantation is the rejection of the kidney, also known as
Rurenga-Gard, Lilli
core   +2 more sources

Intravenous Immunoglobulin Administration Significantly Increases BKPyV Genotype-Specific Neutralizing Antibody Titers in Kidney Transplant Recipients [PDF]

Antimicrobial Agents and Chemotherapy, 2019
BK polyomavirus (BKPyV)-associated nephropathy (BKPyVAN) is one of the major causes of kidney graft dysfunction, and there are no BKPyV-specific antiviral therapies available. BKPyV neutralizing antibodies (NAbs) play key roles in protecting against BKPyV replication and represent a potential therapeutic or preventive strategy.
Aurélie, Velay, Morgane, Solis, Ilies, Benotmane, Pierre, Gantner, Eric, Soulier, Bruno, Moulin, Sophie, Caillard, Samira, Fafi-Kremer   +7 more
openaire   +2 more sources