Comparative genomic study of bla KPC-2-carrying multidrug-resistant Klebsiella pneumoniae in the United Arab Emirates [PDF]
Scientific ReportsWe performed whole-genome sequencing of three multidrug-resistant KPC-producing Klebsiella pneumoniae isolates recovered from patients in a tertiary-care hospital in Abu Dhabi, UAE, and conducted a comparative genomic analysis with previously reported ...
Akela Ghazawi +9 more
doaj +3 more sources
Genomic characterization of a blaKPC-2–producing IncM2 plasmid harboring transposon ΔTn6296 in Klebsiella michiganensis [PDF]
Frontiers in Cellular and Infection MicrobiologyKlebsiella michiganensis is an emerging hospital-acquired bacterial pathogen, particularly strains harboring plasmid-mediated carbapenemase genes.
Jian-Mei Song +12 more
exaly +4 more sources
Journal of Global Antimicrobial Resistance, 2022 : Objective: The main objectives were to describe two blaKPC-2 plasmids recovered from Pseudomonas aeruginosa isolates belonging to the ST654 and ST235 high-risk clones, and to compare with complete sequences of blaKPC-2 harbouring plasmids available in
Daniela Cejas +8 more
doaj +5 more sources
An update of the evolving epidemic of blaKPC-2-carrying Klebsiella pneumoniae in Greece (2009-10) [PDF]
Journal of Antimicrobial Chemotherapy, 2011 To follow the epidemic of KPC-2-producing Klebsiella pneumoniae in Greece.KPC-2-producing isolates (n = 378) were collected during January 2009-April 2010 in 40 Greek hospitals. bla(KPC) and bla(VIM) were detected by PCR. Carbapenemase production was confirmed by spectrophotometry.
Panagiota Giakkoupi +2 more
exaly +4 more sources
Genomic features and fitness cost of co-existence of blaKPC-2 and blaVIM-2 plasmids in ICU-derived pan-drug resistant Pseudomonas aeruginosa [PDF]
Frontiers in Cellular and Infection MicrobiologyBackgroudThe emergence of carbapenem-resistant Pseudomonas aeruginosa (CRPA) co-producing KPC-2 and VIM-2 has increased the healthcare threats.ResultsIn this study, a CRPA strain 18102011, was isolated from the bile of a burn patient in ICU of China. Its
Lin Zheng +10 more
doaj +2 more sources
Frontiers in Microbiology, 2021 The emergence of hypervirulent carbapenem-resistant Klebsiella pneumoniae (hv-CRKP) was regarded as an emerging threat in clinical settings. Here, we investigated the prevalence of CRKP strains among inpatients in a new hospital over 1 year since its ...
Shangshang Qin, Ruichao Li
exaly +3 more sources
Evolution of ceftazidime–avibactam resistance driven by mutations in double-copy blaKPC-2 to blaKPC-189 during treatment of ST11 carbapenem-resistant Klebsiella pneumoniae [PDF]
mSystemsKlebsiella pneumoniae carbapenemase (KPC) variants can contribute to resistance to ceftazidime–avibactam (CZA) in Klebsiella pneumoniae (KP). However, two-copy KPC variant-mediated resistance to CZA has rarely been reported to date.
Xiaofan Zhang +11 more
doaj +2 more sources
Phenotypic and genomic characterization of ST11-K1 CR-hvKP with highly homologous blaKPC-2-bearing plasmids in China [PDF]
mSystemsCarbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) strains present a significant global public health threat due to their high mortality rates.
Yu-Ling Han +9 more
doaj +2 more sources
Worldwide Diversity of Klebsiella pneumoniae That Produce β-Lactamase blaKPC-2 Gene
Emerging Infectious Diseases, 2010 Klebsiella pneumoniae isolates that produce carbapenemases (KPCs) are rapidly disseminating worldwide. To determine their genetic background, we investigated 16 blaKPC-2-harboring K. pneumoniae isolates from 5 countries.
Gaëlle Cuzon +9 more
doaj +3 more sources
Double blaKPC-2 copies quadrupled minimum inhibitory concentration of ceftazidime–avibactam in hospital-derived Klebsiella pneumoniae [PDF]
Microbiology SpectrumTo illustrate the genomic and drug resistance traits of the Klebsiella pneumoniae Kpn_XM9, which harbors a transposon (Tn) As1 and was barely susceptible to ceftazidime–avibactam (CZA). Whole-genome sequencing, gene deletion, antimicrobial susceptibility,
Dakang Hu +7 more
doaj +2 more sources