Results 41 to 50 of about 7,824 (162)

Emergence of multidrug-resistant ST11 blaKPC-2 producing Klebsiella pneumoniae coharboring blaCTX-M and blaSHV in Pakistan

The Journal of Infection in Developing Countries, 2023
Introduction: Carbapenemases are primarily responsible for the intensified spread of multidrug-resistant (MDR) K. pneumoniae by virtue of antibiotics overuse. Therefore, frequent investigation of high-risk clones especially from developing world is crucial to curtail global spread. Methodology: In this observational study, 107 K.
Aamir Jamal Gondal, Sidrah Saleem, Nakhshab Choudhry, Fridoon Jawad Ahmad, Hina Bukhari, Nighat Yasmin, Shah Jahan   +6 more
openaire   +3 more sources

In vitro mimicry of in vivo KPC mutations by ceftazidime-avibactam: phenotypes, mechanisms, genetic structure and kinetics of enzymatic hydrolysis

Emerging Microbes and Infections
Ceftazidime-avibactam (CZA) is employed for the treatment of infections caused by Klebsiella pneumoniae carbapenemase-producing K. pneumoniae (KPC-KP). Resistance to CZA is frequently linked to point mutations in the blaKPC.
Siquan Shen, Chengkang Tang, Weiwei Yang, Li Ding, Renru Han, Qingyu Shi, Yan Guo, Dandan Yin, Fupin Hu   +8 more
doaj   +1 more source

Design of Rapid Detection System for Five Major Carbapenemase Families (blaKPC, blaNDM, blaVIM, blaIMP and blaOXA-48-Like) by Colorimetric Loop-Mediated Isothermal Amplification

Infection and Drug Resistance, 2021
Wenjuan Feng,* Siqiang Niu,* Yanbin Chang, Xiaojiong Jia, Shifeng Huang, Ping Yang Department of Clinical Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China*These authors ...
Feng W, Niu S, Chang Y, Jia X, Huang S, Yang P   +5 more
doaj  

Analyses of a Ceftazidime-Avibactam-Resistant Citrobacter freundii Isolate Carrying bla_KPC-2 Reveals a Heterogenous Population and Reversible Genotype

mSphere, 2018
A blaKPC-2-carrying Citrobacter freundii isolate developed ceftazidime-avibactam resistance during treatment with this agent. The initial and follow-up isolates exhibited ceftazidime-avibactam MICs of 4 and 64 µg/ml, respectively. Overexpression of AcrAB-
Mariana Castanheira, S. J. Ryan Arends, Andrew P. Davis, Leah N. Woosley, Amira A. Bhalodi, Shawn H. MacVane   +5 more
doaj   +1 more source

ANÁLISE DA INFLUÊNCIA DO NÚMERO DE CÓPIAS NA EXPRESSÃO DO GENE BLAKPC EM ISOLADOS CLÍNICOS DE MORGANELLA MORGANII E PROVIDENCIA STUARTII

Brazilian Journal of Infectious Diseases, 2023
Introdução/Objetivo: Organismos produtores de Klebsiella pneumoniae carbapenemase (KPC) são desafiadores em termos terapêuticos e diagnósticos, pois comumente apresentam resistência a todos os beta-lactâmicos.
Michelly Maria Pereira e Oliveira, Crisvania Pedrosados Santos Nascimento, Paula Mariana Salgueiro de Souza, Márcia Maria Camargo de Morais, Anna Carolina Soares Almeida   +4 more
doaj   +1 more source

Novel small IncX3 plasmid carrying the blaKPC-2 gene in high-risk Klebsiella pneumoniae ST11/CG258

Diagnostic Microbiology and Infectious Disease, 2020
This study used whole-genome sequencing (WGS) and PFGE to analysis KPC-2-producing Klebsiella pneumoniae strains from clinical specimens collected in Brazilian hospitals. The study identifies the emergence of a novel small IncX3 plasmid (pKPB11), 12,757-bp in length, in a high-risk K.
Bruna, Fuga, Melina Lorraine, Ferreira, Louise Teixeira, Cerdeira, Paola Amaral, de Campos, Vinícius Lopes, Dias, Iara, Rossi, Luiz Gustavo, Machado, Nilton, Lincopan, Paulo Pinto, Gontijo-Filho, Rosineide Marques, Ribas   +9 more
openaire   +2 more sources

Characterization of genetic context of blaKPC in Pseudomonas aeruginosa

Frontiers in Microbiology
The rising prevalence of blaKPC-harboring Pseudomonas aeruginosa (KPC-PA) is a significant threat to public health. In the study, we identified a carbapenem-resistant P. aeruginosa (CRPA; PAE3) from a patient with pneumonia infection.
Mingxiao Chen, Tingting Deng, Xiaobin Li, Runcheng Zhou, Zhangshu Gao, Die Zhou, Jianqiang Zhu, Jingjie Li, Xin Chen, Minling Wang, Rui Zhang, Qiang Zhou   +11 more
doaj   +1 more source

Evaluation of FilmArray Multiplex PCR Test Results in Bloodstream Infections in Oncological Patients

Journal of Clinical Laboratory Analysis, EarlyView.
In this study conducted at an oncology hospital, BCID2 panel results for the rapid identification of microorganisms and resistance genes in positive blood culture samples were compared with conventional culture methods. The BCID2 panel provided faster results and showed a high correlation with traditional methods.
İpek Mumcuoğlu, Sevgi Şahin, Esra Tavukcu, Neşe İnan, Ayşe Semra Güreser, Serap Süzük Yıldız, Tuba Dal   +6 more
wiley   +1 more source

Genomic Analysis of KPC-2-Producing Klebsiella pneumoniae ST11 Isolates at the Respiratory Department of a Tertiary Care Hospital in Beijing, China

Frontiers in Microbiology, 2022
BackgroundCarbapenem-resistant Klebsiella pneumoniae (CRKP) is an important pathogen causing hospital-associated outbreaks worldwide. The spread of K. pneumoniae carbapenemase-2 (KPC-2)-producing CRKP is primarily associated with sequence type (ST) 11 ...
Ling Guo, Lifeng Wang, Qiang Zhao, Liyan Ye, Kun Ye, Yanning Ma, Dingxia Shen, Jiyong Yang   +7 more
doaj   +1 more source

Genomic Insights Into Carbapenem‐Resistant Klebsiella pneumoniae in Pediatric Bloodstream Infections in Zhejiang, China (2019–2024)

Journal of Clinical Laboratory Analysis, EarlyView.
The primary mechanism of carbapenem resistance identified in pediatric CRKP‐BSI strains was the production of Class B metalloenzymes. We report, for the first time, an outbreak of bloodstream infections in a neonatal ward caused by the dissemination of NDM‐1‐producing ST25 K. pneumoniae.
Mingming Zhou, Xiucai Zhang, Zhenjie Chen, Chao Fang, Shixing Liu, Jintao Xia, Yining Zhao, Chenmei Zhang, Hongqiang Shen   +8 more
wiley   +1 more source