Results 51 to 60 of about 7,824 (162)

Suboptimal ceftazidime-avibactam exposure drives sequential blaKPC mutations and intra-host coexistence of Klebsiella pneumoniae harboring distinct variants leading to persistent infection

Microbiology Spectrum
KPC-producing Klebsiella pneumoniae infections are a rising global health threat. The factors driving blaKPC mutations during treatment and their contribution to infection persistence remain unclear.
Feng Yang, Weiwei Yang, Jinghao Zhang, Chengkang Tang, Li Ding, Siquan Shen, Yanhao Zhou, Hongyu Zhao, Jiaojiao Zhou, Fupin Hu   +9 more
doaj   +1 more source

Whole-genome sequencing of carbapenem-resistant Enterobacterales isolates in southeast Louisiana reveals persistent genetic clusters spanning multiple locations

Journal of Infection and Public Health, 2023
Background: We investigated 51 g-negative carbapenem-resistant Enterobacterales (CRE) isolates collected from 22 patients over a five-year period from six health care institutions in the Ochsner Health network in southeast Louisiana.
Rebecca Rose, Amy Feehan, Benjamin N. Lain, Deborah Ashcraft, David J. Nolan, Leonor Velez-Climent, Christopher Huston, Tessa LaFleur, Simon Rosenthal, Gary B. Fogel, Lucio Miele, George Pankey, Julia Garcia-Diaz, Susanna L. Lamers   +13 more
doaj   +1 more source

Promoter characterization and expression of the blaKPC-2 gene in Escherichia coli, Pseudomonas aeruginosa and Acinetobacter baumannii [PDF]

Journal of Antimicrobial Chemotherapy, 2017
KPC-producing pathogens exhibit variable carbapenem susceptibility levels, which is probably the result of the genetic environment of the bla KPC genes. Here we determined the transcriptional start sites (TSSs) and the expression of the bla KPC-2 gene in various genetic contexts and in different hosts ( Escherichia coli , Pseudomonas aeruginosa and ...
Delphine, Girlich, Rémy A, Bonnin, Agnes, Jousset, Thierry, Naas   +3 more
openaire   +2 more sources

Pathogenicity and Antimicrobial‐Resistance Profiles of Escherichia coli Isolated From Faeces of Tibetan Pigs Reared Under Intensive Conditions

Veterinary Medicine and Science, Volume 12, Issue 3, May 2026.
Tibetan pig farms host diverse Escherichia coli strains that resist multiple antibiotics and carry important disease genes, such as astA. These traits jump easily between bacterial groups, marking intensive pig production as a key reservoir and signalling the need for integrated animal–human surveillance and more careful antibiotic use.
Runbo Luo, Lihong Zhang, Kexin Li, Yanan Zhong, Peng Shang, Suolang Sizhu, Md. F. Kulyar, Ruibing Cao   +7 more
wiley   +1 more source

Enterobacter cloacae harbouring blaKPC-2 and qnrB-1 isolated from a cystic fibrosis patient: a case report

New Microbes and New Infections, 2018
We describe the first detection of a KPC-2- and QnrB-producing Enterobacter cloacae from a patient with cystic fibrosis. The blaKPC-2 and qnrB-1 genes were located in a 79.8-kb plasmid.
D.P. Alves, A.P.D'A Carvalho-Assef, O.C. Conceição-Neto, C.A.M. Aires, R.M. Albano, T.W. Folescu, S.C.S. Ornelas, R.S. Leão, E.A. Marques   +8 more
doaj   +1 more source

Emergence and Genomic Characterization of a Hypervirulent Klebsiella pneumoniae Isolate From a New Clone in Brazil

Microbiology and Immunology, Volume 70, Issue 5, Page 261-267, May 2026.
ABSTRACT Hypervirulent Klebsiella pneumoniae (hvKp) has emerged globally as a major public health concern, often associated with severe community‐acquired and healthcare‐associated human infections. Despite alerts from PAHO/WHO on convergent hvKp strains with multidrug resistance in Latin America, comprehensive data from Brazil, the region's largest ...
Carlos Henrique Camargo, Ana Beatriz Nascimento Costa, Amanda Yaeko Yamada, Daniel de Sena Miranda, Pedro Smith Pereira Ferraro, Andreia Rodrigues de Souza, Amanda Maria de Jesus Bertani, Karoline Rodrigues Campos, Marlon Benedito Nascimento Santos, Rafaela Mastrangelo Rissetti, Carolina Lechinski de Paula, Patrik Júnior de Lima Paz, Maria Solange Duarte Soares, Christiane Salvador, Giovanna de Pinho Pieri, Jorge Siguemassa Higa, Daniela dos Santos Souza, Márcio Garcia Ribeiro, Claudio Tavares Sacchi, Monique Ribeiro Tiba‐Casas, Geraldine Madalosso, Denise Brandao de Assis   +21 more
wiley   +1 more source

Characteristics of rare ST463 carbapenem-resistant Pseudomonas aeruginosa clinical isolates from blood

Journal of Global Antimicrobial Resistance, 2023
Objectives: This study aimed to elucidate resistance to carbapenems and fluoroquinolones, the transmission mechanism of blaKPC-2, and the virulence characteristics of a Pseudomonas aeruginosa strain (TL3773) isolated in East China. Methods: The virulence
Xiaodong Zhang, Miran Tang, Ye Xu, Mengxin Xu, Changrui Qian, Xiangkuo Zheng, Tieli Zhou, Qing Wu   +7 more
doaj   +1 more source

Highly Resolved Community Sewage Metagenomics Unveiling Landscape and Transmission Patterns of Antibiotic Resistome in Hong Kong Populations

Advanced Science, Volume 13, Issue 20, 9 April 2026.
A large‐scale, high‐resolution antimicrobial resistance (AMR) surveillance in Hong Kong community sewage combining short‐ and long‐read sequencing. The resistome profile is comprehensively characterized, and this upstream sampling strategy demonstrated superiority in reflecting the human gut resistome.
Jiahui Ding, Mengying Wang, Xiaoqing Xu, Dou Wang, Xi Chen, Shuxian Li, Xiawan Zheng, You Che, Yu Deng, Tommy T. Y. Lam, Liguan Li, Tong Zhang   +11 more
wiley   +1 more source

Wide Dissemination of Pseudomonas aeruginosa Producing β-Lactamase blaKPC-2 Gene in Colombia▿ [PDF]

Antimicrobial Agents and Chemotherapy, 2011
ABSTRACT Ten bla KPC-2 -harboring Pseudomonas aeruginosa isolates from hospitals located in five different Colombian cities have been characterized. Isolates were multidrug resistant, belonged to five different pulsotypes, and possessed naturally chromosome-encoded
Cuzon, G., Naas, T., Villegas, M.-V., Correa, A., Quinn, J. P., Nordmann, P.   +5 more
openaire   +3 more sources

Antimicrobial resistance and phylogenetic lineages of KPC-2-producing blood-borne Klebsiella pneumoniae subsp. pneumoniae from Kolkata, India during 2015–2024: Emergence of Klebsiella pneumoniae subsp. pneumoniae with blaKPC-2, blaNDM, and blaOXA-48-like triple carbapenemases

Microbiology Spectrum
In view of insufficient data on the epidemiology and genomics of blaKPC-2 producing Klebsiella pneumoniae subsp. pneumoniae (KPC-2 Kpn) from India, this study, first of its kind, was conducted to characterize blood-borne KPC-2 Kpn isolates according to ...
Gourab Halder, Bhaskar Narayan Chaudhuri, Balaji Veeraraghavan, Priyanka Denny, Paulami Dutta, Mandira Chakraborty, Ujjwayini Ray Khan, Shelley Sharma Ganguly, Subhranshu Mandal, Yesha Parasmani Upadhyaya, Bedobroto Biswas, Arindam Chakraborty, Sourav Maiti, Himadri Mondal, Saikat Pal, Shanta Dutta   +15 more
doaj   +1 more source