Results 31 to 40 of about 7,824 (162)

Replicative transposition contributes to the evolution and dissemination of KPC-2-producing plasmid in Enterobacterales

Emerging Microbes and Infections, 2022
Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacterales are prevalent worldwide and pose an alarming threat to public health. The incidence and transmission of blaKPC-2 gene via horizontal gene transfer (e.g.
Yu Tang, Gang Li, Pinghua Shen, Ying Zhang, Xiaofei Jiang   +4 more
doaj   +1 more source

A Recombinase Aided Amplification Assay for Rapid Detection of the Klebsiella pneumoniae Carbapenemase Gene and Its Characteristics in Klebsiella pneumoniae

Frontiers in Cellular and Infection Microbiology, 2021
Klebsiella pneumoniae carbapenemase genes (blaKPC) play an important role in carbapenem-resistant Enterobacteriaceae in China. A rapid detection method for blaKPC genes and investigations into the molecular characteristics of blaKPC positive Klebsiella ...
Weiwei Zhang, Weiwei Zhang, Yanling Feng, Hanqing Zhao, Chao Yan, Junxia Feng, Lin Gan, Jinghua Cui, Shiyu Liu, Rui Zhang, Shuheng Du, Nannan Li, Wenjian Xu, Juqiang Han, Rongkuan Li, Guanhua Xue, Jing Yuan   +16 more
doaj   +1 more source

Coexistence of three blaKPC-2 genes on an IncF/IncR plasmid in ST11 Klebsiella pneumoniae [PDF]

Journal of Global Antimicrobial Resistance, 2019
Here we report the finding of three copies of the blaKPC-2 gene on a plasmid in ST11 Klebsiella pneumoniae.Carbapenem-resistant K. pneumoniae clinical strain WCHKP2 was subjected to whole-genome sequencing (WGS) using both a short-read Illumina HiSeq X10 platform and long-read MinION sequencer. Hybrid assembly was performed using Unicycler, and contigs
Yu, Feng, Lu, Liu, Alan, McNally, Zhiyong, Zong   +3 more
openaire   +2 more sources

Emergence of colistin resistance in Klebsiella pneumoniae ST15 disseminating blaKPC-2 in a novel genetic platform

Journal of Global Antimicrobial Resistance, 2022
Isolation of colistin- and carbapenem-resistant Klebsiella pneumoniae (CCR-Kp) is increasing in hospital settings worldwide, which is related to increased morbidity, mortality and healthcare costs. The aim of this work was to perform whole-genome sequencing (WGS), genomic and phylogenetic analysis, and conjugation assays of an extensively drug ...
Verónica E. Álvarez, Mariana G. Massó, Gabriela D’amico González, Anahí S. Gambino, Camila A. Knecht, Bárbara Prack Mc Cormick, Carolina Leguina, María Piekar, Tomás Poklepovich, Josefina Campos, Sonia Arduino, Daniela Centrón, María P. Quiroga   +12 more
openaire   +4 more sources

Co-Carriage of blaKPC-2 and blaNDM-1 in Clinical Isolates of Pseudomonas aeruginosa Associated with Hospital Infections from India. [PDF]

PLoS ONE, 2015
Global spread of KPC poses to be a serious threat complicating treatment options in hospital settings. The present study investigates the genetic environment of blaKPC-2 among clinical isolates of Pseudomonas aeruginosa from a tertiary referral hospital ...
Deepjyoti Paul, Debadatta Dhar Chanda, Anand Prakash Maurya, Shweta Mishra, Atanu Chakravarty, Gauri Dutt Sharma, Amitabha Bhattacharjee   +6 more
doaj   +1 more source

Outbreak of IncX8 Plasmid–Mediated KPC-3–Producing Enterobacterales Infection, China

Emerging Infectious Diseases, 2022
Carbapenem-resistant Enterobacterales (CRE) infection is highly endemic in China; Klebsiella pneumoniae carbapenemase (KPC) 2–producing CRE is the most common, whereas KPC-3–producing CRE is rare.
Lan Chen, Wenxiu Ai, Ying Zhou, Chunyang Wu, Yinjuan Guo, Xiaocui Wu, Bingjie Wang, Lulin Rao, Yanlei Xu, Jiao Zhang, Liang Chen, Fangyou Yu   +11 more
doaj   +1 more source

Characterisation of blaNDM-5 and blaKPC-2 co-occurrence in K64-ST11 carbapenem-resistant Klebsiella pneumoniae

Journal of Global Antimicrobial Resistance, 2021
The aim of this study was to characterise the co-occurrence of blaKPC and blaNDM in a K64-ST11 carbapenem-resistant Klebsiella pneumoniae strain.Antimicrobial susceptibility was determined by the disk diffusion method. Whole-genome sequencing was performed using Illumina MiSeq and PacBio II sequencers.
Renjing Hu, Qin Li, Feiyang Zhang, Manlin Ding, Jun Liu, Yingshun Zhou   +5 more
openaire   +3 more sources

Emergence of Ceftazidime- and Avibactam-Resistant Klebsiella pneumoniae Carbapenemase-Producing Pseudomonas aeruginosa in China

mSystems, 2021
Klebsiella pneumoniae carbapenemase (KPC)-producing Pseudomonas aeruginosa (KPC-PA) has been reported sporadically. However, epidemiological and antimicrobial susceptibility data specific for KPC-PA are lacking.
Yiwei Zhu, Jie Chen, Han Shen, Zhongju Chen, Qi-wen Yang, Jin Zhu, Xi Li, Qing Yang, Feng Zhao, Jingshu Ji, Heng Cai, Yue Li, Linghong Zhang, Sebastian Leptihn, Xiaoting Hua, Yunsong Yu   +15 more
doaj   +1 more source

Genomic analysis of an extensively drug-resistant Pseudomonas aeruginosa ST312 harbouring IncU plasmid-mediated blaKPC-2 isolated from ascitic fluid

Journal of Global Antimicrobial Resistance, 2021
: Objectives: The Klebsiella pneumoniae carbapenemase (KPC) is disseminated worldwide mostly by plasmids. However, in Pseudomonas aeruginosa chromosomal mutations are more frequently responsible for resistance to carbapenems than the acquisition of ...
Daniela Cristina Tartari, Caetana Paes Zamparette, Graciele Martini, Sandra Christakis, Luiz Henrique Costa, Alessandro Conrado de Oliveira Silveira, Thaís Cristine Marques Sincero   +6 more
doaj   +1 more source

First report of blaVEB-3 and blaKPC-2 coexistence with a novel blaKPC-2 transposon in Klebsiella michiganensis

Infection, Genetics and Evolution
Klebsiella michiganensis, an emerging opportunistic pathogen, poses public health risks due to its increasing multidrug resistance (MDR), especially to carbapenems.A 46-year-old man with pulmonary fibrosis was hospitalized in Guangzhou, China, for worsening pneumonia. A multidrug-resistant K.
Yuxia, Zhong, Peibo, Yuan, Liting, Dai, Ling, Yang, Zhenbo, Xu, Dingqiang, Chen   +5 more
openaire   +2 more sources