Results 41 to 50 of about 1,862,609 (237)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

The Effects of Mild Traumatic Brain Injury on Cognitive-Motor Integration for Skilled Performance

Frontiers in Neurology, 2020
Adults exposed to blast and blunt impact often experience mild traumatic brain injury, affecting neural functions related to sensory, cognitive, and motor function.
Lauren E. Sergio, Lauren E. Sergio, Diana J. Gorbet, Diana J. Gorbet, Meaghan S. Adams, Meaghan S. Adams, Meaghan S. Adams, Danielle M. Dobney, Danielle M. Dobney   +8 more
doaj   +1 more source

Modelling of the low-impulse blast behaviour of fibre–metal laminates based on different aluminium alloys [PDF]

, 2013
A parametric study has been undertaken in order to investigate the influence of the properties of the aluminium alloy on the blast response of fibre–metal laminates (FMLs).
Guan, Zhongwei, Vo, Thuc, Schleyer, Graham, Cantwell, Wesley   +3 more
core   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Effects of low-level blast exposure on the nervous system: Is there really a controversy?

Frontiers in Neurology, 2014
High-pressure blast waves can cause extensive CNS injury in humans. However, in combat settings such as Iraq and Afghanistan, lower level exposures associated with mild TBI (mTBI) or subclinical exposure have been much more common. Yet controversy exists
Gregory A Elder, James Radford Stone, Stephen Thomas Ahlers   +2 more
doaj   +1 more source

DNA Methylation Patterns of Chronic Explosive Breaching in U.S. Military Warfighters

Frontiers in Neurology, 2020
Background: Injuries from exposure to explosions rose dramatically during the Iraq and Afghanistan wars, which motivated investigation of blast-related neurotrauma.
Zhaoyu Wang, Caroline M. Wilson, Caroline M. Wilson, Yongchao Ge, Jeffrey Nemes, Christina LaValle, Angela Boutté, Walter Carr, Walter Carr, Gary Kamimori, Fatemeh Haghighi, Fatemeh Haghighi   +11 more
doaj   +1 more source

Repetitive Blast Exposure Produces White Matter Axon Damage without Subsequent Myelin Remodeling: In Vivo Analysis of Brain Injury Using Fluorescent Reporter Mice

Neurotrauma Reports, 2021
The potential effects of blast exposure on the brain health of military personnel have raised concerns and led to increased surveillance of blast exposures. Neuroimaging studies have reported white matter abnormalities in brains of service members with a
Donald V. Bradshaw, Yeonho Kim, Amanda Fu, Christina M. Marion, Kryslaine L. Radomski, Joseph T. McCabe, Regina C. Armstrong   +6 more
doaj   +1 more source

Ngland: Exposure Festival [PDF]

, 2020
This short film is a companion work to A Profound Difference and presents a visual meditation on the political events and social environment that arose due to the UK Referendum on EU Membership.
Harris, Philip
core  

Close blast exposure and posttraumatic stress disorder [PDF]

, 2021
The conflicts in Iraq and Afghanistan have continued to provide unique challenges for military personnel and researchers alike. Of note is the increase in literature linking posttraumatic stress disorder with the exposure of service personnel to ...
NC DOCKS at Western Carolina University, Barton, Patrick C.   +1 more
core  

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source