Results 51 to 60 of about 82,637 (249)

Repeated Low Intensity Blast Exposure Is Associated with Damaged Endothelial Glycocalyx and Downstream Behavioral Deficits

Frontiers in Behavioral Neuroscience, 2017
Current clinical research into mild traumatic brain injury (mTBI) has focused on white matter changes as identified by advanced MRI based imaging techniques. However, perivascular tau accumulation in the brains of individuals diagnosed with mTBI suggests
Aaron A. Hall, Mirian I. Mendoza, Hanbing Zhou, Michael Shaughness, Richard M. McCarron, Stephen T. Ahlers   +5 more
doaj   +1 more source

The Effects of Mild Traumatic Brain Injury on Cognitive-Motor Integration for Skilled Performance

Frontiers in Neurology, 2020
Adults exposed to blast and blunt impact often experience mild traumatic brain injury, affecting neural functions related to sensory, cognitive, and motor function.
Lauren E. Sergio, Lauren E. Sergio, Diana J. Gorbet, Diana J. Gorbet, Meaghan S. Adams, Meaghan S. Adams, Meaghan S. Adams, Danielle M. Dobney, Danielle M. Dobney   +8 more
doaj   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Blast Overpressure-Induced Neuroinflammation and Axonal Injury in the Spinal Cord of Ferrets

Brain Sciences
Background: Blast-induced spinal cord injuries (bSCI) account for 75% of all combat-related spinal trauma and are associated with long-term functional impairments.
Gaurav Phuyal, Chetan Y. Pundkar, Manoj Y. Govindarajulu, Rex Jeya Rajkumar Samdavid Thanapaul, Aymen Al-Lami, Ashwathi Menon, Joseph B. Long, Peethambaran Arun   +7 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Vascular and inflammatory factors in the pathophysiology of blast-induced brain injury

Frontiers in Neurology, 2015
Blast-related traumatic brain injury (TBI) has received much recent attention because of its frequency in the conflicts in Iraq and Afghanistan. This renewed interest has led to a rapid expansion of clinical and animal studies related to blast. In humans,
Gregory A Elder, Miguel A Gama Sosa, Rita eDe Gasperi, James Radford Stone, Dara eDickstein, Fatemeh eHaghighi, Patrick R Hof, Stephen T Ahlers   +7 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Blast–related disinhibition and risk seeking in mice and combat Veterans: Potential role for dysfunctional phasic dopamine release

Neurobiology of Disease, 2017
Mild traumatic brain injury (mTBI) caused by exposure to high explosives has been called the “signature injury” of the wars in Iraq and Afghanistan. There is a wide array of chronic neurological and behavioral symptoms associated with blast-induced mTBI.
A.G. Schindler, J.S. Meabon, K.F. Pagulayan, R.C. Hendrickson, K.D. Meeker, M. Cline, G. Li, C. Sikkema, C.W. Wilkinson, D.P. Perl, M.R. Raskind, E.R. Peskind, J.J. Clark, D.G. Cook   +13 more
doaj   +1 more source

Estimating Blast Exposures From The 2020 Beirut Explosion And Examining Correlation With Blast Injuries [PDF]

On 4th August 2020, approximately 2750 tonnes of Ammonium Nitrate stored in the port of Beirut ignited, causing a huge explosion that damaged large parts of the city, causing more than 200 deaths and over 7,000 injuries. Injured victims’ locations at the time of the explosion were previously unreported and unknown due to improper documentation. Without
Denny, Jack, Batchelor, James, Al-Hajj, Samar   +2 more
openaire   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source