Results 71 to 80 of about 222,866 (288)

Cosmic Ray Acceleration at the Forward Shock in Tycho's Supernova Remnant: Evidence from Chandra X-ray Observations [PDF]

, 2005
We present evidence for cosmic ray acceleration at the forward shock in Tycho's supernova remnant (SNR) from three X-ray observables: (1) the proximity of the contact discontinuity to the forward shock, or blast wave, (2) the morphology of the emission ...
Cara Rakowski, Carles Badenes, Christopher F. McKee, David Moffett, Ellison D. C., Estela Reynoso, Fink H. H., Green D. A., Jessica S. Warren, John P. Hughes, Parviz Ghavamian, Patrick Slane, Paul P. Plucinsky, Velazquez P. F.   +13 more
core   +3 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Repeated Low Intensity Blast Exposure Is Associated with Damaged Endothelial Glycocalyx and Downstream Behavioral Deficits

Frontiers in Behavioral Neuroscience, 2017
Current clinical research into mild traumatic brain injury (mTBI) has focused on white matter changes as identified by advanced MRI based imaging techniques. However, perivascular tau accumulation in the brains of individuals diagnosed with mTBI suggests
Aaron A. Hall, Mirian I. Mendoza, Hanbing Zhou, Michael Shaughness, Richard M. McCarron, Stephen T. Ahlers   +5 more
doaj   +1 more source

Computational and in vitro studies of blast-induced blood-brain barrier disruption

, 2015
There is growing concern that blast-exposed individuals are at risk of developing neurological disorders later in life. Therefore, it is important to understand the dynamic properties of blast forces on brain cells, including the endothelial cells that ...
Banks, William A., Cook, David G., Del Razo, Mauricio J., Huber, B. Russell, Leveque, Randall J., Meabon, James S., Morofuji, Yoichi, Mourad, Pierre D., Peskind, Elaine R.   +8 more
core   +1 more source

Dense, Fe-rich Ejecta in Supernova Remnants DEM L238 and DEM L249: A New Class of Type Ia Supernova? [PDF]

, 2006
We present observations of two LMC supernova remnants (SNRs), DEM L238 and DEM L249, with the Chandra and XMM-Newton X-ray satellites. Bright central emission, surrounded by a faint shell, is present in both remnants. The central emission has an entirely
Battinelli P., Blair W. P., Caloi V., Fukui Y., Itoh H., Kazimierz J. Borkowski, Kinugasa K., Mannucci F., Mizuno N., Nishiuchi M., Sean P. Hendrick, Stephen P. Reynolds, Tsujimoto T.   +12 more
core   +4 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Red Blood Cell Response to Blast Levels of Force Impartations Into Freely Moveable Fluid Surfaces Inside a Closed Container

Frontiers in Physics, 2018
Background: Blast waves have plagued mankind for centuries, yet their interaction with blood has been largely overlooked. Recent studies of ways to mitigate traumatic brain injury (TBI) in sport have utilized slosh-reducing techniques with varying ...
David Smith, Robert Franco, Christopher A. DiCesare, Daniel K. Schneider, Daniel K. Schneider, Chuck McGill, Quinton D. Smith, Quinton D. Smith, Gregory D. Myer, Gregory D. Myer, Gregory D. Myer   +10 more
doaj   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Environmental Impact on the Southeast Limb of the Cygnus Loop

, 2004
We analyze observations from the Chandra X-ray Observatory of the southeast knot of the Cygnus Loop supernova remnant. In this region, the blast wave propagates through an inhomogeneous environment.
James R. Graham, N. A. Levenson, Spitzer L., Jr.   +2 more
core   +1 more source