Results 61 to 70 of about 222,866 (288)

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Respiratory symptoms and pulmonary physiologic outcomes among post-9/11 veterans with blast exposure

Frontiers in Public Health
IntroductionAmong post-9/11 veterans reporting blast exposure from the Veterans Affairs (VA) Toxic Embedded Fragment (TEF) registry, respiratory symptoms are common.
Danielle R. Glick, Danielle R. Glick, Joanna M. Gaitens, Joanna M. Gaitens, Clayton H. Brown, Clayton H. Brown, Melissa A. McDiarmid, Melissa A. McDiarmid, Maxwell Reback, Katherine H. Chin, Kerri L. Cavanaugh, William E. Lawson, Peruvemba Sriram, Lisa Beck, John Duch, Samuel M. Aguayo, Paska Permana, Stella E. Hines, Stella E. Hines   +18 more
doaj   +1 more source

A Thoracic Mechanism of Mild Traumatic Brain Injury Due to Blast Pressure Waves [PDF]

, 2008
The mechanisms by which blast pressure waves cause mild to moderate traumatic brain injury (mTBI) are an open question. Possibilities include acceleration of the head, direct passage of the blast wave via the cranium, and propagation of the blast wave to
Amy Courtney, Michael Courtney
core   +1 more source

GPS based vehicle tracking system [PDF]

, 2021
The research is about creating a system for tracking vehicle. Objective of the research is to design and develop a GPS based Vehicle Tracking System in order to display location of vehicle on Google Maps.
Mohd Nazri, Mohd Fiqri, Zohari, Mohd Hakimi   +1 more
core  

Blast Wave Exposure to the Extremities Causes Endothelial Activation and Damage [PDF]

Shock, 2015
Extremity injury is a significant burden to those injured in explosive incidents and local ischaemia can result in poor functionality in salvaged limbs. This study examined whether blast injury to a limb resulted in a change in endothelial phenotype leading to changes to the surrounding tissue.The hind limbs of terminally anaesthetized rabbits were ...
Spear, Abigail M., Davies, Emma M., Taylor, Christopher, Whiting, Rachel, Macildowie, Sara, Kirkman, Emrys, Midwinter, Mark, Watts, Sarah A.   +7 more
openaire   +4 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

DNA Methylation Patterns of Chronic Explosive Breaching in U.S. Military Warfighters

Frontiers in Neurology, 2020
Background: Injuries from exposure to explosions rose dramatically during the Iraq and Afghanistan wars, which motivated investigation of blast-related neurotrauma.
Zhaoyu Wang, Caroline M. Wilson, Caroline M. Wilson, Yongchao Ge, Jeffrey Nemes, Christina LaValle, Angela Boutté, Walter Carr, Walter Carr, Gary Kamimori, Fatemeh Haghighi, Fatemeh Haghighi   +11 more
doaj   +1 more source

Association between 5-Year clinical outcome in patients with nonmedically evacuated mild blast traumatic brain injury and clinical measures collected within 7 days postinjury in combat [PDF]

, 2019
Importance: Although previous work has examined clinical outcomes in combat-deployed veterans, questions remain regarding how symptoms evolve or resolve following mild blast traumatic brain injury (TBI) treated in theater and their association with long ...
Barber, Jason, Dikmen, Sureyya, Fann, Jesse R, Johnson, Ann M, Mac Donald, Christine L, Patterson, Jana, Temkin, Nancy   +6 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source