Results 61 to 70 of about 84,746 (276)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Repetitive Blast Exposure Produces White Matter Axon Damage without Subsequent Myelin Remodeling: In Vivo Analysis of Brain Injury Using Fluorescent Reporter Mice

Neurotrauma Reports, 2021
The potential effects of blast exposure on the brain health of military personnel have raised concerns and led to increased surveillance of blast exposures. Neuroimaging studies have reported white matter abnormalities in brains of service members with a
Donald V. Bradshaw, Yeonho Kim, Amanda Fu, Christina M. Marion, Kryslaine L. Radomski, Joseph T. McCabe, Regina C. Armstrong   +6 more
doaj   +1 more source

THE NEUROPHYSIOLOGICAL EFFECTS OF BLAST EXPOSURE AND MILD TRAUMATIC BRAIN INJURY IN SPECIAL OPERATIONS FORCES SOLDIERS

, 2023
Introduction: Special Operations Forces (SOF) Soldiers sustain frequent low-level occupational blast and mild traumatic brain injury (mTBI). The cumulative impact of blast exposure and mTBI on long-term neurological health is poorly understood.
Powell, Jacob Robert
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Blast Overpressure-Induced Neuroinflammation and Axonal Injury in the Spinal Cord of Ferrets

Brain Sciences
Background: Blast-induced spinal cord injuries (bSCI) account for 75% of all combat-related spinal trauma and are associated with long-term functional impairments.
Gaurav Phuyal, Chetan Y. Pundkar, Manoj Y. Govindarajulu, Rex Jeya Rajkumar Samdavid Thanapaul, Aymen Al-Lami, Ashwathi Menon, Joseph B. Long, Peethambaran Arun   +7 more
doaj   +1 more source

Moderate blast exposure alters gene expression and levels of amyloid precursor protein

, 2017
Objective:To explore gene expression after moderate blast exposure (vs baseline) and proteomic changes after moderate- (vs low-) blast exposure.Methods:Military personnel (N = 69) donated blood for quantification of protein level, and peak pressure ...
Jessica Gill, Hyung-Suk Kim, Angela Yarnell, Walter Carr, Sijung Yun, Ann Cashion, Nicole Osier, Lindsay Arcurio, Kristine C. Dell, Peter Walker, Stephen Ahlers, Matthew LoPresti, Vida Motamedi   +12 more
core   +1 more source

The Effects of Mild Traumatic Brain Injury on Cognitive-Motor Integration for Skilled Performance

Frontiers in Neurology, 2020
Adults exposed to blast and blunt impact often experience mild traumatic brain injury, affecting neural functions related to sensory, cognitive, and motor function.
Lauren E. Sergio, Lauren E. Sergio, Diana J. Gorbet, Diana J. Gorbet, Meaghan S. Adams, Meaghan S. Adams, Meaghan S. Adams, Danielle M. Dobney, Danielle M. Dobney   +8 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Vascular and inflammatory factors in the pathophysiology of blast-induced brain injury

Frontiers in Neurology, 2015
Blast-related traumatic brain injury (TBI) has received much recent attention because of its frequency in the conflicts in Iraq and Afghanistan. This renewed interest has led to a rapid expansion of clinical and animal studies related to blast. In humans,
Gregory A Elder, Miguel A Gama Sosa, Rita eDe Gasperi, James Radford Stone, Dara eDickstein, Fatemeh eHaghighi, Patrick R Hof, Stephen T Ahlers   +7 more
doaj   +1 more source