Results 31 to 40 of about 15,721 (211)

Dynamic Changes in Myofibroblasts Affect the Carcinogenesis and Prognosis of Bladder Cancer Associated With Tumor Microenvironment Remodeling

open access: yesFrontiers in Cell and Developmental Biology, 2022
Bladder cancer (BLCA) is a tumor that possesses significant heterogeneity, and the tumor microenvironment (TME) plays an important role in the development of BLCA.
YiHeng Du   +9 more
doaj   +1 more source

BLCA prognostic model creation and validation based on immune gene-metabolic gene combination

open access: yesDiscover Oncology, 2023
Abstract Background Bladder cancer (BLCA) is a prevalent urinary system malignancy. Understanding the interplay of immunological and metabolic genes in BLCA is crucial for prognosis and treatment. Methods Immune/metabolism genes were extracted, their expression profiles ...
Shao-Yu Yue   +9 more
openaire   +3 more sources

Overexpression of SHMT2 Predicts a Poor Prognosis and Promotes Tumor Cell Growth in Bladder Cancer

open access: yesFrontiers in Genetics, 2021
SHMT2 was overexpressed in many tumors, however, the role of SHMT2 in bladder cancer (BLCA) remains unclear. We first analyzed the expression pattern of SHMT2 in BLCA using the TNMplot, Oncomine, the Cancer Genome Atlas (TCGA), and the Gene Expression ...
Peng Zhang, Qian Yang
doaj   +1 more source

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics [PDF]

open access: yes, 2018
For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types.
A. Abeshouse   +740 more
core   +2 more sources

Comprehensive analysis of normal adjacent to tumor transcriptomes. [PDF]

open access: yes, 2017
Histologically normal tissue adjacent to the tumor (NAT) is commonly used as a control in cancer studies. However, little is known about the transcriptomic profile of NAT, how it is influenced by the tumor, and how the profile compares with non-tumor ...
Aran, Dvir   +8 more
core   +3 more sources

SSA-ME Detection of cancer driver genes using mutual exclusivity by small subnetwork analysis [PDF]

open access: yes, 2016
Because of its clonal evolution a tumor rarely contains multiple genomic alterations in the same pathway as disrupting the pathway by one gene often is sufficient to confer the complete fitness advantage.
De Maeyer, Dries   +3 more
core   +2 more sources

Immunological significance of alternative splicing prognostic signatures for bladder cancer

open access: yesHeliyon, 2022
Background: Bladder cancer (BLCA) is the most common malignant tumor in the genitourinary system, and the complex tumor microenvironment (TME) of BLCA is the main factor in its difficult treatment. Accumulated evidence supports that alternative splicing (
Xinyun Li   +4 more
doaj   +1 more source

Long non-coding RNA containing ultraconserved genomic region 8 promotes bladder cancer tumorigenesis [PDF]

open access: yes, 2016
Ultraconserved regions (UCRs) have been shown to originate non-coding RNA transcripts (T-UCRs) that have different expression profiles and play functional roles in the pathophysiology of multiple cancers.
Avitabile, Concetta   +26 more
core   +2 more sources

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas [PDF]

open access: yes, 2018
Although theMYConcogene has been implicated incancer, a systematic assessment of alterations ofMYC, related transcription factors, and co-regulatoryproteins, forming the proximal MYC network (PMN),across human cancers is lacking.
Abdel-Rahman, Mohamed H.   +740 more
core   +2 more sources

Pan-cancer classifications of tumor histological images using deep learning [PDF]

open access: yes, 2020
Histopathological images are essential for the diagnosis of cancer type and selection of optimal treatment. However, the current clinical process of manual inspection of images is time consuming and prone to intra- and inter-observer variability. Here we
Caruana, Dennis   +8 more
core   +1 more source

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