Results 51 to 60 of about 15,721 (211)

scResponse: A Rank‐Based Method for Identifying Cell States That Contribute to Immunotherapy Response by Single‐Cell Data

Advanced Science, EarlyView.
Although the tumor microenvironment is known to shape immunotherapy response, its key determinants remain elusive, underscoring the critical need for single‐cell resolution analytical frameworks. We present scResponse, an efficient algorithm to quantify single‐cell responses to immunotherapy. By capturing diverse cellular subtypes and states associated
Qi Dong, Haijun Huang, Yuxiu Wang, Bo Jiang, Yuzheng Chen, Huanhuan Xu, Jing Ren, Shengnan Guo, Tianhao Li, Mingjie Zhang, Tianyu Zhai, Wenbo Yang, Kaidong Liu, Cheng Lyu, Jingxuan Kang, Mingshuo Zhang, Yupeng Lu, Binghui Si, Shujun Cao, Dandan Xu, Zong Chen, Dapeng Hao   +21 more
wiley   +1 more source

Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types. [PDF]

, 2019
Cancer cell lines are a cornerstone of cancer research but previous studies have shown that not all cell lines are equal in their ability to model primary tumors.
Aran, D, Butte, AJ, Charalel, J, Chen, B, Goldstein, T, Sirota, M, van 't Veer, LJ, Wolf, DM, Yau, C, Yu, K   +9 more
core   +1 more source

Small Angle Neutron Scattering of Aerogels: Simulations and Experiments

, 1995
A numerical simulation of silica aerogels is performed using diffusion-limited cluster-cluster aggregation of spheres inside a cubic box (with periodic boundary conditions). The volume fraction $c$ is taken to be sufficiently large to get a gel structure
Amar, Anwar Hasmy, Ball, Botet, Brown, Cabane, Cooper, Dietler, Dimon, Egelstaff, Eric Anglaret, Feigin, Ferri, Fisher, Foret, Freltoft, Freltoft, Grey, Guinier, Hasmy, Hasmy, Hasmy, Jacques Pelous, Jullien, Jullien, Jullien, Kolb, Kolb, Mandelbrot, Marie Foret, Meakin, Meakin, Posselt, René Vacher, Rémi Jullien, Schaefer, Sinha, Vacher, Vacher, van Garderen   +39 more
core   +1 more source

Identifying prognostic characteristics of m6A-related glycolysis gene and predicting the immune infiltration landscape in bladder cancer

Cancer Cell International, 2023
Backgrounds Glucose metabolism is associated with the development of cancers, and m6A RNA methylation regulator-related genes play vital roles in bladder urothelial carcinoma (BLCA).
Guanwen Zhou, Yi Li, Xiangguo Ren, Guoliang Qin, Zhaocun Zhang, Haifeng Zhao, Lijian Gao, Xianzhou Jiang   +7 more
doaj   +1 more source

Molecular Tumor Boards in Malignant Melanoma: Uncovering Challenges and Opportunities in a Bicenter Retrospective Analysis in Germany

International Journal of Cancer, EarlyView.
Molecular tumor boards (MTB), interdisciplinary teams that use tumor genomic data to guide personalized treatment decisions, have emerged as a promising strategy in melanoma care, although their real‐world clinical impact remains uncertain. This retrospective study evaluated advanced melanoma patients to assess molecularly guided treatment ...
Glenn Geidel, Theresa Lowinus, Patrick Metzger, Rebecca Czurda, Vincent Schipperges, Ulrike Paul, Alessandra Rünger, Julian Kött, Isabel Heidrich, Saskia Lehr, Julia Kühn, Heiko Becker, Cornelius Miething, Martin Werner, Silke Laßmann, Justus Duyster, Tilman Brummer, Ronald Simon, Winfried Alsdorf, Maximilian Christopeit, Carsten Bokemeyer, Kilian Eyerich, Stefan W. Schneider, David Rafei, Melanie Börries, Frank Meiss, Christoffer Gebhardt   +26 more
wiley   +1 more source

What killed Frame Lake? A precautionary tale for urban planners [PDF]

, 2018
Frame Lake, located within the city of Yellowknife, Northwest Territories, Canada, has been identified as requiring significant remediation due to its steadily declining water quality and inability to support fish by the 1970s.
Cott, Peter A., Falck, Hendrik, Galloway, Jennifer M., Gavel, Melody J., Hanna, Bruce W., Nasser, Nawaf A., Patterson, R Timothy, Roe, Helen M.   +7 more
core   +2 more sources

TEAD4 functions as a prognostic biomarker and triggers EMT via PI3K/AKT pathway in bladder cancer

Journal of Experimental & Clinical Cancer Research, 2022
Background The distant metastasis is the primary cause of cancer morbidity and mortality for bladder cancer (BLCA) paitents. All the recommended therapy for it largely depends on how far the cancer has invaded.
Ming Chi, Jiao Liu, Chenxue Mei, Yaxing Shi, Nanqi Liu, Xuefeng Jiang, Chang Liu, Nan Xue, Hong Hong, Jisheng Xie, Xun Sun, Bo Yin, Xin Meng, Biao Wang   +13 more
doaj   +1 more source

Deciphering diverse cell‐death patterns to predict the prognosis and potential therapy target of hepatocellular carcinoma patients

VIEW, EarlyView.
Abstract Ninety percent of all primary liver malignancies are hepatocellular carcinomas (HCC), making liver cancer the third most common cause of cancer‐associated mortality. Different patterns of programmed cell death (PCD) are crucial for the survival of tumors, and they might serve as a prognostic marker for HCC.
Lin Ding, Qian Li, Wenjing Yang, Te Liu, Tongtong Tian, Yu Liu, Chunyan Zhang, Baishen Pan, Beili Wang, Fan Wu, Wei Guo   +10 more
wiley   +1 more source

Widespread parainflammation in human cancer. [PDF]

, 2016
BackgroundChronic inflammation has been recognized as one of the hallmarks of cancer. We recently showed that parainflammation, a unique variant of inflammation between homeostasis and chronic inflammation, strongly promotes mouse gut tumorigenesis upon ...
Aran, Dvir, Ben-Neriah, Yinon, Biton, Moshe, Butte, Atul J, Hellman, Asaf, Lasry, Audrey, Pikarsky, Eli, Zinger, Adar   +7 more
core   +3 more sources

Prognostic value of LncRNA DLGAP1-AS2 in bladder cancer and its regulatory effect on tumor progression

Discover Oncology
Background Bladder cancer (BLCA) represents one of the most prevalent malignant neoplasms within the urinary system, and its incidence is progressively rising annually in China.
Yuhui Zhao, Xiaotong Wu, Yi Zheng, Huiming Bai, Zhihang Zhang, Mingzhi Li, Xiaofeng He, Chao Yu   +7 more
doaj   +1 more source