Results 61 to 70 of about 12,929 (204)

DataSheet_1_Identification of tryptophan metabolism- and immune-related genes signature and prediction of immune infiltration landscape in bladder urothelial carcinoma.zip [PDF]

, 2023
IntroductionTryptophan metabolism is indirectly involved in immune tolerance and promotes response to anticancer drugs. However, the mechanisms underlying tryptophan metabolism and immune landscape in bladder urothelial carcinoma (BLCA) are not fully ...
Linlin Xue (8462736), Zhaocun Zhang (739108), Guanwen Zhou (12080054), Haifeng Zhao (607312), Guoliang Qin (16753563)   +4 more
core   +1 more source

Molecular Tumor Boards in Malignant Melanoma: Uncovering Challenges and Opportunities in a Bicenter Retrospective Analysis in Germany

International Journal of Cancer, EarlyView.
Molecular tumor boards (MTB), interdisciplinary teams that use tumor genomic data to guide personalized treatment decisions, have emerged as a promising strategy in melanoma care, although their real‐world clinical impact remains uncertain. This retrospective study evaluated advanced melanoma patients to assess molecularly guided treatment ...
Glenn Geidel, Theresa Lowinus, Patrick Metzger, Rebecca Czurda, Vincent Schipperges, Ulrike Paul, Alessandra Rünger, Julian Kött, Isabel Heidrich, Saskia Lehr, Julia Kühn, Heiko Becker, Cornelius Miething, Martin Werner, Silke Laßmann, Justus Duyster, Tilman Brummer, Ronald Simon, Winfried Alsdorf, Maximilian Christopeit, Carsten Bokemeyer, Kilian Eyerich, Stefan W. Schneider, David Rafei, Melanie Börries, Frank Meiss, Christoffer Gebhardt   +26 more
wiley   +1 more source

Source code for ferroptosis gene set activity analysis in BLCA epithelial cells [PDF]

<p>Source code for ferroptosis gene set activity analysis in BLCA epithelial cells </p ...
Zhang, Yi
core   +1 more source

EPHA3 Could Be a Novel Prognosis Biomarker and Correlates with Immune Infiltrates in Bladder Cancer [PDF]

, 2023
Purpose: To assess the mechanism of EPH receptor A3 (EPHA3) and its potential value for immunotherapy in BLCA. Materials and Methods: The Cancer Genome Atlas (TCGA) bladder cancer (BLCA) database and the Gene Expression Omnibus (GEO) database were used ...
Yuzhao Lin, Bin Huang, Yunzhi Yang, Jinwen Liu, Junpeng Liu, Hao Lin, Zewen Zhou, Yifan Jiang, Chongjiang Tian   +8 more
core   +1 more source

Deciphering diverse cell‐death patterns to predict the prognosis and potential therapy target of hepatocellular carcinoma patients

VIEW, EarlyView.
Abstract Ninety percent of all primary liver malignancies are hepatocellular carcinomas (HCC), making liver cancer the third most common cause of cancer‐associated mortality. Different patterns of programmed cell death (PCD) are crucial for the survival of tumors, and they might serve as a prognostic marker for HCC.
Lin Ding, Qian Li, Wenjing Yang, Te Liu, Tongtong Tian, Yu Liu, Chunyan Zhang, Baishen Pan, Beili Wang, Fan Wu, Wei Guo   +10 more
wiley   +1 more source

Multi-institutional quality care initiative (QCI) to improve the care of patients with invasive bladder cancer (BlCa). [PDF]

, 2014
298 Background: Level 1 evidence supports a survival benefit for BlCa pts that receive periop cisplatin chemotherapy in addition to radical cystectomy (RC). Underutilization of multimodal therapy has been reported nationally.
Wassim Kassouf, Joseph W Mashni, Alexandre Zlotta, Robert L. Grubb, Bernard H. Bochner, Dean F. Bajorin, Adam S. Kibel, Peter C. Black, Mark Schoenberg, Seth P. Lerner, Jay Bakul Shah, Ashish M. Kamat, Gary D. Steinberg, null null, Andrew Feifer, Yair Lotan, Walter Michael Stadler, Dahlia Sperling   +17 more
core   +1 more source

Table_2_A Novel Prognostic Signature Based on Ferroptosis-Related Genes Predicts the Prognosis of Patients With Advanced Bladder Urothelial Carcinoma.xls [PDF]

, 2021
Bladder Urothelial Carcinoma (BLCA) is the major subtype of bladder cancer, and the prognosis prediction of BLCA is difficult. Ferroptosis is a newly discovered iron-dependent cell death pathway.
Chunxue Li (8263752), Yajing Wang (447120), Jianjian Zheng (839446), Ji Chen (69329), Wujun Geng (10332453), Enze Lu (11828303), Yuxiao Zhang (2040100), Yating Zhan (5048351), Yeping Li (5100695), Xiaoqi Li (3592895), Rongrong Zhang (217915), Junting Huang (389484)   +11 more
core   +1 more source

Angiogenesis‐associated immune genes as prognostic markers and predictors of immunotherapy response in pancreatic ductal adenocarcinoma

VIEW, EarlyView.
Pancreatic ductal adenocarcinoma exhibits marked angiogenic and immune heterogeneity. We identified 28 angiogenesis‐associated immune genes and developed a seven‐gene AIGScore model comprising FGF2, ADGRB3, MMP2, TYMP, VASH1, VEGFD, and ITGAV. A high AIGScore was associated with poor survival, an immunosuppressive tumor microenvironment, and reduced ...
Qing Chang, Qian Wang, Xiumei Jiang, Yongmei Yang, Ailin Qu   +4 more
wiley   +1 more source

Identifying prognostic characteristics of m6A-related glycolysis gene and predicting the immune infiltration landscape in bladder cancer

Cancer Cell International, 2023
Backgrounds Glucose metabolism is associated with the development of cancers, and m6A RNA methylation regulator-related genes play vital roles in bladder urothelial carcinoma (BLCA).
Guanwen Zhou, Yi Li, Xiangguo Ren, Guoliang Qin, Zhaocun Zhang, Haifeng Zhao, Lijian Gao, Xianzhou Jiang   +7 more
doaj   +1 more source

Targeting KRAS for cancer therapy

British Journal of Pharmacology, EarlyView.
In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia, Ruonan Liu, Tonia A. Adamide, Isis E. Fernandez, Georgios T. Stathopoulos   +4 more
wiley   +1 more source