Bleomycin induced urethral stricture in Hodgkin′s disease
Indian Journal of Urology, 2009 Bleomycin is a glycoprotein that is extensively used in combination with other anti-cancer agents because of its relative lack of hematological and gastrointestinal toxicity. However, pulmonary toxicity is common with bleomycin and limits its therapeutic
Ritesh Tapkire +2 more
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 1983 The anticancer drug, bleomycin, has recently been shown to be light-sensitive by a number of research groups. This photosensitivity extends to its complexes with iron(II), copper(II), cobalt(III) and DNA. Nicking of DNA by photoactivated bleomycin occurs at lower concentrations than under dark conditions.
Douglas, K. T.; id_orcid
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Bleomycin-loaded folic acid-conjugated nanoliposomes: a novel formulation for targeted treatment of oral cancer [PDF]
Frontiers in Bioengineering and BiotechnologyIntroductionTargeted delivery of anticancer drugs holds great promise for enhancing therapeutic efficacy while minimizing adverse effects. The folate receptor (FR)-mediated approach offers a selective strategy to target cancer cells overexpressing FR ...
Elham Saberian +10 more
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Acute Respiratory Failure and Bleomycin: A Case of Bleomycin-Induced Pneumonitis
Galicia ClínicaBleomycin-induced pneumonitis (BIP) is a potentially life-threatening complication of bleomycin chemotherapy, particularly in older patients. We report a case of a 70-year-old female admitted to the hospital with acute respiratory failure, later ...
Sérgio Costa Monteiro +3 more
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Severity of lung injury in cyclooxygenase-2-deficient mice is dependent on reduced prostaglandin E-2 production [PDF]
, 2004 Levels of prostaglandin E-2 (PGE(2)), a potent inhibitor of fibroblast function, are decreased in the lungs of patients with pulmonary fibrosis, which has been shown to be because of limited expression of cyclooxygenase-2 (COX-2).
Martyn L. Foster +21 more
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Magnetic resonance imaging as a non-invasive tool to investigate pulmonary and renal fibrosis in small rodents : method and readout validation, animal model optimization, and substance testing [PDF]
, 2015 Pulmonary fibrosis, an end result of various types of lung damage including interstitial pneumonia and respiratory bronchiolitis (Gross and Hunninghake, 2001; Katzenstein and Myers, 1998; Lazenby et al., 1990) is a lethal disease characterized by ...
Egger, Christine
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Antitumor Effect of Bleomycin Nanoaerosol in Murine Carcinoma Model
Molecules, 2023 Bleomycin, which is widely used as an antitumor agent, possesses serious adverse effects such as pulmonary toxicity. Local nanoaerosol deposition for lung cancer treatment is a promising alternative to drug delivery to lung lesions.
Saida S. Karshieva +8 more
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eJHaem, 2020 Classical Hodgkin lymphoma (HL) patients achieve excellent outcomes; therefore, treatment de‐escalation strategies to spare toxicity have been prioritized.
Jillian R. Gunther +12 more
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Beneficial effects of N-acetylcysteine on protease-antiprotease balance in attenuating bleomycin-induced pulmonary fibrosis in rats [PDF]
Iranian Journal of Basic Medical Sciences, 2020 Objective(s): The role of N-acetylcysteine (NAC) as an anti-oxidant in attenuating bleomycin-induced pulmonary fibrosis has been reported. However, its effect on parenchymal remodeling via regulating the protease-antiprotease balance is not fully defined.
Ritu Kulshrestha +3 more
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Treatment outcomes of AIDS-associated Kaposi's sarcoma under a routine antiretroviral therapy program in Lilongwe, Malawi: bleomycin/vincristine compared to vincristine monotherapy. [PDF]
PLoS ONE, 2014 Despite Kaposi's sarcoma (KS) being the most prevalent AIDS-associated cancer in resource limited settings, optimal treatment options remain unknown.
Albert A Mwafongo +7 more
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