Results 11 to 20 of about 60,523 (282)
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 1983 The anticancer drug, bleomycin, has recently been shown to be light-sensitive by a number of research groups. This photosensitivity extends to its complexes with iron(II), copper(II), cobalt(III) and DNA. Nicking of DNA by photoactivated bleomycin occurs at lower concentrations than under dark conditions.
Douglas, K. T.; id_orcid
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Effect of terahertz irradiation on DNA damage repair in living cells. [PDF]
FEBS Open BioWe investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Ueno Y, Yamazaki S, Hoshina H, Harata M.
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The influence of tramadol and parecoxib on erythmyocin or bleomycin-induced pleurodesis in rabbit: a pilot study [PDF]
, 2021 Introduction: Recurrent pleural effusion secondary to advanced malignant diseases can lead to poor quality of life, recurrent hospital stays and increased hospital costs, which has yet to be extensively explored.
Nik Amin Sahid Nik Lah +6 more
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Cancer, 1967 Bleomycin A, which is a complex of water-soluble peptides produced by a Streptomyces, inhibits DNA synthesis in intact cells of E. coli and HeLa cells and also inhibits Ehrlich carcinoma and Sarcoma 180. When it is injected, it distributes in lung and skin at higher concentration than in blood and kidney.
H, Umezawa +3 more
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Severity of lung injury in cyclooxygenase-2-deficient mice is dependent on reduced prostaglandin E-2 production [PDF]
, 2004 Levels of prostaglandin E-2 (PGE(2)), a potent inhibitor of fibroblast function, are decreased in the lungs of patients with pulmonary fibrosis, which has been shown to be because of limited expression of cyclooxygenase-2 (COX-2).
McAnulty, R J +35 more
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Magnetic resonance imaging as a non-invasive tool to investigate pulmonary and renal fibrosis in small rodents : method and readout validation, animal model optimization, and substance testing [PDF]
, 2015 Pulmonary fibrosis, an end result of various types of lung damage including interstitial pneumonia and respiratory bronchiolitis (Gross and Hunninghake, 2001; Katzenstein and Myers, 1998; Lazenby et al., 1990) is a lethal disease characterized by ...
Egger, Christine
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Antitumor Effect of Bleomycin Nanoaerosol in Murine Carcinoma Model
Molecules, 2023 Bleomycin, which is widely used as an antitumor agent, possesses serious adverse effects such as pulmonary toxicity. Local nanoaerosol deposition for lung cancer treatment is a promising alternative to drug delivery to lung lesions.
Saida S. Karshieva +8 more
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Lung fibrosis 10 years after cessation of bleomycin therapy. [PDF]
, 2008 Bleomycin (BLM) is a chemotherapeutic agent used for the treatment of several types of malignancy, including germ cell tumors, lymphoma, and certain types of squamous-cell carcinoma.
Yanagihara, Katunori +14 more
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eJHaem, 2020 Classical Hodgkin lymphoma (HL) patients achieve excellent outcomes; therefore, treatment de‐escalation strategies to spare toxicity have been prioritized.
Jillian R. Gunther +12 more
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Bleomycin induced urethral stricture in Hodgkin′s disease
Indian Journal of Urology, 2009 Bleomycin is a glycoprotein that is extensively used in combination with other anti-cancer agents because of its relative lack of hematological and gastrointestinal toxicity. However, pulmonary toxicity is common with bleomycin and limits its therapeutic
Ritesh Tapkire +2 more
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