Results 21 to 30 of about 62,115 (257)

Meleagrin Isolated from the Red Sea Fungus Penicillium chrysogenum Protects against Bleomycin-Induced Pulmonary Fibrosis in Mice

Biomedicines, 2022
The Red Sea marine fungus Penicillium chrysogenum (Family: Ascomycota) comprises a panel of chemically diverse natural metabolites. A meleagrin alkaloid was isolated from deep-sediment-derived P.
Sameh S. Elhady, Marwa S. Goda, Eman T. Mehanna, Mahmoud A. Elfaky, Abdulrahman E. Koshak, Ahmad O. Noor, Hanin A. Bogari, Rania T. Malatani, Reda F. A. Abdelhameed, Alaa S. Wahba   +9 more
doaj   +1 more source

Vascular sclerosing effects of bleomycin on cutaneous veins: a pharmacopathologic study on experimental animals [PDF]

Anais Brasileiros de Dermatologia, 2017
: Background: Varicose veins and the complications of venous disease are common disorders in humans. Objective: To study the effects of bleomycin as a potential new sclerosing agent and its adverse events in treating varicose veins. Methods: Bleomycin-
Khalid M AlGhamdi, Ashok Kumar, Abdelkader E. Ashour, Ammar C. AL-Rikabi, Abdullah Hasan AlOmrani, Shaik Shaffi Ahamed   +5 more
doaj   +2 more sources

Intralesional bleomycin for treatment of a recalcitrant wart in an immunocompromised patient: A safe, effective, and underutilized therapy

Clinical Case Reports, 2022
Injectable bleomycin is infrequently used for recalcitrant warts despite its efficacy, acceptable safety profile, and high patient satisfaction compared with other treatment modalities.
Tracy Ngo, Hannah Hwang, Bijal Amin, Steven R. Cohen   +3 more
doaj   +1 more source

Downregulation of PTEN mediates bleomycin-induced premature senescence in lung cancer cells by suppressing autophagy

Journal of International Medical Research, 2020
Objective Bleomycin is an important chemotherapeutic drug that activates premature senescence to decrease the tumorigenic process. We aimed to investigate the role of phosphatase and tensin homolog deleted on chromosome ten (PTEN) in bleomycin-induced ...
Xiaoyan Sai, Chu Qin, Yan Wu, Yinying Zhao, Tao Bian   +4 more
doaj   +1 more source

Comparison of intralesional bleomycin with/without doxycycline in the primary management of pediatric lymphangiomas

Formosan Journal of Surgery, 2021
Background: Although surgical excision is the treatment of choice for lymphangiomas, recently many centers are practicing intralesional sclerotherapy as the primary modality. The purpose of this study was to review the efficacy of intralesional Bleomycin,
Naresh M Pawar, Aditya Pratap Singh, Arun Kumar Gupta, Vinita Chaturvedi, Dinesh Kumar Barolia   +4 more
doaj   +1 more source

Bleomycin-induced pulmonary fibrosis in mouse lungs.

, 2017
(A) Images of lungs from mice that were either subject to nasal administration of methylene blue (right) or not (left).
Yuko Yamada (3749758), Katsuko Sudo (222875), Masahiko Kuroda (142101), Masakatsu Takanashi (372895), Shinobu Ueda (52123), Shin-ichiro Ohno (3778615)   +5 more
core   +1 more source

Dioxygen Activation by Copper-Bleomycin: Theoretical Considerations [PDF]

, 2014
Density functional theory (DFT) calculations are employed to calculate probable reaction intermediates in dioxygen activation by bleomycin-ligated copper – Cu(I)-dioxygen, Cu(I)-superoxo and Cu(II)-hydroperoxo.
Papp, Anita, Silaghi-Dumitrescu, Radu, Surducan, Mihai   +2 more
core   +1 more source

Bleomycin-induced skin toxicity: a case of flagellate dermatitis. [PDF]

, 2021
Bleomycin, an antineoplastic, glycopeptide antibiotic is commonly used to treat several malignancies, in particular, lymphomas, testicular carcinoma, and squamous cell carcinoma. As bleomycin degradation by enzyme hydrolase is less in the skin and lungs,
Steenkamp, Ilana, Pretorius, Monique, Spies, Leana, van der Linde, Gerhard, Monique Pretorius, Gerhard Van der Linde, Pretorius, Monique ; Steenkamp, Ilana ; Spies, Leana ; Van der Linde, Gerhard, Ilana Steenkamp, Leana Spies   +8 more
core   +1 more source

The Effect of Artesunate on Bleomycin‑Induced Pulmonary Fibrosis

Acta Clinica Croatica
Despite new drug alternatives, no curative treatment for idiopathic pulmonary fibrosis (IPF) currently exists. This study aimed to evaluate the effects of artesunate on fibrosis, pulmonary hypertension, and inflammation-related changes in IPF.
Aysun Şengul, Oğuzhan Okutan, Bülent Altınsoy, Ceyda Anar, Onur Yazıcı, Fazilet Dede, Sibel Köktürk, Cüneyt Özer, Osman Fuat Sönmez, Gökhan Metin   +9 more
doaj   +1 more source

Enhancement of bleomycin production in Streptomyces verticillus through global metabolic regulation of N-acetylglucosamine and assisted metabolic profiling analysis

Microbial Cell Factories, 2020
Background Bleomycin is a broad-spectrum glycopeptide antitumor antibiotic produced by Streptomyces verticillus. Clinically, the mixture of bleomycin A2 and bleomycin B2 is widely used in combination with other drugs for the treatment of various cancers.
Hong Chen, Jiaqi Cui, Pan Wang, Xin Wang, Jianping Wen   +4 more
doaj   +1 more source