Results 61 to 70 of about 98,039 (291)
Trigonelline mitigates bleomycin-induced idiopathic pulmonary fibrosis in mice
Asian Pacific Journal of Tropical BiomedicineObjective: To evaluate the effect of trigonelline on bleomycin-induced idiopathic pulmonary fibrosis (IPF) and to explore its underlying mechanisms using network pharmacology.
Swapnil Gavhane +9 more
doaj +1 more source
New markers of bleomycin resistance [PDF]
, 2019 Resistance to chemotherapy is one of the main problems of this type of therapy. Studies carried out determine the usefulness of predictive biomarkers to improve this treatment.
Burgos-Molina, Antonio Manuel +2 more
core
Food Frontiers, EarlyView.Hesperetin inhibits bleomycin‐induced idiopathic pulmonary fibrosis by regulating gut microbiota and acetate and butyrate levels via the gut‐lung axis. ABSTRACT In the post‐epidemic and aging era, idiopathic pulmonary fibrosis (IPF) has become one of the major diseases endangering human health.
Xia Meng +9 more
wiley +1 more source
Move beyond free radical theory of aging
iMetaOmics, EarlyView.Free radicals play a dual, dose‐dependent role in aging. Low levels activate the key sensor adenosine 5'‐monophosphate‐activated protein kinase (AMPK), promoting cell survival mechanisms like autophagy and enhancing mitochondrial health. High levels, however, push AMPK to initiate cell death pathways, such as apoptosis. This positions AMPK as a central
Xiaofeng Dai, Meilan Hu, Ruohan Lyu
wiley +1 more source
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT This study explored the therapeutic efficacy of oxymatrine (OMT, C15H24N2O2) in a murine model of cigarette smoke (CS)‐induced chronic obstructive pulmonary disease (COPD) and elucidated its underlying mechanisms. A COPD model was established in mice through prolonged exposure to CS, followed by intraperitoneal administration of OMT (50 mg/kg)
Shuang Zhou, Ju‐Xiang Zhu, Jing Li
wiley +1 more source
A Novel Murine Model of Acute Laryngeal Injury After Intubation
The Laryngoscope, EarlyView.This study describes a novel murine model of acute laryngeal injury (ALgI) after intubation. Chemomechanical injury was performed to the posterior glottis of adult mice using a bleomycin‐dipped wire brush under endoscopic guidance, resulting in reduced glottic mobility, increased posterior glottic thickness, and increased collagen expression. This safe,
Ruth J. Davis +4 more
wiley +1 more source
The Use of Filgrastim in Patients with Hodgkin Lymphoma Receiving ABVD
International Journal of Hematology-Oncology and Stem Cell Research, 2017 Background: There is conflicting data about the increased risk of pulmonary toxicity when granulocyte-stimulating factor (G-CSF) is given in combination with bleomycin.
Adam F. Binder +2 more
doaj
Characterization of acute lung injury in the bleomycin rat model
Physiological Reports, 2023 The aim of this study was to describe and characterize the pathophysiological changes occurring during the early inflammatory phase (first 3 days) in the rat bleomycin model of lung injury preceding the development of fibrosis.
Anil Hari Kadam, Jan E. Schnitzer
doaj +1 more source
Heterologous matrix metalloproteinase gene promoter activity allows In Vivo real-time imaging of Bleomycin-induced Lung fibrosis in transiently transgenized mice [PDF]
, 2017 Idiopathic pulmonary fibrosis is a very common interstitial lung disease derived from chronic inflammatory insults, characterized by massive scar tissue deposition that causes the progressive loss of lung function and subsequent death for respiratory ...
Donofrio, Gaetano +8 more
core +1 more source
Phytotherapy Research, EarlyView.ABSTRACT Psychological stress (or simply “stress”) is a major contributor to chronic disease worldwide, affecting 35% of the global population, including younger generations. Furthermore, it plays a significant role in human premature aging; hence, its detrimental effects on people's health compel us to comprehend and control the ways in which ...
Marco Duarte +3 more
wiley +1 more source