Results 71 to 80 of about 1,389,504 (295)
On Separation Between the Degree of a Boolean Function and the Block Sensitivity [PDF]
, 2021 In this paper we study the separation between two complexity measures: the degree of a Boolean function as a polynomial over the reals and its block sensitivity. We show that separation between these two measures can be improved from $ d^2(f) \geq bs(f) $, established by Tal, to $ d^2(f) \geq (\sqrt{10} - 2)bs(f) $.
openaire +2 more sources
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
The Underlying Mechanism of Modulation of Transient Receptor Potential Melastatin 3 by protons
Frontiers in Pharmacology, 2021 Transient receptor potential melastatin 3 channel (TRPM3) is a calcium-permeable nonselective cation channel that plays an important role in modulating glucose homeostasis in the pancreatic beta cells.
Md Zubayer Hossain Saad +8 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
e-PolymersAmphiphilic block copolymers only with specific degree of polymerization of both PEG segment and polypeptide chain could form injectable ROS-responsive hydrogels, which protect normal cells from oxidative damage.
Ji Yingying +4 more
doaj +1 more source
Fabrication of Upconverting Hybrid Nanoparticles for Near-Infrared Light Triggered Drug Release
Advances in Materials Science and Engineering, 2014 Low tissue penetration and harmful effects of (ultraviolet) UV or visible light on normal tissue limit exploiting nanocarriers for the application of light-controlled drug release.
Ranran Zhang +8 more
doaj +1 more source
Molecular mechanisms in haematological malignancies [PDF]
, 2009 Haematopoiesis requires the constant production of large numbers of peripheral blood cells. This process is under tight control of transcription factor networks as well as cytokines, growth factors and hormones.
Avellino, Roberto +2 more
core
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Surgery Open Science, 2020 Background: Transversus abdominis plane block with liposomal bupivacaine has been studied as an effective method of reducing the need for postoperative opioids and increasing same-day discharge rates.
Alexander L. Colonna +7 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source