Results 71 to 80 of about 501,341 (265)

Reservoir Sensitivity Analysis of Tight Sandstone and Its Controlling Factors: A Case Study from Chang 4+5 to Chang 6 Reservoirs in N 212 Well Block of Nanniwan Oilfield, Ordos Basin

open access: yesGeofluids, 2023
Reservoir sensitivity can lead to the physical or chemical reactions to block the pore throat. It is helpful for reducing the damage on tight sandstone reservoir to study the reservoir sensitivity and its controlling factors. This paper mainly focuses on
Pingtian Fan   +5 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

A Tight Lower Bound on Certificate Complexity in Terms of Block Sensitivity and Sensitivity [PDF]

open access: yes, 2014
Sensitivity, certificate complexity and block sensitivity are widely used Boolean function complexity measures. A longstanding open problem, proposed by Nisan and Szegedy, is whether sensitivity and block sensitivity are polynomially related. Motivated by the constructions of functions which achieve the largest known separations, we study the relation ...
Andris Ambainis, Krisjanis Prksis
openaire   +3 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Diagnostic Performance of Conventional Smear, Liquid‑Based Cytology and Cell Block in Nigeria: A Comparative Study of 814 Specimens

open access: yesHealth Research in Africa
Introduction. Conventional smear is the standard cytological preparation, but liquid‑based cytology and cell block may improve diagnostic yield. Comparative data from Nigeria are scarce.
Efosa Bolaji Odigie   +1 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Synthesis of PEGylated polypeptides bearing thioether pendants for injectable ROS-responsive hydrogels

open access: yese-Polymers
Amphiphilic block copolymers only with specific degree of polymerization of both PEG segment and polypeptide chain could form injectable ROS-responsive hydrogels, which protect normal cells from oxidative damage.
Ji Yingying   +4 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

open access: yesFEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa   +3 more
wiley   +1 more source

Fabrication of Upconverting Hybrid Nanoparticles for Near-Infrared Light Triggered Drug Release

open access: yesAdvances in Materials Science and Engineering, 2014
Low tissue penetration and harmful effects of (ultraviolet) UV or visible light on normal tissue limit exploiting nanocarriers for the application of light-controlled drug release.
Ranran Zhang   +8 more
doaj   +1 more source

Reducing the pain: A cost-effectiveness analysis of transversus abdominis plane block using liposomal bupivacaine for outpatient laparoscopic ventral hernia repair

open access: yesSurgery Open Science, 2020
Background: Transversus abdominis plane block with liposomal bupivacaine has been studied as an effective method of reducing the need for postoperative opioids and increasing same-day discharge rates.
Alexander L. Colonna   +7 more
doaj   +1 more source

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