Results 171 to 180 of about 681,701 (257)

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

Apolipoprotein D, a Novel Ligand for CD36, Is Essential for Blood-Brain Barrier Integrity. [PDF]

Circulation
Gong CX, Shi PX, Huang YJ, Dai Y, Hu LL, Cheng XF, Zhang S, He MT, Wang JH, Meng ZY, Fang YL, Wang BQ, Zhao Y, He CK, Yang GQ, Zi WJ, Qiu ZM, Li FL, Lin S, Lu H, Zhao CH, Zhang C, Liu ZY, Dong MQ, Ouyang Q, Zheng HT, Niu JQ, Mei F, Sun BL, Zhou J, Xie Q, Li FF, Yang QW.   +32 more
europepmc   +1 more source

Respiratory Organ‐on‐a‐Chip for Disease Modeling: From Architecture to Functional Integration

Advanced Healthcare Materials, EarlyView.
Respiratory organ‐on‐a‐chip (ROC) models capture key mechanical and cellular cues of the human respiratory system, enabling quantitative dissection of disease mechanisms. This review links ROC architectures to disease modeling, functional integration, and commercialization, and proposes a decision framework that aligns model complexity with mechanistic
Jinzhuo Hu, Yongjie Tang, Sidi Liu, Tao Xu, Qian Liu   +4 more
wiley   +1 more source

In Silico Prediction and Validation of the Permeability of Small Molecules Across the Blood-Brain Barrier. [PDF]

Int J Mol Sci
Ajao F, de Jong-Hoogland D, Ulmschneider JP, Ulmschneider MB, Lambden E.   +4 more
europepmc   +1 more source

A Physiological Microfluidic Blood–Brain‐Barrier Model for In Vitro Study of Nanoparticle Trafficking and Accumulation

Advanced Healthcare Materials, EarlyView.
A human microfluidic blood‐brain barrier (mBBB) model enables spatially resolved comparison of nanoparticle trafficking. Extracellular vesicles (EVs), liposomes, and nanoplastics exhibit distinct transport and disruption behaviors, revealing that membrane composition and uptake pathways govern BBB interaction.
Bryan B. Nguyen, Neona M. Lowe, Sophia Kellogg, Kuan‐Wei Huang, Hannah O'Toole, Elizabeth J. Hale, Venktesh S. Shirure, Bhupinder S. Shergill, Steven C. George, Randy P. Carney   +9 more
wiley   +1 more source

Detection of inflammation-related blood-brain barrier dysfunction using PET and MR imaging: a pilot study. [PDF]

Sci Rep
Hilbrig CF, Baumann B, Sievert W, Halbgebauer R, Huber-Lang M, Beer AJ, Rasche V, Löffler J.   +7 more
europepmc   +1 more source

Recapitulating Endochondral Ossification for Bone Repair: From Development to Engineering Strategy

Advanced Healthcare Materials, EarlyView.
This review summarizes the developmental basis of endochondral ossification (ECO) and its applications in bone tissue engineering (BTE). It first outlines the key biological processes and signaling pathways underlying ECO, then discusses biomaterial‐based engineering strategies derived from these principles, and finally highlights future directions for
Yiqi Su, Zihao He, Qianqian Chen, Long Chen, Caiyi Wei, Zijin Zhou, Jianhao Lin, Hui Li, Dan Xing   +8 more
wiley   +1 more source

Effect of aging and Varroa parasitism on the paracellular and transcellular permeability of the honeybee blood-brain barrier. [PDF]

PLoS One
Quigley T, Amdam G.
europepmc   +1 more source

Mesoporous Silica Nanoparticles in Biomedicine: Advances and Prospects

Advanced Materials, EarlyView.
Mesoporous silica nanoparticles offer unique properties like high surface area, tunable pores, and functionalization. They excel in drug delivery, tissue engineering, and stimuli‐responsive therapies, enabling targeted and controlled treatments. With roles in cancer therapy and diagnostics, their clinical translation requires addressing challenges in ...
Miguel Manzano, María Vallet‐Regí
wiley   +1 more source

Slowly crossing the blood-brain barrier takes time. [PDF]

Alzheimers Dement
Backes WH, Verstappen D, de Jong JJA, Jansen JFA.   +3 more
europepmc   +1 more source