Results 191 to 200 of about 352,933 (230)

Diffusion‐Based Generative Model With Scaffold‐Hopping Strategy Yields Highly Potent Bioactive Molecules

Advanced Science, EarlyView.
SMarT‐Diff introduces a multi‐objective generative paradigm that integrates scaffold hopping with structure‐aware scoring to enable controlled exploration beyond the training distribution. The framework consistently balances drug‐likeness, synthesizes accessibility and bioactivity, yielding chemically diverse candidates with enhanced properties.
Yuwei Yang, Xiaoqing Gong, Shukai Gu, Jing Li, Bo Liu, Yanan Tian, Qianqian Zhang, Xiaojun Yao, Huanxiang Liu   +8 more
wiley   +1 more source

A Microgel Platform Enables Site‐Specific Intestinal Delivery of Lactoferrin, Improving its Bioavailability for Targeted Alleviating Liver Injury and Colitis

Advanced Science, EarlyView.
This work first time reports an eco‐friendly desert plant food‐based polysaccharide ASKP microgels which have intestinal site‐specific release properties which can achieve small‐intestine or colon targeting capability via different cross‐linking chemistry.
Huiling Yan, Yixuan Li, Shanan Chen, Pengcheng Du, Kaiwen Wu, Hui Zhang, Kasper Hettinga, Lina Zhang, Gergely Toldi, Fazheng Ren, Yuan Li   +10 more
wiley   +1 more source

Aptamer-Based Delivery of Genes and Drugs Across the Blood-Brain Barrier. [PDF]

Pharmaceuticals (Basel)
Yang L, Yin Y, Liu X, Guo B.
europepmc   +1 more source

Xenogeneic Mitochondrial Transplantation Improves Selected Age‐Associated Phenotypes in Mice

Advanced Science, EarlyView.
Yak‐derived xenogeneic mitochondrial transplantation improves selected age‐associated phenotypes in mice, enhances mitochondrial functional readouts, and engages host mitochondrial quality‐control pathways. Broad tissue biodistribution, increased ATP production and mtDNA copy number, reduced ROS levels and dysfunctional mitochondria, improved motility ...
Wenpeng Li, Xijia Wang, Yaning Hu, Zhen Yang, Tian Niu, Xingbo Zhao   +5 more
wiley   +1 more source

Modulating Blood-Brain Barrier Metabolites of Broiler Chickens Through Dietary Flaxseed Oil. [PDF]

Biomolecules
Suberu SA, Omaliko PC, Ekunseitan DA, Lichti NI, Cooper BR, Fasina YO.   +5 more
europepmc   +1 more source

An Edible Biohybrid Platform Accomplishes In Situ Fenton‐Mediated Enteral Nanoplastics Aging and Excretion

Advanced Science, EarlyView.
An edible biohybrid platform triggers nanoplastics (NPs) aging and agglomeration by in situ generating hydroxyl radicals within the intestine. The enlarged NPs are unable to penetrate the intestine and are subsequently excreted. Simultaneously, probiotic biofilms reinforce the intestinal barrier.
Su Zhou, Anran Yan, Haowei Guo, Ping Chen, Qiang Chu   +4 more
wiley   +1 more source

Nanoscopic analysis of tight junction organization in in vitro blood-brain barrier models. [PDF]

Fluids Barriers CNS
Waldow A, Brachner A, Perriere N, Neuhaus W, Piontek J.   +4 more
europepmc   +1 more source

Mannose-6-Phosphate-Tagged Liposomes Exhibit Increased Transcytosis Across Human Blood-Brain Barrier Model. [PDF]

Pharmaceutics
Dinamarca MC, Sevarika B, McNeil S.
europepmc   +1 more source

Neuroinflammatory changes in acute myeloid leukemia: Evidence for blood-brain barrier disruption and glial activation. [PDF]

Hemasphere
Febo M, Sorcini D, Mirarchi A, Cogliati P, Stella A, Sportoletti P, Ermakova O, Mandarano M, Marchetti MC, Riccardi C, Falini B, Migliorati G, Arcuri C, Bruscoli S, Bereshchenko O.   +14 more
europepmc   +1 more source