Results 91 to 100 of about 80,920 (248)

Blood-cerebrospinal fluid barrier opening by modified single pulse transcranial focused shockwave

, 2022
Transcranial focused shockwave (FSW) is a novel noninvasive brain stimulation that can open blood-brain barriers (BBB) and blood-cerebrospinal fluid barriers (BCSFB) with a single low-energy (energy flux density 0.03 mJ/mm2) pulse and low-dose ...
Wei-Hao Liao (211533), Meng-Ting Lin (3552338), Yi Kung (11195856), Ming-Yen Hsiao (9857351), Chueh-Hung Wu (298196), Wen-Shiang Chen (488749)   +5 more
core   +1 more source

Noninvasive Focal Gene Delivery into the Cerebellum of Non‐Human Primates using Focused Ultrasound

Advanced Science, EarlyView.
Focal and non‐invasive viral vector delivery in non‐human primates remains a major challenge in translational neuroscience. Low‐intensity focused ultrasound was used to transiently open the blood–brain barrier and enable targeted gene delivery to the cerebellum.
Noelia Esteban‐García, José A. Pineda‐Pardo, Inés Trigo‐Damas, Marta Gutiérrez, Marta Castillo‐Ortiz, Megan Carrillo, Alejandro Reinares‐Sebastian, Víctor Medina‐Chavarrías, Itay Rachmilevitch, Masahiko Takada, José A. Obeso, Javier Blesa   +11 more
wiley   +1 more source

Mannitol and the blood-labyrinth barrier

Journal of Otolaryngology - Head and Neck Surgery, 2017
Background Characterization of the blood labyrinth barrier (BLB) is extremely important to determine whether the BLB can be manipulated pharmacologically. However, experiments to investigate the BLB are technically difficult to perform.
Trung N. Le, Brian W. Blakley
doaj   +1 more source

Prmt6 Deficiency or Inhibition Restores Microglial Homeostasis and Promotes Scar‐Limited Repair in Adult Spinal Cord Injury

Advanced Science, EarlyView.
After spinal cord injury, adult microglia remain persistently activated with chronic PRMT6 (protein arginine methyltransferase 6) upregulation. Prmt6 deficiency or inhibition reestablishes microglial homeostasis and promotes a scar‐limited repairment, enhancing axonal regrowth.
Weilin Peng, Zhengqiang Wu, Yu Xiong, Zhongya Gao, Yishan Liu, Ziyi Wang, Haibin Wang, Chaofeng Han, Wenxiang Chu, Xuhua Lu   +9 more
wiley   +1 more source

Editorial: The brain barriers in diseases of the nervous system

Frontiers in Cellular Neuroscience, 2023
Marek Joukal, Lucy Vulchanova, Petr Dubový   +2 more
doaj   +1 more source

Schematic view of the choroid plexus epithelial cell culture method as a human blood cerebrospinal fluid barrier model.

, 2018
Schematic view of the choroid plexus epithelial cell culture method as a human blood cerebrospinal fluid barrier model.
Tomoya Ikeda (5459309), Miho Watanabe (205880), Junko Toyomura (5459312), Akihiro Ohyama (5459306), Takaki Ishikawa (5459315), Naoto Tani (5459303)   +5 more
core   +1 more source

'Acanthamoeba' produces disseminated infection in locusts and traverses the locust blood-brain barrier to invade the central nervous system [PDF]

, 2010
BACKGROUND: Many aspects of Acanthamoeba granulomatous encephalitis remain poorly understood, including host susceptibility and chronic colonization which represent important features of the spectrum of host-pathogen interactions.
Mortazavi, Parisa Nakhostin, Kirk, R., Goldsworthy, Graham, Parisa N Mortazavi, Ruth Kirk, Naveed A Khan, Kirk, Ruth, Khan, Naveed Ahmed, Khan, Naveed A, Goldsworthy, Graham J., Mortazavi, Parisa N, Graham Goldsworthy   +11 more
core   +1 more source

Wireless, Adaptable and Fully Implantable Battery‐powered Devices for Optical Stimulation of the Spinal Cord in Small Rodents

Advanced Science, EarlyView.
Current technologies for spinal cord optogenetic stimulation rely on external power sources and face reliability constraints in freely behaving animals. Here, a fully implantable, battery‐powered optoelectronic device is introduced, enabling operation in any selected environment with wireless recharging for months‐long stimulation.
Shahriar Shalileh, Adan Moallemi, Elham Mohseni Vadeghani, Samuel Tretjakov, Brianna Tsuyuki, Alexander Golab, Benjamin Rever, Wolfram Tetzlaff, Dena Shahriari   +8 more
wiley   +1 more source

Convergence of quantum dot barcodes with microfluidics and signal processing for multiplexed high-throughput infectious disease diagnostics.

, 2007
Through the convergence of nano- and microtechnologies (quantum dots and microfluidics), we have created a diagnostic system capable of multiplexed, high-throughput analysis of infectious agents in human serum samples.
Kain, Kevin C, Xiang, Qing, Lafferty, Erin I, Farcas, Gabriella A, Perrault, Steven D, Chan, Warren CW, Lee, Jeongjin A, Klostranec, Jesse M, Rhee, Alex   +8 more
core   +1 more source

A Dual‐Channel Synergistic Ultrasensitive Biosensor for Tumor Liquid Biopsy

Advanced Science, EarlyView.
ABSTRACT Liquid biopsy technology, which detects circulating tumor DNA (ctDNA) in cerebrospinal fluid, plays a crucial role in the early diagnosis and precision treatment of gliomas. However, the intrinsically low abundance and rapid clearance of ctDNA pose substantial challenges for conventional analytical techniques, such as droplet digital PCR and ...
Yu Sun, Jing Zhang, Chenqing Liu, Jing Lou, Sihui Wang, Xiangtian Ji, Xiaofang Zhao, Shirui Xu, Jingyu Feng, Bin Liu, Chao Chang, Qinggang Ge, Jun Yang   +12 more
wiley   +1 more source