IMMUNOLOGICAL ASPECTS OF NEUROSYPHILIS
Инфекция и иммунитет, 2015 Reduced incidence of syphilis was reported in Russia over last years, along with increased prevalence of neurosyphilis. The issues of the mechanisms of the damage of nervous system and the immune response to syphilis are actual.
M. L. Chuhlovina, E. A. Bichun
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Modeling immune functions of the mouse blood-cerebrospinal fluid barrier in vitro: primary rather than immortalized mouse choroid plexus epithelial cells are suited to study immune cell migration across this brain barrier. [PDF]
, 2016 BACKGROUND The blood-cerebrospinal fluid barrier (BCSFB) established by the choroid plexus (CP) epithelium has been recognized as a potential entry site of immune cells into the central nervous system during immunosurveillance and neuroinflammation ...
Lazarevic, Ivana +3 more
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Advanced Science, EarlyView.Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang +6 more
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Neurobrucellosis evaluated by reibergram. A case report
Revista Habanera de Ciencias Médicas, 2018 Introduction: Brucellosis is a zoonotic and an endemic disease in many areas around the world. The main cause of infection is the intake of unpasteurized milk or the contact with infected animals.
Alberto Juan Dorta Contreras +2 more
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Lumbar drainage following aneurysmal subarachnoid haemorrhage and the role of cytokine and adhesion molecules in the pathogenesis of delayed ischaemic neurological deficit [PDF]
, 2011 Introduction Delayed ischaemic neurological deficit (DIND) following aneurysmal subarachnoid haemorrhage (aSAH) is a significant cause of morbidity and mortality.
Al-Tamimi, Yahia
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"In vitro" evaluation of blood-brain barrier transport [PDF]
, 2014 The blood-brain barrier (BBB), which is formed by brain capillary endothelial cells, effectively protects the central nervous system (CNS) from potential neurotoxic agents and maintains the brain homeostasis for synaptic signaling (Abbott, 2004 ...
Dieu, Le-Ha
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Advanced Science, EarlyView.This study identifies S100A14 in tumor‐derived exosomes as a key driver of brain metastasis. S100A14 targets PIAS3 in astrocytes, activating STAT3 signaling and promoting immunosuppressive MDSCs recruitment via chemokine secretion. Germacrone, a natural compound, binds S100A14 to disrupt this axis, effectively inhibiting brain metastasis with low ...
Qian Feng +13 more
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Culture models to study leukocyte trafficking across the choroid plexus
Fluids and Barriers of the CNS, 2013 Background A critical point during the course of central nervous system infection is the influx of leukocytes from the blood into the brain across the blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCSFB).
Tenenbaum Tobias +5 more
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Friend, Not Foe: Lowered Tissue Reactivity to Long‐Term Polyimide Implants
Advanced Science, EarlyView.The choice of optimal neural probe designs remains a major challenge in the field of neurotechnology. This study investigated the biocompatibility of several probe variations, including material, thickness, width, and implantation strategy. It highlights the clear advantage of soft polyimide probes over stiff silicon probes for better device ...
Corinne Orlemann +11 more
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Capsule independent uptake of the fungal pathogen Cryptococcus neoformans into brain microvascular endothelial cells. [PDF]
, 2012 Cryptococcosis is a life-threatening fungal disease with a high rate of mortality among HIV/AIDS patients across the world. The ability to penetrate the blood-brain barrier (BBB) is central to the pathogenesis of cryptococcosis, but the way in which this
May, Robin C +10 more
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