Molecular Mechanisms of Organic Anion Transporting Polypeptide-Mediated Organic Anion Clearance at the Blood-Cerebrospinal Fluid Barrier. [PDF]
Mol Pharmacol, 2023 Sun A, Hagenbuch B, Kelly EJ, Wang J.
europepmc +1 more source
Advanced Science, EarlyView.GALK1 acts as a protein kinase beyond the phosphorylation of galactose. GALK1 phosphorylates TIMM13 at Y73 in the cytoplasm. This phosphorylation prevents premature oxidative folding of TIMM13 and ensures its entrance into the intermembrane space of mitochondrion, positively regulating mitochondrial respiration.
Chang Woo Ko +5 more
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The Blood-Cerebrospinal Fluid Barrier May Play a Role in Alzheimer Disease Pathogenesis. [PDF]
Radiology, 2022 Chiang GC.
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Advanced Science, EarlyView.A blue‐light‐crosslinked bilayer hydrogel was developed for local optic nerve repair. The adhesive GM‐Odex outer layer seals and anchors the lesion, while the non‐adhesive GM‐imid inner layer releases MPDA‐Cle without obstructing CSF flow. This system modulates oxidative and inflammatory microenvironments, supports oligodendrocyte differentiation and ...
Tonghe Pan +13 more
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In Vitro Models of the Blood-Cerebrospinal Fluid Barrier and Their Applications in the Development and Research of (Neuro)Pharmaceuticals. [PDF]
Pharmaceutics, 2022 Dabbagh F, Schroten H, Schwerk C.
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Targeted Mechanogenetics to Modulate Specific Deep Neural Circuits
Advanced Science, EarlyView.This study introduces mechanogenetics, a nanobubble‐enhanced sonogenetic strategy for selective modulation of feeding‐related neural circuits in the mouse lateral hypothalamus. Mechanogenetic stimulation modulates feeding behavior through glutamatergic projections from the lateral hypothalamus to the ventral tegmental area, highlighting its potential ...
Xuandi Hou +3 more
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Chronotherapy of Brain Diseases: Assessment of the Circadian Rhythms of Efflux Transporters at the Blood-cerebrospinal Fluid Barrier [PDF]
The choroid plexus (CP) is an integral part of the blood cerebrospinal-fluid barrier (BCSFB). The CP is formed by a monolayer of cuboidal epithelial cells united by tight junctions.
Furtado, André Filipe Lino
core
Effect of hyperoxia, hypercapnia, and hypoxia on blood-cerebrospinal fluid barrier
, 1961 Page 959: Miriam Lending, Lawrence B. Slobody, and Joan Mestern, "Effect of hyperoxia, hypercapnia, and hypoxia on blood-cerebrospinal fluid barrier." Line 3 from bottom of abstract should read: Hyperoxia alone did not cause significant changes.
Lawrence B. Slobody +2 more
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Blood Cerebrospinal Fluid Barrier Function Disturbance Can Be Followed by Amyloid-β Accumulation. [PDF]
J Clin Med, 2022 Suzuki Y, Nakamura Y, Igarashi H.
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American Journal of Hematology, EarlyView.ABSTRACT Immune‐mediated thrombotic thrombocytopenic purpura (iTTP) is a life‐threatening thrombotic microangiopathy characterized by acute neurological manifestations and long‐term sequelae related to microvascular brain injury. Cerebral small vessel disease (cSVD), detectable on MRI through lacunes, microbleeds, white matter hyperintensities, and ...
Addolorata Truma +13 more
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