Results 131 to 140 of about 80,920 (248)

The interplay between molecular architecture, pharmacology, and suspected adverse drug reactions associated with nonsteroidal androgen antagonists in the United Kingdom

British Journal of Clinical Pharmacology, EarlyView.
Aims This work aimed to correlate potential links between the suspected adverse drug reaction (ADR) profile of licensed nonsteroidal androgen receptor antagonists (NSARA) with their unique chemical properties and known off‐target polypharmacology. Methods Physicochemical and polypharmacology data were curated from the Electronic Medicines Compendium ...
Simrit Dhillon, Albert A. Antolin, Alan M. Jones   +2 more
wiley   +1 more source

A physiologically relevant blood–cerebrospinal fluid barrier model to study the permeability of neurodegenerative biomarkers

European Journal of Cell Biology
The blood–cerebrospinal fluid barrier (BCSFB) is formed by the choroid plexus and represents the interface between the blood and cerebrospinal fluid (CSF).
Petra Majerova, Krutika Khiratkar, Michaela Skrabanova, Dominika Olesova, Lubica Fialova, Kevin James, Jozef Vegh, Juraj Piestansky, Andrej Kovac   +8 more
doaj   +1 more source

Active Uptake of Oxycodone at Both the Blood-Cerebrospinal Fluid Barrier and The Blood-Brain Barrier without Sex Differences: A Rat Microdialysis Study. [PDF]

Pharm Res, 2023
Bällgren F, Hammarlund-Udenaes M, Loryan I.   +2 more
europepmc   +1 more source

Chronotherapy of Brain Diseases: Assessment of the Circadian Rhythms of Efflux Transporters at the Blood-cerebrospinal Fluid Barrier

The choroid plexus (CP) is an integral part of the blood cerebrospinal-fluid barrier (BCSFB). The CP is formed by a monolayer of cuboidal epithelial cells united by tight junctions.
Furtado, André Filipe Lino
core  

Blood-Cerebrospinal Fluid Barrier Permeability in Alzheimer's Disease

, 2011
The role of blood-cerebrospinal fluid barrier (BCB) dysfunction in Alzheimer's disease (AD) has been addressed but not yet established. We evaluated the BCB integrity in 179 samples of cerebrospinal fluid (CSF) retrospectively collected from AD patients ...
Henrik Zetterberg, Niels Andreasen, Blennow, Kaj,, Zetterberg, H, Zetterberg, Henrik,, Tormod Fladby, Chalbot, Sonia, Andreasen, N,, Grundke-Iqbal, I, Andreasen, Niels, Iqbal, K, Khalid Iqbal, Chalbot, S, Kaj Blennow, Blennow, K, Fladby, T, Fladby, Tormod, Grundke-Iqbal, Inge, Sonia Chalbot, Inge Grundke-Iqbal, Iqbal, Khalid   +20 more
core   +1 more source

Infusion rate adjustment in enzyme replacement therapy with pabinafusp alfa for mucopolysaccharidosis II

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Enzyme replacement therapy (ERT) for mucopolysaccharidosis II (MPS II) requires long‐term, weekly intravenous infusions often lasting over 3 h each time, which can burden paediatric patients and caregivers and negatively affect their quality of life and treatment compliance.
Kimitoshi Nakamura, Norio Sakai, Hideaki Hirai, Naoko Takasao, Ryo Ibaraki, Tatsuyoshi Yamamoto, Yuji Sato   +6 more
wiley   +1 more source

The use of Reibergram in Cuban neuroimmunology

Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta, 2018
Cerebrospinal fluid (CSF) is an indispensable source of information for the diagnosis and progress of numerous neurological diseases. Reibergrams are diagrams in which the functionality of the blood-CSF barrier and the intrathecal synthesis of ...
Alvaro Pérez-Pérez
doaj  

Overcoming intranasal delivery barriers with ultrastable polyzwitterionic siRNA nanocages for enhanced glioblastoma therapy

BMEMat, EarlyView.
A ROS‐responsive, zwitterionic nanocage enables stable, intranasal siRNA delivery to glioblastoma, promoting deep tumor penetration via non‐degradative pathways and trigeminal nerve transport. This platform achieves durable gene silencing and tumor suppression, offering a non‐invasive, storage‐stable strategy for treating glioma and other neurological ...
Jingwen Xie, Jingxing Si, Xiaobei Deng, Jing Tan, Ruijie Zhu, Jizhou Qi, Gaoxia Ma, Bin Wang, Yi Wang, Yunzhou Guo, Yuping Chen, Shiqun Shao, Youqing Shen   +12 more
wiley   +1 more source

A Systematic Review on Disease‐Modifying Therapies in Parkinsonian Disorders

Clinical Pharmacology &Therapeutics, EarlyView.
Parkinsonian disorders, including Parkinson's disease, Lewy body dementia, multiple system atrophy, and progressive supranuclear palsy, are progressive neurodegenerative conditions with no treatment options to slow disease progression. This systematic review provides an overview of evidence of disease‐modifying therapies that have been evaluated in ...
Pepijn P.N.M. Eijsvogel, Lars M.G. Smits, Philip H.C. Kremer, Geert Jan Groeneveld   +3 more
wiley   +1 more source

NLRP3-dependent lipid droplet formation contributes to posthemorrhagic hydrocephalus by increasing the permeability of the blood-cerebrospinal fluid barrier in the choroid plexus. [PDF]

Exp Mol Med, 2023
Zhang Z, Guo P, Liang L, Jila S, Ru X, Zhang Q, Chen J, Chen Z, Feng H, Chen Y.   +9 more
europepmc   +1 more source