Results 91 to 100 of about 700,468 (343)

Interaction of major facilitator superfamily domain containing 2A with the blood–brain barrier

Neural Regeneration Research
The functional and structural integrity of the blood–brain barrier is crucial in maintaining homeostasis in the brain microenvironment; however, the molecular mechanisms underlying the formation and function of the blood–brain barrier remain poorly ...
Yilun Ma, Taiwei Dong, Fei Luan, Juanjuan Yang, Feng Miao, Peifeng Wei   +5 more
doaj   +1 more source

Sistem Penghantaran Obat Melewati Barrier Darah Otak [PDF]

, 2004
Brain barrier is effective barrier in drug delivery to brain. For effectiveness drug deliveryneed be desaigned a delivery with nanoparticle technology. Nanoparticles are solid colloidalparticles ranging in size from 1 to 1000 nm that are utilized as drug
Syukri, Y. (Yandi)
core   +1 more source

Portable Low‐Field Magnetic Resonance Imaging in People With Human Immunodeficiency Virus

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The aging population of people with HIV (PWH) raises heightened concerns regarding accelerated aging and dementia. Portable, low‐field MRI (LF‐MRI) is an innovative technology that could enhance access and facilitate routine monitoring of PWH.
Annabel Sorby‐Adams, Malachi Keo, Jennifer Guo, Daire Daly, Richard Ahern, Kimon Zachary, Gregory Robbins, Rajesh T. Gandhi, Bragi Sveinsson, Adam de Havenon, Kevin N. Sheth, Otto Rapalino, Juan Eugenio Iglesias Gonzales, W. Taylor Kimberly, Shibani S. Mukerji   +14 more
wiley   +1 more source

Beyond wrecking a wall: revisiting the concept of blood–brain barrier breakdown in ischemic stroke

Neural Regeneration Research
The blood–brain barrier constitutes a dynamic and interactive boundary separating the central nervous system and the peripheral circulation. It tightly modulates the ion transport and nutrient influx, while restricting the entry of harmful factors, and ...
Julia Castillo-González, Elena González-Rey   +1 more
doaj   +1 more source

Persistent Leukoencephalopathy Following H1N1 Infection Associated With a Novel MYRF Variant (p.Gly735Asp)

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Mutations in myelin regulatory factor (MYRF) are linked to demyelinating disorders. We report a 38‐year‐old male who developed acute symmetric leukoencephalopathy mimicking a stroke following an influenza A virus infection. While clinical symptoms markedly improved with corticosteroids, MRI revealed persistent white matter lesions, contrasting
Jinghan Hu, Leiyun Huang, Wan Zhu, Min Peng, Qiang Gong, Jing Qian   +5 more
wiley   +1 more source

Cytokine-mediated blood brain barrier disruption as a conduit for cancer/chemotherapy-associated neurotoxicity and cognitive dysfunction [PDF]

, 2016
Neurotoxicity is a common side effect of chemotherapy treatment, with unclear molecular mechanisms. Clinical studies suggest that the most frequent neurotoxic adverse events affect memory and learning, attention, concentration, processing speeds and ...
Abraham, Ahdieh, Ahles, Ahles, Al-Dasooqi, Al-Dasooqi, Al-Dasooqi, Alkam, Argaw, Argaw, Asahi, Ashburner, Bauer, Bercik, Blanco, Bona, Bourke, Boussios, Bowen, Bower, Brown, Brown, Brown, Caliceti, Capuron, Chen, Cheng, Chidlow, Chodobski, Collado-Hidalgo, Corps, Cummins, D'Alessio, Dantzer, Deprez, Deprez, Dietrich, Dietrich, Dietrich, Ferguson, Frank, Gahtan, Galvez, Gangloff, Gatti, Genschaft, Ginos, Goehler, Guo, Han, Henriksen, Higashida, Hjermstad, Holden, Holmes, Horky, in't Veld, Inagaki, Janelsins, Jenkins, Jenkins, Jiao, Jickling, Komaki, Krabbe, Krabbe, Laye, Lepage, Li, Lischper, Liu, Logan, Logan, McDonald, McDonald, Meyers, Minter, Mustian, Natah, Nokia, Nyuyki, Pan, Pan, Papadakis, Patel, Proescholdt, Quan, Riazi, Rochfort, Rodriguez, Roque, Schreibelt, Seigers, Seigers, Sharma, Sharma, Sharma, Simo, Sodeck, Sonis, Sparkman, Stringer, Stringer, Tannock, Trask, Vardy, Vermeer, Villena, Vink, Vries, Wang, Wardill, Wardill, Wardill, Wardill, Wardill, Wardill, Wardill, Wong, Wu, Zonis   +120 more
core   +1 more source

Function of Connexins in the Interaction between Glial and Vascular Cells in the Central Nervous System and Related Neurological Diseases

Neural Plasticity, 2018
Neuronal signaling together with synapse activity in the central nervous system requires a precisely regulated microenvironment. Recently, the blood-brain barrier is considered as a “neuro-glia-vascular unit,” a structural and functional compound ...
Yinan Zhao, Yanguo Xin, Zhiyi He, Wenyu Hu   +3 more
doaj   +1 more source

Imaging glutathione depletion in the rat brain using ascorbate-derived hyperpolarized MR and PET probes. [PDF]

, 2018
Oxidative stress is a critical feature of several common neurologic disorders. The brain is well adapted to neutralize oxidative injury by maintaining a high steady-state concentration of small-molecule intracellular antioxidants including glutathione in
Carroll, Valerie N, Flavell, Robert R, Keshari, Kayvan R, Kurhanewicz, John, Mutch, Christopher A, Qin, Hecong, Sriram, Renuka, Villanueva-Meyer, Javier E, von Morze, Cornelius, Wang, Zhen Jane, Wilson, David M   +10 more
core   +1 more source

Heparin‐Derived Theranostic Nanoprobes Overcome the Blood–Brain Barrier and Target Glioma in Murine Model [PDF]

, 2022
Sumanta Samanta, Vadim Le Joncour, Olivia Wegrzyniak, Vignesh Kumar Rangasami, Harri Ali‐Löytty, Taehun Hong, Ram Kumar Selvaraju, Ola Åberg, Jöns Hilborn, Pirjo Laakkonen, Oommen P. Varghese, Olof Eriksson, Horacio Cabral, Oommen P. Oommen   +13 more
openalex   +1 more source

Real‐World Investigation of Satralizumab in Patients With Neuromyelitis Optica Spectrum Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Satralizumab, a monoclonal antibody targeting the interleukin‐6 receptor, has demonstrated efficacy in clinical trials for neuromyelitis optica spectrum disorder (NMOSD). However, its real‐world effectiveness and safety compared to conventional immunosuppressive therapies remain uncertain.
Li‐Tsung Lin, Hui‐An Lin, Sheng‐Feng Lin   +2 more
wiley   +1 more source