Results 271 to 280 of about 966,153 (399)

Facilitating DNAzyme transport across the blood-brain barrier with nanoliposome technology. [PDF]

Sci Rep
Hoseinifar MJ, Aghaz F, Asadi Z, Asadi P, Nedaei SE, Arkan E, Pourmotabbed A, Bahrami G, Pourmotabbed T.   +8 more
europepmc   +1 more source

Noninvasive Assessment of β‐Secretase Activity Through Click Chemistry‐Mediated Enrichment of Neuronal Extracellular Vesicles to Detect Alzheimer's Disease

Advanced Science, EarlyView.
This study presents the NEV β‐secretase activity assay, a groundbreaking method for noninvasive evaluation of β‐secretase activity in Alzheimer's disease (AD) patients, enabling the generation of individualized β‐secretase activity profiles.
Hyoyong Kim, Junseok Lee, Audrey Qian, You‐Ren Ji, Ryan Zhang, Qixin Hu, Christopher Kazu Williams, Han‐Yu Chuang, Matthew D. Smalley, Yaya Xu, Liang Gao, Mary C. Mayo, Ting Zhang, Edwin M. Posadas, Zaldy S. Tan, Harry V. Vinters, Keith Vossel, Shino Magaki, Yazhen Zhu, Hsian‐Rong Tseng   +19 more
wiley   +1 more source

Blood-Brain Barrier (BBB) Dysfunction in CNS Diseases: Paying Attention to Pericytes. [PDF]

CNS Neurosci Ther
Yu T, Wang Z, Chen Y, Xiang Y, Wu M, Zhang M, Yin X, Chen Z.   +7 more
europepmc   +1 more source

Inhibition by sumatriptan of central trigeminal neurones only after blood‐brain barrier disruption [PDF]

, 1993
Holger Kaube, Karen L. Hoskin, Peter J. Goadsby   +2 more
openalex   +1 more source

The blood-brain barrier: Bottleneck in brain drug development

NeuroRx, 2005
W. Pardridge
semanticscholar   +1 more source

S‐ketamine Alleviates Neuroinflammation and Attenuates Lipopolysaccharide‐Induced Depression Via Targeting SIRT2

Advanced Science, EarlyView.
S‐ketamine binds directly to SIRT2, facilitating its interaction with NF‐κB p65. This interaction reduces the acetylation of NF‐κB p65 and inhibits its activation, thereby exerting anti‐inflammatory and antidepressant effects. Created by BioRender.
Cong Lin, Xiaoxuan Zhou, Mingqi Li, Cong Zhang, Haojiang Zhai, Haohong Li, Hongshuang Wang, Xiaohui Wang   +7 more
wiley   +1 more source

Understanding the blood brain barrier: current state and therapeutic implications. [PDF]

EBioMedicine
eBioMedicine.
europepmc   +1 more source

Fine structural study of Mg-ATPase and alkaline phosphatase activities in the blood-brain barrier of ischemic rats.

, 1986
Shigehiko Ishiharajima, Shinsuke Fujita, Nobutaka Yamada, Gorô Asano   +3 more
openalex   +2 more sources

Re‐evaluating the role of astrocytes in blood‐brain barrier induction [PDF]

, 1993
Jocelyn Holash, Drew M. Noden, Patricia A. Stewart   +2 more
openalex   +1 more source

Post‐Translational Modifications in Cilia and Ciliopathies

Advanced Science, EarlyView.
This review synthesizes current understanding of post‐translational modifications (PTMs) in ciliary proteins and emphasizes their roles in ciliary formation, homeostasis, and signaling. This review also discusses the implication of PTM dysregulation in ciliopathies and explores therapeutic strategies targeting PTM‐modifying enzymes.
Jie Ran, Jun Zhou
wiley   +1 more source