Results 81 to 90 of about 957,746 (360)
Aging and Cancer, EarlyView.Aging weakens the blood–brain barrier (BBB), increasing susceptibility to CNS cancers and complicating treatment. This review examines BBB deterioration, its impact on drug delivery, and potential interventions like targeting neuroinflammation and advanced therapies.
Quang La, Aiman Baloch, David F. Lo
wiley +1 more source
Fluids and Barriers of the CNS, 2018 This review considers efflux of substances from brain parenchyma quantified as values of clearances (CL, stated in µL g−1 min−1). Total clearance of a substance is the sum of clearance values for all available routes including perivascular pathways and ...
Stephen B. Hladky, Margery A. Barrand
doaj +1 more source
Electron transmission through a periodically driven graphene magnetic barrier [PDF]
, 2016 The kinetic transport of electrons through graphene magnetic barriers is studied theoretically in presence of an external time harmonic scalar potential. The transmission coefficients are calculated in the framework of the non-perturbative Floquet theory using transfer matrix method.
arxiv +1 more source
Properties of 1D two-barrier quantum pump with harmonically oscillating barriers [PDF]
Physical Review B vol. 74, p.125317 (2006), 2005 We study a one-dimensional quantum pump composed of two oscillating delta-functional barriers. The linear and non-linear regimes are considered. The harmonic signal applied to any or both barriers causes the stationary current. The direction and value of the current depend on the frequency, distance between barriers, value of stationary and oscillating
arxiv +1 more source
Microglial activation and blood–brain barrier permeability in cerebral small vessel disease
Brain : a journal of neurology, 2021 See Edison (doi:10.1093/brain/awab149) for a scientific commentary on this article. Using advanced brain imaging techniques, Walsh et al. provide evidence of both neuroinflammation and increased blood-brain barrier permeability in patients with cerebral ...
J. Walsh +11 more
semanticscholar +1 more source
Blood-brain- barrier co-culture models to study nanoparticle penetration : focus on co-culture systems [PDF]
, 2015 The blood-brain barrier, as a physical, active transport and metabolic barrier represents the main obstacle in the treatment of central nervous system diseases.
Bocsik, Alexandra +4 more
core
Hepatic acute phase response protects the brain from focal inflammation during postnatal window of susceptibility [PDF]
, 2018 Perinatal inflammation is known to contribute to neurodevelopmental diseases. Animal models of perinatal inflammation have revealed that the inflammatory response within the brain is age dependent, but the regulators of this variation remain unclear.
Anthony, D C +6 more
core +2 more sources
HPDL Variant Type Correlates With Clinical Disease Onset and Severity
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Recently, a mitochondrial encephalopathy due to biallelic HPDL variants was described, associated with a broad range of clinical manifestations ranging from severe, infantile‐onset neurodegeneration to adolescence‐onset hereditary spastic paraplegia. HPDL converts 4‐hydroxyphenylpyruvate acid (4‐HPPA) into 4‐hydroxymandelate (4‐HMA),
Eun Hye Lee +19 more
wiley +1 more source
Pharmaceutics, 2021 The blood–brain barrier is a major obstacle in treating brain-related disorders, as it does not allow the delivery of drugs into the brain. We developed a method for predicting blood–brain barrier penetrating peptides to facilitate drug delivery into the
Vinod Kumar +4 more
doaj +1 more source
Leukotrienes increase blood-brain barrier permeability following intraparenchymal injections in rats [PDF]
, 1985 To examine whether leukotrienes could increase blood–brain barrier permeability, rats were anesthetized and injected intravenously with Evans blue. Ten microliters of vehicle, of leukotrienes B 4 , C 4 , or E 4 , or of arachidonic acid was injected over ...
Abdel-Halim +10 more
core +1 more source