Results 151 to 160 of about 3,850,623 (241)

Folic acid inhibits 5-methyltetrahydrofolate transport across the blood-cerebrospinal fluid barrier: Clinical biochemical data from two cases. [PDF]

JIMD Rep, 2022
Akiyama T, Kuki I, Kim K, Yamamoto N, Yamada Y, Igarashi K, Ishihara T, Hatano Y, Kobayashi K.   +8 more
europepmc   +1 more source

Serum Chitotriosidase Links to Activated Glia at Chronic Active Lesion Rims in Multiple Sclerosis Brain

Annals of Neurology, EarlyView.
Objective The objective of this study was to explore the association between 18 kDa translocator protein (TSPO)‐positron emission tomography (PET)–measurable glial activation and serum chitotriosidase (CHIT1) in people with multiple sclerosis (pwMS), and its expression in postmortem MS brain tissue.
Venla Ahola, Maija Saraste, Edoardo Pedrini, Joel Tuomaala, Luzia Buchholz, Markus Matilainen, Johanna Lindenberg, Eeva‐Christine Brockmann, Maria Sofia Martire, Sofia Sandgren, David Leppert, Jens Kuhle, Tanja Kuhlmann, Martina Absinta, Laura Airas   +14 more
wiley   +1 more source

Oxytocin Affects Barriergenesis in the Blood-Brain Barrier and the Blood-Cerebrospinal Fluid Barrier In Vitro Monoculture Transwell Models. [PDF]

Dev Neurobiol
Averchuk AS, Aleksandrova OP, Zhdankina VI, Perepelitsa ES, Berdnikov AK, Salina KО, Yurchenko SО, Salmina AB.   +7 more
europepmc   +1 more source

Cortisol promotes breast-to-brain metastasis through the blood-cerebrospinal fluid barrier. [PDF]

Cancer Rep (Hoboken), 2022
Herrera RA, Deshpande K, Martirosian V, Saatian B, Julian A, Eisenbarth R, Das D, Iyer M, Neman J.   +8 more
europepmc   +1 more source

Functional Polymer‐Engineered Magnetic Nanoparticles as Dual‐Modal Theragnostic Probes for Early Alzheimer's Disease Detection and Therapy

Advanced NanoBiomed Research, EarlyView.
The nanoparticle consists of a 3 nm iron oxide core functionalized with an amphiphilic polymer coating containing Aβ‐targeting DSA moieties and biocompatible PEG chains. This design supports measurable transport in a BBB‐related model and specific interaction with Aβ species, while providing MRI contrast enhancement for diagnosis and therapeutic ...
Ao Shen, Liwen Zhang, Helen Forgham, Jiayuan Zhu, Xumin Huang, Changkui Fu, Ibrahim Javed, Thomas P. Davis, Ruirui Qiao   +8 more
wiley   +1 more source

Using Manganese-Enhanced DCE-MRI to Assess Blood-Cerebrospinal Fluid Barrier Transport. [PDF]

Magn Reson Med
Perera C, Feng Z, Nizari S, Muza P, Katsiva C, Kalber TL, Lythgoe MF, Harrison IF, Stuckey DJ, Wells JA.   +9 more
europepmc   +1 more source

Age‐related differences in hydroxychloroquine‐associated adverse events: A pharmacovigilance study based on the FDA Adverse Event Reporting System

British Journal of Clinical Pharmacology, EarlyView.
Aims This real‐world pharmacovigilance study utilizes FDA Adverse Event Reporting System (FAERS) data (2004–2024) to characterize age‐related disparities in hydroxychloroquine (HCQ)‐associated adverse events (AEs), addressing gaps in age‐stratified risk assessment. Methods Disproportionality analysis (reporting odds ratios, RORs) and parametric Weibull
Guanghan Sun, Jingrong Yang, Lei Wan, Xia Xu, Jing Wang   +4 more
wiley   +1 more source

Choroid plexus organoids mimic amyloid uptake at the blood-cerebrospinal fluid-barrier. [PDF]

Front Cell Neurosci
Municio C, Sapidou K, Apsley EJ, Fernandez-Otero M, Arber CE, Wray S, Carro E, Pellegrini L.   +7 more
europepmc   +1 more source

Claudin-5a is essential for the functional formation of both zebrafish blood-brain barrier and blood-cerebrospinal fluid barrier. [PDF]

Fluids Barriers CNS, 2022
Li Y, Wang C, Zhang L, Chen B, Mo Y, Zhang J.   +5 more
europepmc   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source