Protocol to analyze the transmigration efficiency of T. brucei using an in vitro model of the blood-cerebrospinal fluid barrier [PDF]
STAR Protocols, 2022 Summary: At present, the only approach to investigate the transmigration of Trypanosoma brucei, the causative agent of human African trypanosomiasis, from blood to cerebrospinal fluid is through animal experiments.
Alexander Herrmann +5 more
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Non-Invasive MRI of Blood–Cerebrospinal Fluid Barrier Function [PDF]
Nature Communications, 2020 The blood–cerebrospinal fluid barrier (BCSFB) is an important interface for brain homeostasis. Here the authors describe a non-invasive MRI technique for the quantitative assessment of BCSFB function.
P. G. Evans +10 more
doaj +2 more sources
Simulated microgravity‐induced dysregulation of cerebrospinal fluid immune homeostasis by disrupting the blood–cerebrospinal fluid barrier [PDF]
Brain and BehaviorBackground The blood–cerebrospinal fluid barrier (BCSFB) comprises the choroid plexus epithelia. It is important for brain development, maintenance, function, and especially for maintaining immune homeostasis in the cerebrospinal fluid (CSF).
Jing Yang +11 more
doaj +2 more sources
Choroid plexus and the blood–cerebrospinal fluid barrier in disease [PDF]
Fluids and Barriers of the CNS, 2020 The choroid plexus (CP) forming the blood–cerebrospinal fluid (B-CSF) barrier is among the least studied structures of the central nervous system (CNS) despite its clinical importance.
Peter Solár +4 more
doaj +2 more sources
Linking peripheral low-grade inflammation and blood-cerebrospinal fluid barrier leakage in schizophrenia spectrum disorders – A retrospective analysis [PDF]
Brain, Behavior, & Immunity - HealthBackground: Social impairments and low-grade inflammation (LGI) are associated with psychotic disorders (e.g. schizophrenia spectrum disorders). Social impairments are important symptoms of the disease nonetheless a disturbed social interaction and ...
Timo Jendrik Faustmann +5 more
doaj +2 more sources
Investigating changes in blood-cerebrospinal fluid barrier function in a rat model of chronic hypertension using non-invasive magnetic resonance imaging [PDF]
Frontiers in Molecular Neuroscience, 2022 Chronic hypertension is a major risk factor for the development of neurodegenerative disease, yet the etiology of hypertension-driven neurodegeneration remains poorly understood.
Charith Perera +10 more
doaj +2 more sources
Gut microbiota regulates blood‐cerebrospinal fluid barrier function and Aβ pathology [PDF]
EMBO Journal, 2023 Junhua Xie +2 more
exaly +2 more sources
The Potential Roles of Blood–Brain Barrier and Blood–Cerebrospinal Fluid Barrier in Maintaining Brain Manganese Homeostasis [PDF]
Nutrients, 2021 Ningning Zhao, Zhao Ningning
exaly +2 more sources
Cerebrospinal Fluid–Basic Concepts Review
Biomedicines, 2023 Cerebrospinal fluid plays a crucial role in protecting the central nervous system (CNS) by providing mechanical support, acting as a shock absorber, and transporting nutrients and waste products.
Natalia Czarniak +3 more
doaj +1 more source
Strain-dependent disruption of bloodâcerebrospinal fluid barrier byStreptoccocus suisin vitro [PDF]
FEMS Immunology & Medical Microbiology, 2005 Streptococcus suis capsular type 2 is an important agent of diseases including meningitis among pigs worldwide, and is also a zoonotic agent. The barrier function of the choroid plexus epithelium that constitutes the structural basis for the blood-cerebrospinal fluid (CSF) barrier has not been elucidated yet in bacterial meningitis. We investigated the
Tobias, Tenenbaum +7 more
openaire +2 more sources