Results 31 to 40 of about 80,920 (248)

The Connected Steady State Model and the Interdependence of the CSF Proteome and CSF Flow Characteristics

Frontiers in Neuroscience, 2017
Here we show that the hydrodynamic radii-dependent entry of blood proteins into cerebrospinal fluid (CSF) can best be modeled with a diffusional system of consecutive interdependent steady states between barrier-restricted molecular flux and bulk flow of
Fabian Metzger, Daniel Mischek, Frédéric Stoffers   +2 more
doaj   +1 more source

Molecular anatomy and functions of the choroidal blood-cerebrospinal fluid barrier in health and disease [PDF]

, 2018
International audienceThe barrier between the blood and the ventricular cerebrospinal fluid (CSF) is located at the choroid plexuses. At the interface between two circulating fluids, these richly vascularized veil-like structures display a peculiar ...
Catala, Martin, Jean-François Ghersi-Egea, Strazielle, Nathalie, Doetsch, Fiona, Nathalie Strazielle, Martin Catala, Engelhardt, Britta, Ghersi-Egea, Jean-François, Britta Engelhardt, Silva-Vargas, Violeta, Violeta Silva-Vargas, Fiona Doetsch   +11 more
core   +1 more source

The embryonic blood-CSF barrier has molecular elements for specific glucose transport and for the general transport of molecules via transcellular routes.

, 2010
In vertebrates, early brain development takes place at the expanded anterior end of the neural tube, which is filled with embryonic cerebrospinal fluid (E-CSF).
Bueno i Torrens, David, 1965-, Parvas, Maryam, David Bueno, Maryam Parvas   +3 more
core   +1 more source

The blood–cerebrospinal fluid barrier

, 2015
Exposure to organic mercury compounds promotes primarily neurological effects. Although methylmercury is recognized as a potent neurotoxicant, its transfer into the central nervous system (CNS) is not fully evaluated.
Lohren, Hanna, Bornhorst, Julia (Dr.), Galla, Hans-Joachim, Schwerdtle, Tanja (Prof. Dr.)   +3 more
core   +2 more sources

Subarachnoid Hemorrhage Increases Level of Heme Oxygenase-1 and Biliverdin Reductase in the Choroid Plexus

Frontiers in Cellular Neuroscience, 2020
Subarachnoid hemorrhage is a specific, life-threatening form of hemorrhagic stroke linked to high morbidity and mortality. It has been found that the choroid plexus of the brain ventricles forming the blood-cerebrospinal fluid barrier plays an important ...
Peter Solár, Peter Solár, Peter Solár, Václav Brázda, Václav Brázda, Shahaf Levin, Alemeh Zamani, Radim Jančálek, Radim Jančálek, Petr Dubový, Marek Joukal   +10 more
doaj   +1 more source

Effect of prolonged convulsions on the blood-cerebrospinal fluid barrier

, 1959
The effect of prolonged convulsions (induced by Metrazol or electroshock) on the blood-cerebrospinal fluid barrier of puppies was evaluated with the use of radioiodinated human serum albumin by measuring its rate of passage from the plasma into the ...
Lawrence B. Slobody, Joan Mestern, Miriam Lending   +2 more
core   +1 more source

Selective localization of IgG from cerebrospinal fluid to brain parenchyma

Journal of Neuroinflammation, 2018
Background Encounter of autoantibodies with specific antigens can lead to hypersensitivity reactions and pathology. In multiple sclerosis and neuromyelitis optica spectrum disease (NMOSD), immunoglobulin-G (IgG) deposition has been observed in ...
Marlene Thorsen Mørch, Sofie Forsberg Sørensen, Reza Khorooshi, Nasrin Asgari, Trevor Owens   +4 more
doaj   +1 more source

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Breaking Barriers: Unveiling Sex-Related Differences in Cerebrospinal Fluid Analysis—A Narrative Review

Biology
(1) Background: The recent emphasis on sexual and gender diversity’s impact on human health underscores the need for tailored diagnostic and therapeutic approaches in neurology.
Raffaella Candeloro, Caterina Ferri, Tiziana Bellini, Maura Pugliatti, Massimiliano Castellazzi   +4 more
doaj   +1 more source

The blood-brain and the blood-cerebrospinal fluid barriers: function and dysfunction [PDF]

, 2009
The central nervous system (CNS) is tightly sealed from the changeable milieu of blood by the blood-brain barrier (BBB) and the blood-cerebrospinal fluid (CSF) barrier (BCSFB).
Sorokin, Lydia, Engelhardt, Britta
core   +1 more source