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The Lancet, 2000
Under normal circumstances, the coagulation system is balanced in favour of anticoagulation. Thrombin is the key effector enzyme of the clotting cascade. Antagonists of vitamin K inhibit a vitamin-K-dependent post-translational modification of several coagulation proteins, which is required for these proteins to attain a phospholipid-binding ...
E, IKKALA, H R, NEVANLINNA
+6 more sources
Under normal circumstances, the coagulation system is balanced in favour of anticoagulation. Thrombin is the key effector enzyme of the clotting cascade. Antagonists of vitamin K inhibit a vitamin-K-dependent post-translational modification of several coagulation proteins, which is required for these proteins to attain a phospholipid-binding ...
E, IKKALA, H R, NEVANLINNA
+6 more sources
Biochemistry (Moscow), 2002
The process of tissue factor initiated blood coagulation is discussed. Reactions of the blood coagulation cascade are propagated by complex enzymes containing a vitamin K-dependent serine protease and an accessory cofactor protein that are assembled on a membrane surface in a calcium-dependent manner.
S. Butenas, K. G. Mann, null Butenas
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The process of tissue factor initiated blood coagulation is discussed. Reactions of the blood coagulation cascade are propagated by complex enzymes containing a vitamin K-dependent serine protease and an accessory cofactor protein that are assembled on a membrane surface in a calcium-dependent manner.
S. Butenas, K. G. Mann, null Butenas
openaire +2 more sources
Transfusion and Apheresis Science, 2018
Hemostasis is the physiological control of bleeding and is initiated by subendothelial exposure. Platelets form the primary vascular seal in three stages (localization, stimulation and aggregation), which are triggered by specific interactions between platelet surface receptors and constituents of the subendothelial matrix.
Edward L G, Pryzdial +5 more
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Hemostasis is the physiological control of bleeding and is initiated by subendothelial exposure. Platelets form the primary vascular seal in three stages (localization, stimulation and aggregation), which are triggered by specific interactions between platelet surface receptors and constituents of the subendothelial matrix.
Edward L G, Pryzdial +5 more
openaire +2 more sources
Blood Coagulation and Coagulation Tests
Medical Clinics of North America, 1984The hemostatic mechanism has evolved to provide efficient protection from traumatic blood loss and yet maintain the blood in a fluid state in the circulation as a whole. Recent advances in biochemistry have provided both detailed understanding of hemostasis and clinically useful coagulation assays to exploit this understanding.
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Supercharged blood coagulation
Blood, 2009In this issue of Blood, Undas and colleagues show that patients with AMI are able to mount an enhanced blood clotting response in the peripheral microvasculature.
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Circulating tumour DNA — looking beyond the blood
Nature Reviews Clinical Oncology, 2022Ann Tivey, Matt Church, Natalie Cook
exaly
The blood–tumour barrier in cancer biology and therapy
Nature Reviews Clinical Oncology, 2021Patricia S Steeg
exaly