Resuscitation After Hemorrhagic Shock in the Microcirculation: Targeting Optimal Oxygen Delivery in the Design of Artificial Blood Substitutes [PDF]
Frontiers in Medicine, 2020 Microcirculatory preservation is essential for patient recovery from hemorrhagic shock. In hemorrhagic shock, microcirculatory flow and pressure are greatly reduced, creating an oxygen debt that may eventually become irreversible.
Carlos Munoz +5 more
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Blood substitutes: Basic science, translational studies and clinical trials [PDF]
Frontiers in Medical Technology, 2022 COPYRIGHT © 2022 Jahr. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright ...
Jonathan S. Jahr
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Artificial Blood Substitutes: First Steps on the Long Route to Clinical Utility [PDF]
Clinical Medicine Insights: Blood Disorders, 2016 The 21st century is challenging for human beings. Increased population growth, population aging, generation of new infectious agents, and natural disasters are some threatening factors for the current state of blood transfusion.
Samira Moradi +2 more
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Hemoglobin-Based Blood Substitutes and the Treatment of Sickle Cell Disease: More Harm than Help? [PDF]
Biomolecules, 2017 Intense efforts have been made by both industry and academia over the last three decades to produce viable hemoglobin (Hb)-based oxygen carriers (HBOCs), also known as “blood substitutes”.
Abdu I. Alayash
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Artificial Blood: The History and Current Perspectives of Blood Substitutes. [PDF]
Discoveries (Craiova), 2020 Blood transfusions are one of the most common procedures performed in hospitalized patients. Yet, despite all of the measures taken to ensure the safety of the blood supply, there are known risks associated with transfusions, including infectious and ...
Khan F, Singh K, Friedman MT.
europepmc +2 more sources
Direct comparison of oligochaete erythrocruorins as potential blood substitutes. [PDF]
Bioeng Transl Med, 2017 While many blood substitutes are based on mammalian hemoglobins (e.g., human hemoglobin, HbA), the naturally extracellular hemoglobins of invertebrates (a.k.a. erythrocruorins, Ecs) are intriguing alternative oxygen carriers.
Zimmerman D +4 more
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Engineering Synthetic Erythrocytes as Next-Generation Blood Substitutes. [PDF]
Adv Funct MaterBlood scarcity is one of the main causes of healthcare disruptions worldwide, with blood shortages occurring at an alarming rate. Over the last decades, blood substitutes have aimed at reinforcing the supply of blood, with several products (e.g ...
Gomes FL +4 more
europepmc +2 more sources
Replacing the Transfusion of 1–2 Units of Blood with Plasma Expanders that Increase Oxygen Delivery Capacity: Evidence from Experimental Studies [PDF]
Journal of Functional Biomaterials, 2014 At least a third of the blood supply in the world is used to transfuse 1–2 units of packed red blood cells for each intervention and most clinical trials of blood substitutes have been carried out at this level of oxygen carrying capacity (OCC ...
Amy G. Tsai +7 more
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Artificial Cells, Nanomedicine, and Biotechnology, 2019 It is only in the last 20 years that many of the original ideas on artificial cells are being increasingly applied and extended by researchers around the world.
Thomas Ming Swi Chang
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How Nitric Oxide Hindered the Search for Hemoglobin-Based Oxygen Carriers as Human Blood Substitutes. [PDF]
Int J Mol Sci, 2023 Samaja M, Malavalli A, Vandegriff KD.
europepmc +3 more sources