Results 31 to 40 of about 98,102 (238)

Evaluation of the Stress Effect on Expression of BEST-5 Gene in Gultured Rat Hepatocytes and Cloning of This Gene [PDF]

Journal of Kerman University of Medical Sciences, 2006
Introduction:Liver has important roles in body metabolic regulation and for this reason hepatocytes are used worldwide.Investigations showed that isolation of hepatocytes causes activation of stress related genes.The aim of this study was to study the ...
GH.H Hasanshahi, A Jafarzadeh, H Hakimi, M Rezaeian, R Vaziri nejhad, S.Z Tabatabaei, A Esmaeili, E Dikson   +7 more
doaj  

Identification and functional analysis of novel phosphorylation sites in the RNA surveillance protein Upf1. [PDF]

, 2013
One third of inherited genetic diseases are caused by mRNAs harboring premature termination codons as a result of nonsense mutations. These aberrant mRNAs are degraded by the Nonsense-Mediated mRNA Decay (NMD) pathway.
Bracho, Dina P, Cajigas, Iván J, Correa, María E, Estrella, Luis A, González, Carlos I, González-Feliciano, José A, Lasalde, Clarivel, León, Alfredo J, Rivera, Andrea V, Rodríguez-Cruz, Eva N, Vega, Irving E, Wilkinson, Miles F   +11 more
core   +1 more source

Cell type-specific over-expression of chromosome 21 genes in fibroblasts and fetal hearts with trisomy 21

BMC Medical Genetics, 2006
Background Down syndrome (DS) is caused by trisomy 21 (+21), but the aberrations in gene expression resulting from this chromosomal aneuploidy are not yet completely understood.
Zigman Warren B, Silverman Wayne, Schupf Nicole, Salas Martha, Guo Meirong, Li Chi-Ming, Husain Sameera, Warburton Dorothy, Thaker Harshwardhan, Tycko Benjamin   +9 more
doaj   +1 more source

C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins [PDF]

, 2014
An expanded GGGGCC repeat in C9orf72 is the most common genetic cause of frontotemporal dementia and amyotrophic lateral sclerosis. A fundamental question is whether toxicity is driven by the repeat RNA itself and/or by dipeptide repeat proteins ...
Cabecinha, M, Clayton, EL, Cleverley, K, Devoy, A, Dols, J, Fisher, EMC, Fratta, P, Grönke, S, Hendrich, O, Isaacs, AM, Mizielinska, S, Moens, T, Niccoli, T, Nicoll, AJ, Norona, FE, Partridge, L, Pickering-Brown, S, Pietrzyk, J, Ridler, CE, Woollacott, IOC   +19 more
core   +1 more source

Optimized RNA Extraction and Northern Hybridization in Streptomycetes

Biological Procedures Online, 2010
Northern blot hybridization is a useful tool for analyzing transcript patterns. To get a picture of what really occurs in vivo, it is necessary to use a protocol allowing full protection of the RNA integrity and recovery and unbiased transfer of the ...
Tagliavia Marcello, Taravella Anna, Marineo Sandra, Puglia Anna, La Farina Mario   +4 more
doaj   +3 more sources

Identification and characteristics of microRNAs from Bombyx mori

BMC Genomics, 2008
Background MicroRNAs (miRNAs) are small RNA molecules that regulate gene expression by targeting messenger RNAs (mRNAs) and causing mRNA cleavage or translation blockage. Of the 355 Arthropod miRNAs that have been identified, only 21 are B.
Gao Xiaolian, Zhou Songping, Sheng Qing, Lv Zhengbing, Chen Jian, Chen Jianqing, Nie Zuoming, He Ping-an, Kong Lingyin, Wu Xiangfu, Jin Yongfeng, Zhang Yaozhou   +11 more
doaj   +1 more source

Polysome Profiling Analysis

Bio-Protocol, 2013
Polysome profiling is a method that allows monitoring of translation activity of mRNAs in cells and tissues. Once each polysome fractions are collected, the translation activity of each mRNA is analyzed using various molecular biology techniques such as ...
Masahiro Morita, Tommy Alain, Ivan Topisirovic, Nahum Sonenberg   +3 more
doaj   +1 more source

Identification of Five Putative Yeast RNA Helicase Genes [PDF]

, 1990
The RNA helicase gene family encodes a group of eight homologous proteins that share regions of sequence similarity. This group of evolutionarily conserved proteins presumably all utilize ATP (or some other nucleoside triphosphate) as an energy source ...
Abelson, John, Arenas, Jaime, Chang, Tien-Hsien   +2 more
core   +1 more source

Global discovery and characterization of small non-coding RNAs in marine microalgae [PDF]

, 2014
Background Marine phytoplankton are responsible for 50% of the CO2 that is fixed annually worldwide and contribute massively to other biogeochemical cycles in the oceans. Diatoms and coccolithophores play a significant role as the base of the marine food
Beckers, Matthew, Dalmay, Tamas, Lopez-gomollon, Sara, Maumus, Florian, Mock, Thomas, Mohorianu, Irina, Moulton, Vincent, Moxon, Simon, Rathjen, Tina   +8 more
core   +5 more sources

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source