Specification of BMP Signaling
Cells, 2019 Bone Morphogenetic Proteins (BMPs) together with the Growth and Differentiation Factors (GDFs) form the largest subgroup of the Transforming Growth Factor (TGF)β family and represent secreted growth factors, which play an essential role in many aspects of cell communication in higher organisms.
Joachim Nickel, Thomas D. Mueller
openaire +2 more sources
Cell ResearchTransforming growth factor-βs (TGF-βs) and bone morphometric proteins (BMPs) belong to the TGF-β superfamily and perform essential functions during osteoblast and chondrocyte lineage commitment and differentiation, skeletal development, and homeostasis ...
Mengrui Wu +3 more
semanticscholar +1 more source
Bone Morphogenetic Protein (BMP) signaling in development and human diseases
Genes and Diseases, 2014 Bone Morphogenetic Proteins (BMPs) are a group of signaling molecules that belongs to the Transforming Growth Factor-β (TGF-β) superfamily of proteins.
Richard N. Wang +19 more
semanticscholar +1 more source
BMP2 and TGF-β Cooperate Differently during Synovial-Derived Stem-Cell Chondrogenesis in a Dexamethasone-Dependent Manner [PDF]
, 2019 Recent studies highlighting mesenchymal stem cell (MSC) epigenetic memory suggest that a different differentiation medium may be required depending on the tissue of origin.
Alini, Mauro +7 more
core +1 more source
BMP-9 interferes with liver regeneration and promotes liver fibrosis
Gut, 2017 Objective Bone morphogenetic protein (BMP)-9, a member of the transforming growth factor-β family of cytokines, is constitutively produced in the liver.
K. Breitkopf-Heinlein +29 more
semanticscholar +1 more source
Sequential BMP‐2/BMP‐7 delivery from polyester nanocapsules
Journal of Biomedical Materials Research Part A, 2009 AbstractThe aim of this study was to develop a nanosized, controlled growth factor release system to incorporate into tissue engineering scaffolds and thus activate the cells seeded in the scaffold. Nanocapsules of poly(lactic acid‐co‐glycolic acid) (PLGA) and poly(3‐hydroxybutyrate‐co‐3‐hydroxyvalerate) (PHBV) were loaded with the bone morphogenetic ...
Yilgor, P., Hasirci, N., Hasirci, V.
openaire +3 more sources
Chronic myeloid leukemia cells require the bone morphogenic protein pathway for cell cycle progression and self-renewal [PDF]
, 2018 Leukaemic stem cell (LSC) persistence remains a major obstacle to curing chronic myeloid leukaemia (CML). The bone morphogenic protein (BMP) pathway is deregulated in CML, with altered expression and response to the BMP ligands shown to impact on LSC ...
Busch, Caroline +6 more
core +2 more sources
TGF-β/BMP signaling and other molecular events: regulation of osteoblastogenesis and bone formation
Bone Research, 2015 Transforming growth factor-beta (TGF-β)/bone morphogenetic protein (BMP) plays a fundamental role in the regulation of bone organogenesis through the activation of receptor serine/threonine kinases.
M. S. Rahman +4 more
semanticscholar +1 more source
Differential involvement of Wnt signaling in Bmp regulation of cancellous versus periosteal bone growth [PDF]
, 2017 Bone morphogenetic proteins (Bmp) are well-known to induce bone formation following chondrogenesis, but the direct role of Bmp signaling in the osteoblast lineage is not completely understood.
Bellido, Teresita +5 more
core +3 more sources
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source