Results 161 to 170 of about 114,435 (209)

TheC. elegansLON-1 protein requires its CAP domain for function in regulating body size and BMP signaling

Serrano MV, Cottier S, Wang L, Moreira-Antepara S, Nzessi A, Liu Z, Williams B, Lee M, Schneiter R, Liu J.   +9 more
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BMP Signaling and Skeletogenesis

Annals of the New York Academy of Sciences, 2006
Abstract:  Bone morphogenetic proteins (BMPs) are members of the transforming growth factor (TGF)‐β superfamily of signal molecules that mediate many diverse biological processes ranging from early embryonic tissue patterning to postnatal tissue homeostasis. BMPs trigger cell responses mainly through the canonical signaling pathway where intracellular
Xuelin, Li, Xu, Cao
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BMP signaling controls muscle mass

Nature Genetics, 2013
Cell size is determined by the balance between protein synthesis and degradation. This equilibrium is affected by hormones, nutrients, energy levels, mechanical stress and cytokines. Mutations that inactivate myostatin lead to excessive muscle growth in animals and humans, but the signals and pathways responsible for this hypertrophy remain largely ...
Sartori R, Schirwis E, BLAAUW, BERT, Bortolanza S, Zhao J, ENZO, ELENA, Stantzou A, Mouisel E, TONIOLO, LUANA, Ferry A, Stricker S, Goldberg AL, DUPONT, SIRIO, PICCOLO, STEFANO, Amthor H, SANDRI, MARCO   +15 more
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BMP signaling in skeletal development

Biochemical and Biophysical Research Communications, 2005
Development of the vertebrate skeleton, a complex biological event that includes diverse processes such as formation of mesenchymal condensations at the sites of future skeletal elements, osteoblast and chondrocyte differentiation, and three dimensional patterning, is regulated by many growth factors.
Mei, Wan, Xu, Cao
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BMP signalling in early Xenopus development

BioEssays, 1999
Bone morphogenetic proteins (BMPs) are typically members of the transforming growth factor beta (TGF-beta) family with diverse roles in embryonic development. At least five genes with homology to BMPs are expressed during Xenopus development, along with their receptors and intracellular signalling pathways. The evidence suggests that BMPs have roles to
L, Dale, C M, Jones
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Bmp signaling in molar cusp formation

Gene Expression Patterns, 2019
Tooth cusp is a crucial structure, since the shape of the molar tooth is determined by number, shape, and size of the cusp. Bone morphogenetic protein (Bmp) signaling is known to play a critical role in tooth development, including in initiation. However, it remains unclear whether Bmp signaling is also involved in cusp formation.
Fumiya, Meguro, Thantrira, Porntaveetus, Maiko, Kawasaki, Katsushige, Kawasaki, Akane, Yamada, Yoshito, Kakihara, Makio, Saeki, Koichi, Tabeta, John A, Kessler, Takeyasu, Maeda, Atsushi, Ohazama   +10 more
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BRAM1, a BMP receptor‐associated molecule involved in BMP signalling

Genes to Cells, 1998
BackgroundTGF‐β superfamily members elicit signals through the stimulation of serine/threonine‐kinase receptors. Recently, molecules associated with several TGF‐β family receptors have been cloned. One such molecule, the immunophilin FKBP12, has been reported to interact with TGF‐β family type I receptors.
K, Kurozumi, M, Nishita, K, Yamaguchi, T, Fujita, N, Ueno, H, Shibuya   +5 more
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Making sense of BMP signaling complexity

Cell Systems, 2022
Cellular signaling systems are immensely complex. Dedicated experimental and theoretical approaches are therefore required to decipher how they function. In this issue of Cell Systems, two studies systematically interrogate the Bone Morphogenetic Protein (BMP) pathway, uncovering mechanisms and consequences of distinct responses to combinations of BMP ...
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BMP signalling specifies the pyloric sphincter

Nature, 1999
Sphincters are muscular valves that form at the boundaries between organs of the gut; for example, the pyloric sphincter forms at the junction of the small intestine and stomach. We show here that signalling by bone morphogenetic protein (BMP) from the avian small intestine induces the cells of the adjacent gizzard (the equivalent of the stomach in the
D M, Smith, C J, Tabin
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Recent advances in BMP receptor signaling

Cytokine & Growth Factor Reviews, 2009
Bone Morphogenetic Proteins (BMPs) play an important role during organ development and during regeneration after tissue damage. BMPs signal via transmembrane serine/threonine kinase receptors. From our current understanding heteromeric complexes of type I and type II receptors are required for signal propagation.
Christina, Sieber, Jessica, Kopf, Christian, Hiepen, Petra, Knaus   +3 more
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