Results 81 to 90 of about 2,812 (182)

RPA Combined With CRISPR/Cas12a for Rapid and Ultrasensitive Detection Dual‐Gene of Methicillin‐Resistant Staphylococcus aureus (MRSA)

Journal of Molecular Recognition, Volume 39, Issue 3, May 2026.
ABSTRACT The increasing issue of infections caused by methicillin‐resistant Staphylococcus aureus (MRSA) necessitates rapid and reliable diagnostic methods. While existing RPA‐CRISPR/Cas12a platforms have demonstrated potential for MRSA detection, most rely on single‐gene targets or require multiple Cas enzymes.
Lei Chen, Jun Luo, Helin Zhang, Pingsen Zhao   +3 more
wiley   +1 more source

Gut Microbiota‐Derived Anandamide Mediates the Therapeutic Effects of Urolithin A on Alcohol‐Induced Cognitive and Social Dysfunction via CB1R‐DRD2‐RAP1 Signaling Axis

Advanced Science, Volume 13, Issue 20, 9 April 2026.
This study reveals that Urolithin A (UA) counteracts alcohol‐induced cognitive and social dysfunction (AICSD) via a gut microbiome‐dependent mechanism. UA‐enriched Bacteroids sartorii and Parabacteroids distasonis elevate anandamide (AEA), which activates the CB1R‐DRD2‐Rap1 signaling cascade to drive synaptic repair and reduce neuroinflammation ...
Hongbo Zhang, Zibin Li, Yao Xiao, Ji Bian, Caian He, Chao Liu, Lan Gong, Lin Han, Zhigang Liu, Min Wang   +9 more
wiley   +1 more source

An analysis of the students performance and the content covered in the items of Genetics and Evolutionary Biology of the National High School Exam (ENEM): curricular implications

Investigações em Ensino de Ciências, 2020
In the last decades, Genetics and Evolutionary Biology have become promising and intriguing areas. However, although their concepts are considered important in the formation of critical and socially responsible citizens, Brazilian teachers and students ...
Débora Cristina Cestaro, Maurício Urban Kleinke, Lupe Furtado Alle   +2 more
doaj   +1 more source

Extracellular Vesicles of Streptococcus anginosus Mediate Gastritis via Epithelial Barrier Disruption and Macrophage‐driven Inflammation

Advanced Science, Volume 13, Issue 19, 2 April 2026.
Streptococcus anginosus extracellular vesicles (SA‐EVs) accumulate in gastric tissue, disrupt epithelial tight junctions, and induce gastritis characterized by neutrophil infiltration and elevated cytokines (TNF‐α, IL‐6, IL‐17A). Proteomics identifies TMPC and FBP62 as key SA‐EVs virulence factors; their genetic deletion attenuates inflammation ...
Ying Gong, Lina Duan, Jie Xiao, Yulu Deng, Hongxia Wang, Yajie Zhang, Xiumei Hu, Haifang Wang, Taixue An, Xin Li, Yurong Qiu, Lei Zheng, Haixia Li   +12 more
wiley   +1 more source

A INTERFERÊNCIA DA PEDAGOGIA DOS MULTILETRAMENTOS NA BNCC DE LÍNGUA PORTUGUESA DO ENSINO FUNDAMENTAL

Linguagens, Educação e Sociedade
Neste trabalho, nos propomos a analisar a Base Nacional Comum Curricular (BNCC) de Língua Portuguesa dos Anos Finais do Ensino Fundamental, com foco na proposta dos multiletramentos. Trata-se de um recorte de uma pesquisa de mestrado em andamento. Por se
Rogéria Dantas de Melo Justino, Roziane Marinho Ribeiro   +1 more
doaj   +1 more source

Argumentação e Prova em Matemática: uma análise dos itens públicos do PISA 2012

Revista Baiana de Educação Matemática, 2020
Neste artigo, o objetivo é analisar os itens públicos do Programa Internacional de Avaliação dos Estudantes (PISA, em inglês) de 2012 que versem sobre argumentação e prova em Matemática.
João Caldato , Carlos Augusto Aguilar Júnior   +1 more
doaj   +1 more source

Vivências de professoras dos Anos Iniciais no trabalho com a resolução de problemas em uma formação continuada

Educação Matemática Debate, 2021
Este artigo tem como objetivo investigar as vivências de professoras dos Anos Iniciais do Ensino Fundamental no trabalho com a resolução de problemas a partir da unidade temática Números da Base Nacional Comum Curricular (BNCC) e na oficina Brincando ...
Sandra Alves de Oliveira, Dayselane Pimenta Lopes Rezende, Andreia Rezende Garcia Reis, Reginaldo Fernando Carneiro   +3 more
doaj   +1 more source

A Glucose‐Responsive Intelligent Antibacterial and Oxygen‐Producing Hydrogel Promotes the Healing of Diabetic Wounds by Regulating Cellular Heterogeneity

Advanced Science, Volume 13, Issue 19, 2 April 2026.
We have developed a glucose‐triggered on‐demand drug delivery CF‐CPGaMPN hydrogel based on borate ester bonds. It inactivates microbes, releases oxygen, and enables on‐demand drug release in high‐glucose environments to promote healing of diabetic wounds. Single‐cell sequencing reveals that the CF‐CPGaMPN hydrogel significantly alleviates dysfunctional
Manxuan Liu, Zhongcheng Li, Qian Ren, Ziqian Lu, Yubing Zhang, Yili Guo, Ruomeng Li, Die Hu, Linglin Zhang   +8 more
wiley   +1 more source

BNCC na Prática Pedagógica

Brazilian Journal of Business
A Base Nacional Comum Curricular (BNCC) é um documento que estabelece os direitos de aprendizagem e desenvolvimento para os estudantes brasileiros. Este artigo tem como objetivo analisar a BNCC na prática pedagógica, esclarecendo suas principais mudanças e orientações para a implementação no Ensino Fundamental e Educação Infantil.
Andressa Alves Semensati, Mariley Schafer, Geovana Andressa de Oliveira Silva Stivanelli, Maria Alessandra de Oliveira Baptista, Caroline Santana Allegretti, Narcisa Ferreira Fuzzi de Carvalho, Cleide Rodrigues dos Santos Ros, Angelita Francisca da Silva, Eliane Aparecida Bento   +8 more
openaire   +1 more source

Aberrant Splicing Signatures Underpin Oligodendrocyte Damage in ALS and Neuron Loss in FTD

Advanced Science, Volume 13, Issue 17, 23 March 2026.
Integrating bulk and single‐nucleus RNA‐seq from ALS and FTD patients, we revealed distinct cellular dysfunctions, with severe oligodendrocyte damage in ALS and pronounced neuron loss in FTD. We identified cell‐type‐specific aberrant splicing events as potential biomarkers with robust classification performance, some of which produce de novo peptides ...
Chen Du, Yinming Li, Rong Wu, Yufei Shen, Jiayi Yang, Xuan Xiao, Yu Zhou   +6 more
wiley   +1 more source