Results 1 to 10 of about 2,067 (154)

Clinical application of boron neutron capture therapy for cancer treatment: A systematic review [PDF]

Precision Radiation Oncology
Boron neutron capture therapy (BNCT) combines boron drug delivery and heavy‐ion therapy. The key factors in the application of BNCT are high‐quality neutron beams and boron‐containing compounds.
Ling Zhou, Yuming Chen, Meng Peng, Xiumao Yin, Huanqing Liang, Jieming Mo, Wan Zhang, Zhigang Liu   +7 more
doaj   +3 more sources

Clinical outcomes of boron neutron capture therapy for unresectable oral cancer: a retrospective analysis [PDF]

Frontiers in Oncology
BackgroundSurgery is the standard treatment for oral cancer but often causes functional and cosmetic problems, and reoperation is difficult. Radiotherapy (RT) is less effective, with reirradiation limited by normal tissue tolerance and salvage surgery ...
Yuki Yoshino, Yuki Yoshino, Yuki Yoshino, Satoshi Takeno, Satoshi Takeno, Teruhito Aihara, Teruhito Aihara, Naonori Hu, Naonori Hu, Akinori Sasaki, Kazuhiko Akita, Yasukazu Kanai, Yasukazu Kanai, Mai Nojiri, Tsuyoshi Jinnin, Tetsuya Terada, Shinichi Haginomori, Keiji Nihei, Keiji Nihei, Koji Ono, Koji Ono   +20 more
doaj   +2 more sources

Advances in Clinical Trials of Boron Neutron Capture Therapy [PDF]

Research
Boron neutron capture therapy (BNCT) is a targeted radiotherapy technique that enables dual targeting at the physico-biological level. Efficient neutron sources and specific boron carriers are essential for successful treatment. By exploiting the 10B(n,α)
Xiaoling Li, Zhijie Liu, Kejun Liu, Chunhong Wang, Zhigang Liu, Xiao Xu   +5 more
doaj   +2 more sources

Boron neutron capture therapy preserves immune cells and induces robust anti-tumour immunity in preclinical mouse model [PDF]

Nature Communications
Radiotherapy can both activate and suppress immunity, making it difficult to predict or modulate these opposing effects for better cancer treatment.
Qi Sun, Yanping Zhao, Simiao Qiao, Kexuan Wang, Chuanjie Lu, Zizhu Zhang, Zhibin Guo, Zexuan Ding, Chunhong Wang, Jiyuan Li, Tong Liu, Zexian Zeng, Zhibo Liu   +12 more
doaj   +2 more sources

Boron neutron capture therapy for melanoma: recent advances and future prospects [PDF]

Frontiers in Oncology
Boron neutron capture therapy (BNCT) is a unique radiotherapy modality that targets and destroys selectively tumor cells that have absorbed boron, while leaving surrounding healthy cells unharmed.
Yuanyang Sun, Yun Wang, Shukun Mu, Xiaofeng Wu, Suchun Yu, Zhongming Wang   +5 more
doaj   +2 more sources

Mechanotransduction-related ferroptosis: Enhancing boron neutron capture therapy efficacy in glioblastoma using a spheroid model [PDF]

Molecular Therapy: Oncology
Boron neutron capture therapy (BNCT) shows potential for the treatment of glioblastoma, the most aggressive form of primary brain tumor. Recently, ferroptosis, a cell death triggered by phospholipid peroxidation, has been identified as an important ...
Lin-Sheng Yu, Jia-Jun Liu, Ming-Hung Yang, Yu-chun Lin, Chi-Shuo Chen   +4 more
doaj   +2 more sources

Development and evaluation of surface-guided patient position system for boron neutron capture therapy [PDF]

Scientific Reports
Boron Neutron Capture Therapy (BNCT) is an advanced form of radiotherapy that uses the neutron capture reaction of boron-10 to selectively destroy cancer cells.
Jiang Chen, Qiao-Lin Xie, Jing-Jing Ping, Ting-Ting Hou, Yuan-Hao Liu   +4 more
doaj   +2 more sources

Manganese-enriched nanoboron agent amplifies BNCT efficacy via pyroptosis-mediated immune activation and STING pathway synergy​ [PDF]

Journal of Nanobiotechnology
Boron Neutron Capture Therapy (BNCT) offers selective tumor cell ablation with minimal damage to normal tissues, but its efficacy is limited by therapy-induced immunosuppression and high intratumoral H2O2 levels, restricting synergy with immunotherapy ...
Zhicheng Zhang, Xiaoyan Sun, Yaxin Qin, Yufan Yang, Qi Dai, Xiaoyan Bao, Minoru Suzuki, Sheng Wang, Zai Yang, Zhifeng Li, Min Han, Donghang Xu, Qichun Wei   +12 more
doaj   +2 more sources

The Anti-Tumor Effect of Boron Neutron Capture Therapy in Glioblastoma Subcutaneous Xenograft Model Using the Proton Linear Accelerator-Based BNCT System in Korea

Life, 2022
Boron neutron capture therapy (BNCT) is a radiation therapy that selectively kills cancer cells and is being actively researched and developed around the world.
Il Hyeok Seo, Jeongwoo Lee, Dasom Na, Hyunhye Kyung, Jieun Yang, Sangbong Lee, Sang June Jeon, Jae Won Choi, Kyu Young Lee, Jungyu Yi, Jaehwan Han, Mooyoung Yoo, Se Hyun Kim   +12 more
doaj   +1 more source

Therapeutic Efficacy, Radiotoxicity and Abscopal Effect of BNCT at the RA-3 Nuclear Reactor Employing Oligo-Fucoidan and Glutamine as Adjuvants in an Ectopic Colon Cancer Model in Rats

Life, 2023
Boron neutron capture therapy (BNCT) is based on the preferential uptake of 10B compounds by tumors, followed by neutron irradiation. The aim of this study was to assess, in an ectopic colon cancer model, the therapeutic efficacy, radiotoxicity, abscopal
Debora N. Frydryk Benitez, Mónica A. Palmieri, Yanina V. Langle, Andrea Monti Hughes, Emiliano C. C. Pozzi, Silvia I. Thorp, Marcela A. Garabalino, Paula Curotto, Paula S. Ramos, María L. Paparella, Lucas Polti, Ana Eiján, Amanda E. Schwint, Verónica A. Trivillin   +13 more
doaj   +1 more source