Results 11 to 20 of about 2,067 (154)

Development and dosimetric evaluation of a freely deformable ⁶Li-based neutron shield for boron neutron capture therapy. [PDF]

Med Phys
Abstract Background Boron neutron capture therapy (BNCT) enables selective tumor irradiation by exploiting the high‐linear energy transfer particles generated from neutron interactions with 10B atoms. BNCT has been approved as an insurance‐covered medical treatment for recurrent head and neck cancer in Japan.
Hu N, Kakino R, Sasaki A, Nojiri M, Akita K, Yoshikawa S, Kohigashi Y, Yoshino Y, Takeno S, Aihara T, Takata T, Tanaka H, Nihei K, Ono K.   +13 more
europepmc   +2 more sources

Evaluation of a treatment planning system developed for clinical boron neutron capture therapy and validation against an independent Monte Carlo dose calculation system

Radiation Oncology, 2021
Boron neutron capture therapy (BNCT) for the treatment of unresectable, locally advanced, and recurrent carcinoma of the head and neck cancer has been approved by the Japanese government for reimbursement under the national health insurance as of June ...
Naonori Hu, Hiroki Tanaka, Ryo Kakino, Syuushi Yoshikawa, Mamoru Miyao, Kazuhiko Akita, Kayako Isohashi, Teruhito Aihara, Keiji Nihei, Koji Ono   +9 more
doaj   +1 more source

Improvement in the neutron beam collimation for application in boron neutron capture therapy of the head and neck region

Scientific Reports, 2022
In June 2020, the Japanese government approved boron neutron capture therapy for the treatment of head and neck cancer. The treatment is usually performed in a single fraction, with the neutron irradiation time being approximately 30–60 min.
Naonori Hu, Hiroki Tanaka, Ryo Kakino, Syuushi Yoshikawa, Mamoru Miyao, Kazuhiko Akita, Teruhito Aihara, Keiji Nihei, Koji Ono   +8 more
doaj   +1 more source

Enhancement of dose distribution using tissue compensators in boron neutron capture therapy. [PDF]

J Appl Clin Med Phys
Abstract In BNCT for head and neck tumors delivered with a horizontal beam, the presence of missing tissue near the beam path can cause reduction in neutron fluence rate in adjacent tissue regions due to the loss of scattered neutrons. These regions are referred to as neutron depleted areas.
Sasaki A, Hu N, Nojiri M, Akita K, Yoshikawa S, Kohigashi Y, Nihei K, Aihara T, Takeno S, Yoshino Y, Tanaka H, Ono K.   +11 more
europepmc   +2 more sources

Exploration of the threshold SUV for diagnosis of malignancy using 18F-FBPA PET/CT

European Journal of Hybrid Imaging, 2022
Background The goal of the study was to evaluate the diagnostic ability of 18F-FBPA PET/CT for malignant tumors. Findings from 18F-FBPA and 18F-FDG PET/CT were compared with pathological diagnoses in patients with malignant tumors or benign lesions ...
Kayako Isohashi, Yasukazu Kanai, Teruhito Aihara, Naonori Hu, Kentaro Fukushima, Ichiro Baba, Fumitoshi Hirokawa, Ryo Kakino, Tsuyoshi Komori, Keiji Nihei, Jun Hatazawa, Koji Ono   +11 more
doaj   +1 more source

Next-Generation Boron Drugs and Rational Translational Studies Driving the Revival of BNCT

Cells, 2023
BNCT is a high-linear-energy transfer therapy that facilitates tumor-directed radiation delivery while largely sparing adjacent normal tissues through the biological targeting of boron compounds to tumor cells.
Danushka S. Seneviratne, Omran Saifi, Yuri Mackeyev, Timothy Malouff, Sunil Krishnan   +4 more
doaj   +1 more source

Accelerator-based BNCT [PDF]

Applied Radiation and Isotopes, 2014
The activity in accelerator development for accelerator-based BNCT (AB-BNCT) both worldwide and in Argentina is described. Projects in Russia, UK, Italy, Japan, Israel, and Argentina to develop AB-BNCT around different types of accelerators are briefly presented.
Kreiner, Andres Juan, Baldo, Monica Iris, Bergueiro, Rodolfo Javier, Cartelli, Daniel Enrique, Castell, W., Thatar Vento, Vladimir, Gomez Asoia, J., Mercuri, D., Padulo, J., Suarez Sandin, J. C., Erhardt, J., Kesque, J. M., Valda, A. A., Debray, Mario Ernesto, Somacal, Héctor Rubén, Igarzabal, M., Minsky, Daniel Mauricio, Herrera, Maria Silvia, Capoulat, Maria Eugenia, González, Sara Josefina, del Grosso, Mariela Fernanda, Gagetti, Leonardo, Suárez Anzorena; M., Gun, M., Carranza, O.   +24 more
openaire   +3 more sources

Dose-Dependent Suppression of Human Glioblastoma Xenograft Growth by Accelerator-Based Boron Neutron Capture Therapy with Simultaneous Use of Two Boron-Containing Compounds

Biology, 2021
(1) Background: Developments in accelerator-based neutron sources moved boron neutron capture therapy (BNCT) to the next phase, where new neutron radiation parameters had to be studied for the treatment of cancers, including brain tumors.
Vladimir Kanygin, Ivan Razumov, Alexander Zaboronok, Evgenii Zavjalov, Aleksandr Kichigin, Olga Solovieva, Alphiya Tsygankova, Tatiana Guselnikova, Dmitrii Kasatov, Tatiana Sycheva, Bryan J. Mathis, Sergey Taskaev   +11 more
doaj   +1 more source

NeuTHOR Station—A Novel Integrated Platform for Monitoring BNCT Clinical Treatment, Animal and Cell Irradiation Study at THOR

Life, 2023
(1) Background: A well-established Boron Neutron Capture Therapy (BNCT) facility includes many essential systems, which are the epithermal neutron beam system, on-line monitoring system (OMS), QA/QC (quality assurance or quality control) system, boron ...
Yu-Shiang Huang, Jinn-Jer Peir, Chuan-Jen Wu, Mei-Ya Wang, Yi-Wei Chen, Jia-Cheng Lee, Fong-In Chou   +6 more
doaj   +1 more source

Enhancement in the Therapeutic Efficacy of In Vivo BNCT Mediated by GB-10 with Electroporation in a Model of Oral Cancer

Cells, 2023
Boron neutron capture therapy (BNCT) combines preferential tumor uptake of 10B compounds and neutron irradiation. Electroporation induces an increase in the permeability of the cell membrane.
Nahuel Olaiz, Andrea Monti Hughes, Emiliano C. C. Pozzi, Silvia Thorp, Paula Curotto, Verónica A. Trivillin, Paula S. Ramos, Mónica A. Palmieri, Guillermo Marshall, Amanda E. Schwint, Marcela A. Garabalino   +10 more
doaj   +1 more source