Results 21 to 30 of about 2,067 (154)

Response of Normal Tissues to Boron Neutron Capture Therapy (BNCT) with ¹⁰B-Borocaptate Sodium (BSH) and ¹⁰B-Paraboronophenylalanine (BPA)

Cells, 2021
Boron neutron capture therapy (BNCT) is a cancer-selective radiotherapy that utilizes the cancer targeting 10B-compound. Cancer cells that take up the compound are substantially damaged by the high liner energy transfer (LET) particles emitted mainly ...
Hiroshi Fukuda
doaj   +1 more source

Clinical Veterinary Boron Neutron Capture Therapy (BNCT) Studies in Dogs with Head and Neck Cancer: Bridging the Gap between Translational and Clinical Studies

Biology, 2020
Translational Boron Neutron Capture Therapy (BNCT) studies performed by our group and clinical BNCT studies worldwide have shown the therapeutic efficacy of BNCT for head and neck cancer. The present BNCT studies in veterinary patients with head and neck
Amanda E. Schwint, Andrea Monti Hughes, Marcela A. Garabalino, Gustavo A. Santa Cruz, Sara J. González, Juan Longhino, Lucas Provenzano, Paulina Oña, Monica Rao, María de los Ángeles Cantarelli, Andrea Leiras, María Silvina Olivera, Verónica A. Trivillin, Paula Alessandrini, Fabricio Brollo, Esteban Boggio, Hernan Costa, Romina Ventimiglia, Sergio Binia, Emiliano C. C. Pozzi, Susana I. Nievas, Iara S. Santa Cruz   +21 more
doaj   +1 more source

5-Aminolevulinic acid increases boronophenylalanine uptake into glioma stem cells and may sensitize malignant glioma to boron neutron capture therapy

Scientific Reports, 2023
Boron neutron capture therapy (BNCT) is a high-LET particle radiotherapy clinically tested for treating malignant gliomas. Boronophenylalanine (BPA), a boron-containing phenylalanine derivative, is selectively transported into tumor cells by amino acid ...
Masao Fukumura, Naosuke Nonoguchi, Shinji Kawabata, Ryo Hiramatsu, Gen Futamura, Koji Takeuchi, Takuya Kanemitsu, Takushi Takata, Hiroki Tanaka, Minoru Suzuki, Oltea Sampetrean, Naokado Ikeda, Toshihiko Kuroiwa, Hideyuki Saya, Ichiro Nakano, Masahiko Wanibuchi   +15 more
doaj   +1 more source

Carborane Polypeptide Derivatives for Boron Neutron Capture Therapy

He huaxue yu fangshe huaxue, 2023
The design and application of carborane polypeptide derivatives have attracted more and more attention, especially as boron carrier in the treatment of malignant tumors(BNCT).
HAN Yi, LI Feng-lin, LUO Zhi-fu
doaj   +1 more source

Investigation on the efficacy of a tissue equivalent material bolus for BNCT. [PDF]

J Appl Clin Med Phys
Abstract Background In radiation therapy, the use of bolus is an effective technique for improving the surface dose. This irradiation technique is also used in BNCT. However, since BNCT uses neutron irradiation, it is important to evaluate both the neutron moderation characteristic and the radioactivation of the bolus.
Sasaki A, Hu N, Kakino R, Nojiri M, Nihei K, Aihara T, Takeno S, Yoshino Y, Tanaka H, Ono K.   +9 more
europepmc   +2 more sources

Experimental terminal design of BNCT neutron source based on 14 MeV proton cyclotron

He jishu, 2022
BackgroundWith the development of accelerator technology, the accelerator-based Boron Neutron Capture Therapy (BNCT) has attracted more and more attention, and metallic 9Be is one of the most suitable materials for neutron-producing targets.PurposeThe ...
LU Yu, LI Wenyi, XU Zhao, LI Taosheng
doaj   +1 more source

Application and Development of Tumor-Targeting Boron Carriers in Boron Neutron Capture Therapy

He huaxue yu fangshe huaxue, 2023
Boron neutron capture therapy(BNCT) is a promising therapeutic method for malignant tumors and has entered the clinical trials. As a binary cellular accurate therapy, BNCT relies on tumor-targeting boron delivery.
CHEN Kui, LYU Lin-wen, XING Geng-mei
doaj   +1 more source

Advances in boron neutron capture therapy (BNCT) at kyoto university - From reactor-based BNCT to accelerator-based BNCT [PDF]

Journal of the Korean Physical Society, 2015
At the Kyoto University Research Reactor Institute (KURRI), a clinical study of boron neutron capture therapy (BNCT) using a neutron irradiation facility installed at the research nuclear reactor has been regularly performed since February 1990. As of November 2014, 510 clinical irradiations were carried out using the reactor-based system.
Sakurai, Yoshinori, Tanaka, Hiroki, Takata, Takushi, Fujimoto, Nozomi, Suzuki, Minoru, Masunaga, Shinichiro, Kinashi, Yuko, Kondo, Natsuko, Narabayashi, Masaru, Nakagawa, Yosuke, Watanabe, Tsubasa, Ono, Koji, Maruhashi, Akira   +12 more
openaire   +1 more source

A comparison of dose distributions in gross tumor volume between boron neutron capture therapy alone and combined boron neutron capture therapy plus intensity modulation radiation therapy for head and neck cancer.

PLoS ONE, 2019
Nine patients with recurrent head and neck (H&N) cancer received boron neutron capture therapy (BNCT) in one fraction at the Tsing-Hua Open pool reactor (THOR) utilizing the THORplan treatment planning system (TPS).
Jia-Cheng Lee, Keh-Shih Chuang, Yen-Wan Hsueh Liu, Tzung-Yi Lin, Yi-Chiao Teng, Ling-Wei Wang   +5 more
doaj   +1 more source

Current development status of accelerator-based neutron source for boron neutron capture therapy

EPJ Techniques and Instrumentation, 2023
Recently, progress in technology for accelerator-based neutron sources has increased attention regarding boron neutron capture therapy (BNCT). BNCT is a type of radiotherapy that combines neutrons and boron drugs and is expected to be used in the ...
Hiroaki Kumada, Takeji Sakae, Hideyuki Sakurai   +2 more
doaj   +1 more source