Results 211 to 220 of about 19,441 (231)

Structural Basis for Dimerization of the BNIP3 Transmembrane Domain^,

Biochemistry, 2009
Mutagenesis data suggest that BNIP3 transmembrane domain dimerization depends critically on hydrogen bonding between His 173 and Ser 172, but a recent structural analysis indicates that these residues adopt multiple conformations and are not always hydrogen bonded.
Endah S, Sulistijo, Kevin R, Mackenzie
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Structure, function, and epigenetic regulation of BNIP3: a pathophysiological relevance

Molecular Biology Reports, 2014
BCL-2 [B-cell leukemia/lymphoma 2]/adenovirus E1B 19KD interacting protein 3 (BNIP3) is an atypical BH3 domain only containing member of Bcl2 family of proteins. BNIP3 is known to be involved in various cellular processes depending on the cell type and conditions and also shown to play a role in various disease conditions including myocardial ischemia,
Nagarjuna, Vasagiri, Vijay Kumar, Kutala
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BNip3 is a mediator of TNF-induced necrotic cell death

Apoptosis, 2010
Tumor necrosis factor (TNF) is a pleiotropic cytokine involved in immune modulation, inflammatory reactions, and target cell death in many pathologic conditions. The cell death pathways triggered by TNF include the caspase-8/Bid-dependent apoptotic pathway and the caspase-independent necrosis pathway (necroptosis).
Jee-Youn, Kim, Yong-Jun, Kim, Sun, Lee, Jae-Hoon, Park   +3 more
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Hypoxia and expression of the proapoptotic regulator BNIP3 in cervical cancer

International Journal of Gynecological Cancer, 2006
Hypoxia plays a major role in the malignant progression of tumors. Here, we investigate the expression of Bcl-2/adenovirus E1B 19 kd-interacting protein 3 (BNIP3), a proapoptotic Bcl-2 family member, and its relationship to hypoxia in cervical cancer cell lines and clinical samples of cervical cancer. Cervical cancer cell lines were grown under hypoxia
C, Leo, L-C, Horn, M, Höckel
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Thymidine phosphorylase inhibits the expression of proapoptotic protein BNIP3

Biochemical and Biophysical Research Communications, 2008
An angiogenic factor, thymidine phosphorylase (TP), confers resistance to apoptosis induced by hypoxia. We investigated the molecular basis for the suppressive effect of TP on hypoxia-induced apoptosis using Jurkat cells transfected with TP cDNA, Jurkat/TP, and a mock transfectant, Jurkat/CV.
Ryuji, Ikeda, Yusuke, Tajitsu, Ken-Ichi, Iwashita, Xiao-Fang, Che, Kenichi, Yoshida, Mina, Ushiyama, Tatsuhiko, Furukawa, Masaharu, Komatsu, Tatsuya, Yamaguchi, Yoshihiko, Shibayama, Masatatsu, Yamamoto, Hong-Ye, Zhao, Junko, Arima, Yasuo, Takeda, Shin-Ichi, Akiyama, Katsushi, Yamada   +15 more
openaire   +2 more sources

Expression of the cell death genes BNip3 and NIX in ductal carcinoma in situ of the breast; correlation of BNip3 levels with necrosis and grade

The Journal of Pathology, 2003
Abstract Ductal carcinoma in situ (DCIS) of the breast is an early, non‐invasive lesion and the prognosis is associated with the extent of necrosis and cell death within the tumour.
Heidi Michelle, Sowter, Mary, Ferguson, Caroline, Pym, Peter, Watson, Stephen B, Fox, Cheng, Han, Adrian L, Harris   +6 more
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H-ras up-regulates expression of BNIP3.

Anticancer research, 2011
Bcl-2/adenovirus E1B 19-kDa protein-interacting protein 3 (BNIP3) is a key regulator of cell death/autophagy and can act as an effector of a necrosis-like, atypical death program. It was implicated in execution of cell death induced by cluster of differentiation 47 (CD47).
Wojciech, Kalas, Ewelina, Swiderek, Andrzej, Rapak, Magdalena, Kopij, Janusz, Rak, Leon, Strzadala   +5 more
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Functions of BNIP3 in Nutrient Stress Responses

2019
BNIP3 is a mitophagy receptor that targets mitochondria for degradation at the autophagolysosome. By mediating mitophagy, BNIP3 functions to decrease mitochondrial mass as an adaptive response to stress, namely hypoxia and nutrient starvation. This catabolic mechanism prevents the accumulation of damaging reactive oxygen species that are normally ...
openaire   +1 more source

BNIP3 promotes HIF‐1α‐driven melanoma growth by curbing intracellular iron homeostasis

EMBO Journal, 2021
Monica Vara-Perez, Vivek Venkataramani, bernhard Michalke   +2 more
exaly  

Response to myocardial ischemia/reperfusion injury involves Bnip3 and autophagy

Cell Death and Differentiation, 2006
Susan E Logue, Åsa B Gustafsson
exaly